Auditory event-related potentials in attention and reading disabled boys

Holcomb, Phillip J.; Ackerman, Peggy T.; Dykman, Roscoe A.

doi:10.1016/0167-8760(86)90035-8

Cited by 142 publications

(90 citation statements)

References 11 publications

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“…The child data demonstrated ERPs broadly similar to those found in our previous child study in this paradigm (Barry and De Blasio, 2012), to our developmental work with the auditory oddball (Johnstone et al, 1996) and non-equiprobable auditory Go/NoGo (Johnstone et al, 2005) tasks, to Holcomb et al (1986), and to Oades et al (1996Oades et al ( , 1997, being particularly characterised by a large frontal N2 and smaller P3 (see dashed traces, left column of Figure 1). The separate child PCA generated a range of components that were similar to the adult data in some respects, and different in others, in line with the apparent adult vs. child ERP differences observed in Figure 1 (left column).…”

Section: Adult Vs Child Pca Outcomessupporting

confidence: 61%

“…In a study of prestimulus EEG phase effects on child ERP peak amplitudes using this paradigm, Barry and De Blasio (2012) reported a large frontocentral P1, frontocentral N1, centroparietal P2, frontocentral N2, and a P3 that was parietal to Go and central to NoGo. The early components were embedded in a large frontal negativity, similar to that found in children by Holcomb et al (1986) using auditory paradigms. They had reported a large early broad negativity (100-300 ms) to targets and non-targets in an oddball task, that appeared to overlap N1, P2 and N2 components, and identified a late frontal negativity (350-700 ms) as the Nc common in children (Courchesne, 1977).…”

Section: Introductionmentioning

confidence: 65%

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Sequential processing in the equiprobable auditory Go/NoGo task: Children vs. adults

Barry

Blasio

Borchard

2014

Clinical Neurophysiology

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Objective To compare sequential processing in the unwarned auditory equiprobable Go/NoGo task in children and adults, in the context of a recently developed adult schema. Methods Adult and child samples completed an equiprobable auditory Go/NoGo task while EEG was recorded from 19 channels. Go and NoGo ERPs were decomposed using unrestricted Varimax-rotated PCAs for the groups separately, and in combination. The separate adult and child components were compared using the Congruence Coefficient. Brain sources of each assessed component were examined using eLORETA. Results Corresponding adult/ child components were tentatively identified: two N1 subcomponents (N1-1, PN) and P2, followed by N2, P3 (separate P3a/P3b in children), the classic Slow Wave (SW), and a diffuse Late Positivity (LP). While early and late components showed similarities, the intermediate P2 and N2 differed substantially in their stimulus effects. Conclusions Aspects of "Go" vs. "NoGo" categorisation differ between adults and children, but subsequent processing reflected in the different Go/NoGo P3 components, and their sequellae, are similar. Significance This is the first detailed examination of child responses in this paradigm. The tested schema appears relatively robust in adults, and the child results may aid our understanding of developmental aspects of cognitive processing in normal and atypical individuals. Methods: Adult and child samples completed an equiprobable auditory Go/NoGo task while EEG was recorded from 19 channels. Go and NoGo ERPs were decomposed using unrestricted Varimax-rotated PCAs for the groups separately, and in combination. The separate adult and child components were compared using the Congruence Coefficient. Brain sources of each assessed component were examined using eLORETA.Results: Corresponding adult/child components were tentatively identified: two N1 subcomponents (N1-1, PN) and P2, followed by N2, P3 (separate P3a/P3b in children), the classic Slow Wave (SW), and a diffuse Late Positivity (LP). While early and late components showed similarities, the intermediate P2 and N2 differed substantially in their stimulus effects.Conclusions: Aspects of "Go" versus "NoGo" categorisation differ between adults and children, but subsequent processing reflected in the different Go/NoGo P3 components, and their sequellae, are similar.Significance: This is the first detailed examination of child responses in this paradigm. The tested schema appears relatively robust in adults, and the child results may aid our understanding of developmental aspects of cognitive processing in normal and atypical individuals. 3 Highlights• Some early and late ERP components show similarities, but Go/NoGo P2 and N2 effects differ with age.• This indicates that aspects of stimulus categorisation differ between children and adults.• Subsequent processing reflected in P3 and later components is similar. 4

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Section: Adult Vs Child Pca Outcomessupporting

confidence: 61%

Section: Introductionmentioning

confidence: 65%

Sequential processing in the equiprobable auditory Go/NoGo task: Children vs. adults

Barry

Blasio

Borchard

2014

Clinical Neurophysiology

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“…Larger P2 amplitudes have also been associated with phasic changes in attention. For example, Holcomb et al (1986) found that P2 amplitude was larger to stimuli that captured more attention. Thus, virally suppressed HIV patients on ART may have generated smaller P2 components than controls because HIV affected the patients' ability to attend to the stimuli.…”

Section: Discussionmentioning

confidence: 99%

ERP evidence of impaired central nervous system function in virally suppressed HIV patients on antiretroviral therapy

Chao

Lindgren

Flenniken

et al. 2004

Clinical Neurophysiology

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Objective-To examine the effects of human immunodeficiency virus (HIV) on central nervous system (CNS) function in patients receiving antiretroviral therapy (ART) who have suppressed viral loads.Methods-Event-related brain potentials (ERPs) were recorded from 15 virally suppressed HIV patients and 15 age-, sex-, and education-matched controls while they performed a 3-stimulus auditory oddball task. The amplitude and latency of the P3a, P3b, and early auditory components were examined in HIV patients and controls.Results-Virally suppressed HIV patients on ART were more depressed than controls, as determined by the Beck Depression Inventory (BDI). After controlling for the effects of depression, HIV patients had smaller P2, P3a, and P3b amplitudes and longer P3a and P3b latency than control subjects. BDI scores correlated positively with N1 latency in HIV patients and negatively with P3b amplitude in all subjects.Conclusions-These electrophysiological results suggest that, even in the absence of detectable levels of HIV in the peripheral blood, viral replication persists in the CNS and continues to cause disease in HIV patients on ART.

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“…Because the P300 indexes awareness of stimulus change, it has been studied in dyslexic individuals in an attempt to characterize potential attentional deficits. For example, Holcomb et al [26] reported a reduction of the P300 effect to a pure tone oddball in dyslexic children and individuals with attention disorder as compared to matched controls. Others, however, have failed to observe this difference [3,14,43].…”

Section: Introductionmentioning

confidence: 99%

Phonological oddballs in the focus of attention elicit a normal P3b in dyslexic adults

Fosker

Thierry

2005

Cognitive Brain Research

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Auditory event-related potentials in attention and reading disabled boys

Cited by 142 publications

References 11 publications

Sequential processing in the equiprobable auditory Go/NoGo task: Children vs. adults

Sequential processing in the equiprobable auditory Go/NoGo task: Children vs. adults

ERP evidence of impaired central nervous system function in virally suppressed HIV patients on antiretroviral therapy

Phonological oddballs in the focus of attention elicit a normal P3b in dyslexic adults

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