Auditory Event-Related Potentials in Patients with Systemic Lupus erythematosus

Itô, Junko; Suwazono, Shugo; Kimura, Jun; Shibasaki, Hiroshi

doi:10.1159/000116974

Cited by 9 publications

(7 citation statements)

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“…There were wide variations in the reported prevalence of neurophysiological abnormality in patients with SLE. In our study, the prevalence of neurophysiological abnormalities (83%) among lupus patients was much more than reported in previous studies [8,9,[29][30][31]. This may be related to the fact that there were more neurophysiological tests in our study compared to other studies and also to the duration of the disease since diagnosis.…”

Section: Discussioncontrasting

confidence: 58%

“…Paiva et al [10] found P300 responses to be abnormal in 33% of patients with CNS lupus and in 22% of patients with non-CNS lupus. While Ito et al [29] recorded significant prolongation of P300 in lupus patients compared with controls, 6 out of 17 of their patients (35%) had abnormal values. The discrepancy between the incidence of abnormality may be due to the wide range of normality of P300 latency.…”

Section: Discussionmentioning

confidence: 85%

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Multimodal Electroneurophysiological Studies of Systemic Lupus erythematosus

Khedr

Khedr²,

Farweez³

et al. 2001

Neuropsychobiology

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The purpose of this study was to obtain electrophysiological documentation of possible involvement of central and peripheral nervous system (CNS and PNS) in systemic lupus erythematosus (SLE) patients even in the absence of neurological manifestations. The study included 30 consecutive patients with SLE and 25 age- and sex-matched volunteers as a control group. They were subjected to neurological and rheumatological tests and an extensive battery of neurophysiological tests, besides Wechsler adult intelligence scale. Overt neurological manifestations were observed in 14 patients (46.7%). Neurophysiological data revealed that 25 patients (83%) had at least 2 abnormal tests; 11 (68.8%) patients of the asymptomatic group and 14 patients (100%) of the symptomatic group with no significant differences between them. Seventeen patients (56.7%) had evidence of PNS dysfunction either in nerves (46.7%) or muscles (10%); 7 of them in the asymptomatic group. Twenty-four patients (80%) had evidence of CNS dysfunction. Twenty-two patients (73%) had abnormalities recorded on electroencephalography; 9 patients in the asymptomatic group and 13 patients in the symptomatic group. Eleven patients (37%) had abnormal values of P100 of visual evoked potential; 5 patients in the asymptomatic group and 6 in the symptomatic group. Eight patients (26.7%) had abnormal latency of wave I of brain stem response; 3 of them in the asymptomatic group. Abnormal prolongation of the P300 component of event-related potentials was recorded in 2 patients (12.5%) of the asymptomatic group, while low IQ was observed in 8 patients of each group. Neurophysiological abnormalities are fairly common in SLE patients whether symptomatic or asymptomatic. The use of such tests favors a true incidence of nervous system involvement, more accurate diagnosis, and may lead to better clinical care before the development of debilitating CNS and PNS changes.

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 85%

Multimodal Electroneurophysiological Studies of Systemic Lupus erythematosus

Khedr

Khedr²,

Farweez³

et al. 2001

Neuropsychobiology

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“…Similar abnormalities in the P300 parameters have already been reported in SLE patients, with their frequency ranging from 35% to over 70%. [3][4][5][6] Considering the mainly subcortical localization of CNS lesions in the course of SLE, one could expect more common abnormalities of the N200 component, which is attributed to early, subconscious stimulus processing. Prolonged latency of N200 was less commonly found in our patients than that of the P300 component.…”

Section: Discussionmentioning

confidence: 99%

“…However, ERPs parameters as an electrophysiological index of cognitive function have rarely been investigated in SLE patients. [3][4][5][6] The relationship between different auto-antibodies and NP syndromes in SLE remains a matter under investigation. Some auto-antibodies, such as antiphospholipid, are widely associated with nervous system involvement, while others (e.g., anti-Rib-P and anti-gangliosides) have been the subject of only a few studies and with equivocal results.…”

Section: Introductionmentioning

confidence: 99%

Cognitive impairment, event-related potentials and immunological status in patients with systemic lupus erythematosus

et al. 2019

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Background. Cognitive impairment (CI) is a frequent problem in lupus patients, regardless of their overt neuropsychiatric (NP) involvement. Objectives. The aim of our study was to test cognitive abilities in systemic lupus erythematosus (SLE) patients using neuropsychological testing and event-related potentials (ERPs), and to search for their cognitive abilities correlations with a wide range of auto-antibodies. Material and methods. A total of 37 SLE patients were subjected to a battery of neuropsychological tests, recommended by the American College of Rheumatology (ACR), and to ERPs. They were also tested for a wide range of auto-antibodies (anti-cardiolipin (aCL), anti-β2-glycoprotein I (anti-β2-GPI), lupus anticoagulant, anti-dsDNA, anti-nucleosome, anti-ribosomal P (anti-Rib-P), anti-ganglioside, anti-Ro/SS-A, and anti-La/SS-B. Results. Cognitive impairment was found in 35% of patients, mostly with NP SLE (NPSLE), and was associated with higher disease activity, measured by the SLE Disease Activity Index (SLEDAI), and with a longer duration of central nervous system (CNS) involvement. There were no differences in the immunological status between CI patients and those without cognitive decline, but some antibodies were correlated with worse results in certain neuropsychological tests (anti-dsDNA and worse results of Rey Complex Figure Test-RCFTc for copying and RCFTr for recall, and of verbal fluency test (VFT); aCL IgG and worse results in Digit Span (DS) and in RCFTc). Event-related potentials showed prolonged N200 and P300 latencies in SLE patients in comparison to controls, but no differences were found between SLE and NPSLE patients. Mean P300 latency was significantly longer in patients without anti-nucleosome antibodies. Conclusions. Event-related potentials can be used as a complementary tool in assessing CI in SLE patients. The immunological status of patients with CI did not differ from that of patients without cognitive problems.

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“…La comparación entre grupos, por medio de este potencial ha sido utilizada en diversas situaciones clínicas, con similares interpretaciones respecto a la significación de este hallazgo [23][24][25][26] .…”

Section: Discussionunclassified

Evidencias de compromiso cerebral en el estadio crónico de la enfermedad de Chagas obtenidas por medio del potencial P300 y de electroencefalografía cuantificada

Prost

Villanueva

Morikone

et al. 2000

Arq. Neuro-Psiquiatr.

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RESUMEN -Es reconocido el compromiso del sistema nervioso periférico en la etapa crónica de la enfermedad de Chagas, incorporándose últimamente evidencias tomográficas y neuropsicológicas de compromiso cerebral. Con el objetivo de evaluar dicho compromiso por medio del potencial P 300 y la electroencefalografía cuantificada (EEGc) se estudiaron 35 pacientes (26 a 55 años), comparados con un grupo control de similar número y edad (29 a 55 años). Se observó: latencia de la onda P 3 mayor en el grupo en estudio (331,24 ± 24,02 contra 318,86 ± 23,18) (p=0,01716). El EEGc mostró diferencias en la potencia relativa de la banda Beta 1, menor en los pacientes (p=1,62834E-5) y en la frecuencia dominante, 1 Hz menor en los chagasicos (p=0,01077). El análisis multivariado discrimina tres subpoblaciones: una normal, una de enfermos con incremento alfa y otra de enfermos con decremento alfa e incremento delta y theta (p=0,00004). La proporción de resultados patológicos fue del 20 % en los EEGc y el 11,43 % en los potenciales cognitivos. No se correlacionó el compromiso neurológico y el cardíaco. Se concluye que existen francos indicadores electrofisiológicos de compromiso cerebral en el estadio crónico de la enfermedad de Chagas, hallazgo que refuerza a los obtenidos por otros métodos. PALABRAS-CLAVE: enfermedad de Chagas, sistema nervioso central, potencial p300, electroencefalografía cuantificada (EEGc), mapeo cerebral. P300 event related potentials and qEEG evidenced a cerebral dysfunction in human chronic Chagas diseaseABSTRACT -It is already known the involvement of the peripheral nervous system in chronical stages of Chagas disease. Tomographic and neuropsychological evidence of brain compromise has been included recently. In order to evaluate the neurophysiological counterpart of cerebral involvement, we studied P300 evoked potential and quantified EEG (qEEG) of 35 patients (26-55 years), and compared to an equal number of control subjects (29-55 years). We have found increased P300 latency compared to the control group (331.24 ± 24.02 vs 318.86 ± 23.18) (p=0.01716). qEEG showed lower relative Beta 1 power in the patients group (p=1.6E-5), and the principal frequency 1 Hz slower in the same group (p=0.01077). Multivariate analysis showed three subpopulations: a normal one, pathological one with higher Alpha power and pathological with Alpha decrement and Delta-Theta increment. Pathological findings represented 20% for the qEEG and 11.43% for cognitive potentials. Cardiac and neurologic involvement were not correlated. We conclude that there is clear electrophysiological evidence of cerebral involvement in chronic Chagas disease, thus reinforcing findings obtained by other methods.KEY WORDS: Chagas disease, central nervous system, event related potential P 300, quantitative electroencephalography (qEEG), brain mapping.

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Auditory Event-Related Potentials in Patients with Systemic Lupus erythematosus

Cited by 9 publications

References 0 publications

Multimodal Electroneurophysiological Studies of Systemic Lupus erythematosus

Multimodal Electroneurophysiological Studies of Systemic Lupus erythematosus

Cognitive impairment, event-related potentials and immunological status in patients with systemic lupus erythematosus

Evidencias de compromiso cerebral en el estadio crónico de la enfermedad de Chagas obtenidas por medio del potencial P300 y de electroencefalografía cuantificada

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