Auditory effects on the motor responses after magnetic cortical stimulation and on the H-reflexes in patients with Parkinson's disease

Nakashima, Kenichiro; Wang, Yuping; Shimoda, Manabu; Shimoyama, Reiko; Yokoyama, Yasushi; Takahashi, Kentaro

doi:10.1016/0022-510x(94)90046-9

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…When testing the effect of conditioning MEPs or CMEPs with loud sound, multiple overlapping processes are likely to contribute to the net response facilitation or suppression which is observed. Loud sounds facilitate the H reflex at intervals larger than 50 ms (Rossignol and Jones, 1976;Rudell and Eberle, 1985;Nakashima et al, 1994;Delwaide and Schepens, 1995), indicating an increase in motoneuronal excitability. The suppression of TMS-evoked MEPs seen at the 50 ms interval (Furubayashi et al, 2000;Kuhn et al, 2004;Tazoe and Perez, 2017) must therefore reflect a cortical suppression superimposed on a smaller spinal facilitation.…”

Section: Discussionmentioning

confidence: 98%

Evidence for Subcortical Plasticity after Paired Stimulation from a Wearable Device

Germann

Baker

2021

J. Neurosci.

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Existing non-invasive stimulation protocols can generate plasticity in the motor cortex and its corticospinal projections; techniques for inducing plasticity in sub-cortical circuits and alternative descending pathways such as the reticulospinal tract are less well developed. One possible approach developed by this laboratory pairs electrical muscle stimulation with auditory clicks, using a wearable device to deliver stimuli during normal daily activities. In this study, we applied a variety of electrophysiological assessments to male and female healthy human volunteers during a morning and evening laboratory visit. In the intervening time (~6 hours), subjects wore the stimulation device, receiving three different protocols, in which clicks and stimulation of the biceps muscle were paired at either low or high rate, or delivered at random. Paired stimulation: 1) increased the extent of reaction time shortening by a loud sound (the StartReact effect); 2) decreased the suppression of responses to transcranial magnetic brain stimulation (TMS) following a loud sound; 3) enhanced muscle responses elicited by a TMS coil oriented to induce anterior-posterior (AP) current, but not posterioranterior (PA) current in the brain. These measurements have all been suggested to be sensitive to sub-cortical, possibly reticulospinal, activity. Changes were similar for either of the two paired stimulus rates tested, but absent after unpaired (control) stimulation. Taken together, these results suggest that pairing clicks and muscle stimulation for long periods does indeed induce plasticity in sub-cortical systems such as the reticulospinal tract. Significance StatementSub-cortical systems such as the reticulospinal tract are important motor pathways, which can make a significant contribution to functional recovery after cortical damage such as stroke. Here, we measure changes produced after a novel non-invasive stimulation protocol, 3 which uses a wearable device to stimulate for extended periods. We observed changes in electrophysiological measurements consistent with the induction of sub-cortical plasticity. This protocol may prove an important tool for enhancing motor rehabilitation, in situations where insufficient cortical tissue survives to be a plausible substrate for recovery of function.

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Section: Discussionmentioning

confidence: 98%

Evidence for Subcortical Plasticity after Paired Stimulation from a Wearable Device

Germann

Baker

2021

J. Neurosci.

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“…Estas señales auditivas pueden tener un carácter rítmico, y utilizarse para la caracterización de la estabilidad temporal en la ejecución motora de los movimientos anteriormente mencionados [6,18,[29][30][31][32][33][34][35][36][37][38][39][40][41], o bien tratarse de sonidos simples utilizados como señales preparativas o imperativas para el estudio del tiempo de reacción [42][43][44]. En el primer caso, la utilización de señales auditivas rítmicas (SAR) como marcador que obliga al sujeto a intentar sincronizar sus movimientos con dicha señal, como por ejemplo mediante el golpeo con el dedo índice, se ha comprobado beneficioso en los pacientes con EP, dado que mejora la estabilidad temporal de este movimiento, efecto que no se ha obtenido en los sujetos sanos [6,45].…”

Section: Utilización De Señales Sensoriales Externas Auditivasunclassified

“…Otro efecto comprobado de la estimulación auditiva sobre el movimiento es la reacción de sobresalto, reacción refleja desencadenada por estímulos de diferentes modalidades, aunque generalmente se utiliza un estímulo acústico muy fuerte. La reacción de sobresalto mejora el tiempo de reacción en sujetos sanos y también en pacientes con EP [43,84]. Esta facilitación auditiva por la reacción de sobresalto tendría lugar gracias a un incremento en la actividad neural excitadora en estructuras del tracto reticuloespinal que facilitan o liberan la ejecución de movimientos preprogramados [43].…”

Section: Golpeo Dedo íNdiceunclassified

Facilitación de la actividad motora por estímulos sensoriales en la enfermedad de Parkinson

Olmo

Arias²,

Cudeiro-Mazaira³

2004

RevNeurol

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In this paper we review the most significant studies that deal with the motor enablement experienced by patients with Parkinson's disease in the presence of external rhythmic auditory or visual signals; the different possible causes underlying this enablement are also discussed. Development. The improvements to movement that can be achieved using external stimuli in patients suffering from Parkinson are well documented in the literature. This is why sensory stimulus has become one of the most important points of reference within the rehabilitative strategies that attempt to alleviate the motor difficulties these patients display. Yet, the neurophysiological mechanisms underlying this sensorial enablement have still to be determined. Conclusions. The data we currently have available allows us to consider this type of technique as a useful instrument for improving the motor autonomy of patients with Parkinson and which should be taken into account by health care professionals.

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The deep brain stimulation of the pedunculopontine tegmental nucleus: towards a new stereotactic neurosurgery

et al. 2011

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The application of deep brain stimulation (DBS) to the pedunculopontine tegmental nucleus (PPTg) has required profound modifications of classic neurosurgical techniques and of the criteria for evaluation of clinical results. This review analyzes a novel method of targeting the PPTg, based on angio-computerized tomography (angio-CT) scans and the tridimensional reconstruction of nuclei and cerebral vessels, and considers the advantages of applying these methods in comparison to the more traditional approach based on reference points obtained through the evaluation of the bicommessural line. Validation of the results obtained following unilateral PPTg DBS through neurophysiological recordings and objective measurements of functional parameters suggests that the PPTg may be considered as an initial target for the treatment of motor symptoms in selected patients affected by idiopathic Parkinson's disease (PD), which, if required, could be followed by DBS of other target areas. Moreover, on the basis of the observations derived from stimulating the PPTg, the potential utility attributed up to date to intraoperative neurophysiological recordings for identifying neurosurgical targets should be revisited, and the need for changes in the intraoperative management of patients has arisen from the body of evidence accumulated over recent years. The results obtained by different groups following PPTg DBS in parkinsonian patients are not uniform, most likely due to a cautious acceptance of this methodology, the experience progressively acquired, the criteria for patient selection and to subtle differences in target location. Although the role of PPTg in PD and/or in other pathologies remains to be clarified, pursuing the traditional approach on classical basal ganglia targets may limit the perspective of DBS based on multiple implantations.

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Auditory effects on the motor responses after magnetic cortical stimulation and on the H-reflexes in patients with Parkinson's disease

Cited by 8 publications

References 26 publications

Evidence for Subcortical Plasticity after Paired Stimulation from a Wearable Device

Evidence for Subcortical Plasticity after Paired Stimulation from a Wearable Device

Facilitación de la actividad motora por estímulos sensoriales en la enfermedad de Parkinson

The deep brain stimulation of the pedunculopontine tegmental nucleus: towards a new stereotactic neurosurgery

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