Auditory Evoked Magnetic Fields to Tones and Pseudowords in Healthy Children and Adults

Paetau, Ritva; Ahonen, Antti; Salonen, Oili; Sams, Mikko

doi:10.1097/00004691-199503000-00008

Cited by 155 publications

(118 citation statements)

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“…Previous reports indicate that M100 latency is dependent on age, with longer latencies for younger children [3,10,11]. In order to remove age effects in the present analysis, M100 latency was normalized by dividing M100 latency for each tone by the latency of the 1000 Hz tone for each hemisphere, for each participant.…”

Section: Resultsmentioning

confidence: 99%

“…We have previously reported a dynamic range of M100 latency modulation for tones ranging from 100 to 1000 Hz of B25-30 ms in healthy adults [4,7]. Based on previous MEG investigations with children, we expect that, overall, M100 latencies will be somewhat prolonged (30-70 ms) in children compared with adults [3,10,11]. Here we evaluate whether the dynamic range of M100 latency modulation is larger in children then in adults, reflecting an overall expansion of the range commensurate with the prolonged latency found in children, or whether the absolute range is similar in children to previous reports for adults, indicating that the frequency modulation is on a similar scale to adults but shifted in time.…”

Section: Introductionmentioning

confidence: 93%

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Cortical sound processing in children with autism disorder: an MEG investigation

Gage¹,

Siegel

Callen

et al. 2003

NeuroReport

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Previous work investigating frequency encoding mechanisms in human auditory cortex has provided evidence that latency of the auditory evoked M100 is strongly proportional to frequency, with low frequency (100^200 Hz) tones associated with B30 ms longer latencies than mid-range frequency (1^2 kHz) tones. Motivated by pervasive speech and auditory perception de¢cits observed in autism spectrum disorder, we evaluated M100 frequency dependence in children with autism disorder and typically developing controls.Results indicate that for control children, the dynamic range of frequency modulation was similar to previous reports for healthy adults. Children with autism had a much reduced range of modulation in right hemisphere sites. Findings indicate that frequency encoding mechanisms may follow a di¡erential maturational path in autism spectrum disorder.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Cortical sound processing in children with autism disorder: an MEG investigation

Gage¹,

Siegel

Callen

et al. 2003

NeuroReport

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show abstract

“…Some authors argue that the child N250 is commensurate with the adult N100 (Korpilahti and Lang, 1994;Kurtzberg, Vaughan, Kreuzer, & Fliegler, 1995), while other authors think of it as a counterpart of the adult N2. Paetau et al (1995) noticed that an adult-like N1m response occurred in children when longer ISIs were used (1.2-2.4 s). Ceponiene, Cheour and NiHitiinen (1998) discovered two additional negative components (N160 and 460) besides the N250 in their sample of ' children when ISIs were longer than 2 s. The authors interpreted the fronto-centrally distributed Nl60 as a correlate of the adult NI.…”

Section: ! • •mentioning

confidence: 99%

Reduced hemispheric asymmetry of the auditory N260m in dyslexia

et al. 2006

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Abstract''--..J Dyslexia seems to be related to a lack of planum temporale (PT) asymmetry that is accompanied by functional differences to control subjects in both left and right hemispheric temporal regions during language tasks. PT asymmetry has been found to correlate with phonological and verbal skills. In accordance, reduced asymmetry of the auditory NIOOm sources in dyslexic adults and Ploom sources in dyslexic children has been reported. These results might also be related to an atypical PT symmetry or the recruitment of other structures than the PT for speech processing in dyslexia. In the present study we tried to replicate and extend previous findings by examining a sample of 64 dyslexic and 22 control children in the MEG. We measured cortical activity during a passive auditory oddball-paradigm and localised ERF sources evoked by the standard stimulus Iba/. Reduced hemispheric asymmetry in the localisation of the auditory N260m was revealed. While control children displayed a typical asymmetrical pattern with more anterior sources in the right hemisphere, this asymmetry was not present for the dyslexic children. Further, a correlation between N260m asymmetry and spelling test performance was found. Our results suggest that localisation of ERF components is indeed an applicative tool for investigating cortical deviances in dyslexia. A lack of source localisation asymmetry in dyslexia appears to be a robust finding across different samples of dyslexic children and adults. It appears that cortical auditory (language) processing is organised differently in dyslexic subjects than in controls. This might be the consequence of a more symmetrical PT organisation, which in turn might be the result of maturational delay.

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“…Whereas there is general consensus on how to score ERP/ERF auditory components, the latency and morphology of auditory components across development are only recently being defined. Paetau et al (1995) discuss the changing form of electrophysiological responses to auditory stimulation (using both tones and speech elements) as a function of typical childhood and adolescence development. They noted that auditory components differ as a function of age, and observed a tendency for major ERPs (e.g., N1) to become stronger and to occur at an earlier latency with increasing age.…”

Section: Developmental Trajectory Of M100 Latencymentioning

confidence: 99%

Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders

Roberts

Schmidt

Egeth

et al. 2008

International Journal of Psychophysiology

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While magnetoencephalography (MEG) is of increasing utility in the assessment of pediatric patients with seizure disorders, this indication reflects only a part of the clinical potential of the technology. Beyond epilepsy, a broad range of developmental psychiatric disorders require the combined offerings of spatial and temporal resolution, along with direct sensitivity to neural electrical activity, that are offered by MEG. This article reviews the application of MEG in the study of auditory processing as an aspect of language impairment in children. Potential application is elaborated in the clinical case of autism spectrum disorders, a devastating disorder with prevalence of 1 in 150, poorly served by alternative imaging modalities. MEG offers both spatial and temporal insights, tentatively described as "electrophysiological signatures". Results demonstrate the sensitivity of MEG for detection of abnormalities of auditory processing in ASD and their clinical correlates. These findings offer promise for the comprehensive assessment of developmental neuropsychiatric disorders such as autism, but also suggest avenues for the development of MEG technology to adequately meet the needs of such populations, as well as providing conduits to basic sciences including neurobiology and genetics.

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Auditory Evoked Magnetic Fields to Tones and Pseudowords in Healthy Children and Adults

Cited by 155 publications

References 0 publications

Cortical sound processing in children with autism disorder: an MEG investigation

Cortical sound processing in children with autism disorder: an MEG investigation

Reduced hemispheric asymmetry of the auditory N260m in dyslexia

Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders

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