Auditory Dysfunction in Aging and Senile Dementia of the Alzheimer's Type

Gates, George A.; Karzon, Roanne K.; Garcia, P.-Y.; Peterein, J.; Storandt, Martha; Morris, John C.; Miller, J. Philip

doi:10.1001/archneur.1995.00540300108020

Cited by 112 publications

(89 citation statements)

References 39 publications

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“…This contrasts with previous work characterising a generic impairment of auditory scene analysis in AD [33,35,36,[72][73][74][75] and may in part reflect the relatively wide variation in healthy control performance on our tune streaming test (Figure 3). However, it is possible that the analysis of musical scenes benefits to a greater degree than other kinds of auditory scenes from the availability of stored templates, here familiar tunes.…”

Section: Europe Pmc Funders Author Manuscriptscontrasting

confidence: 99%

“…Such an analysis is fundamental to the initial parsing of a musical 'scene', before more detailed analysis can occur [7]; it is likely to entail an interaction of bottom-up mechanisms for coding perceptual structure with top-down mechanisms for resolving perceptual ambiguities based on stored templates or schemas derived from past experience of music [5,67]. Musical scene analysis has not been widely studied neuropsychologically in clinical populations but is likely to engage posterior superior temporal and parietal lobe regions and their dorsal projections [68][69][70][71][72]. AD has been shown to produce a generic impairment of auditory scene analysis under diverse listening tasks and conditions, including the streaming of sound sequences that bear some similarities to musical melodies; this has been linked to dysfunction of posterior temporoparietal areas overlapping those involved in music perception [33,35,36,[73][74][75].…”

Section: Introductionmentioning

confidence: 99%

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Music Perception in Dementia

Golden

Clark

Nicholas

et al. 2016

JAD

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# These authors contributed equally to this work. AbstractDespite much recent interest in music and dementia, music perception has not been widely studied across dementia syndromes using an information processing approach. Here we addressed this issue in a cohort of 30 patients representing major dementia syndromes of typical Alzheimer's disease (AD, n=16), logopenic aphasia (LPA, an Alzheimer variant syndrome; n=5) and progressive nonfluent aphasia (PNFA; n=9) in relation to 19 healthy age-matched individuals. We designed a novel neuropsychological battery to assess perception of musical patterns in the dimensions of pitch and temporal information (requiring detection of notes that deviated from the established pattern based on local or global sequence features) and musical scene analysis (requiring detection of a familiar tune within polyphonic harmony). Performance on these tests was referenced to generic auditory (timbral) deviance detection and recognition of familiar tunes and adjusted for general auditory working memory performance. Relative to healthy controls, patients with AD and LPA had group-level deficits of global pitch (melody contour) processing while patients with PNFA as a group had deficits of local (interval) as well as global pitch processing. There was substantial individual variation within syndromic groups. No specific deficits of musical temporal processing, timbre processing, musical scene analysis or tune recognition were identified. The findings suggest that particular aspects of music perception such as pitch pattern analysis may open a window on the processing of information streams in major dementia syndromes. The potential selectivity of musical deficits for particular dementia syndromes and particular dimensions of processing warrants further systematic investigation.

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Section: Europe Pmc Funders Author Manuscriptscontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Music Perception in Dementia

Golden

Clark

Nicholas

et al. 2016

JAD

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“…In addition, this stage is characterized by a decline in recent memory and difficulty in processing simultaneously competing auditory stimuli. 40 Persons may be unaware or not fully comprehend their limitation and severity of cognitive deficit.…”

Section: Early Dementiamentioning

confidence: 99%

Neurologic Conditions: Assessing Medical Fitness to Drive

Yale¹,

Hansotia²,

Knapp³

et al. 2003

Clinical Medicine & Research

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Clinicians are often asked to make an assessment on whether a patient is medically fit to drive, even though few have been formally trained in this area. Driving is a complex task that requires having adequate operational, cognitive and higher executive functions that work together. These functions can be compromised to a greater or lesser extent in neurological disorders, such as stroke, traumatic brain injury, peripheral neuropathy, dementia, Parkinson's disease and epilepsy. There is insufficient standardized information relating to impaired function at this time. Because of this, state laws vary in their assessment of medical conditions as they relate to driver licensing. Wisconsin laws are reviewed as an example. There are numerous assessment tests for various functions, but they lack a validated correlation with actual driving performance. These and other factors, as well as practical recommendations for the practicing physicians, are the subjects of this review.

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“…It is well known that aging is associated with significant declines in hearing thresholds, as well as in the ability to identify and remember spoken words; there is also evidence that supra-threshold functions, such as frequency, intensity, and temporal discrimination, may be impaired in older listeners and that these impairments may adversely affect speech perception, especially under degraded listening conditions [19][20][21] .…”

Section: Discussionmentioning

confidence: 99%

Speech Audiometry Tests in Noise Are Impaired in Older Patients with Mild Cognitive Impairment: A Pilot Study

Aimoni¹,

Prosser²,

Ciorba³

et al. 2015

Int Adv Otol

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OBJECTIVE:Mild cognitive impairment (MCI) is a frequent condition in the older population; its early diagnosis might be particularly important for the prevention of dementia onset. In particular, the aim of this study is to evaluate whether speech recognition in noise might be impaired in older patients with MCI compared with normal older individuals. MATERIALS and METHODS:On the whole, 48 subjects were enrolled into the present study: 16 older patients with MCI, 16 older subjects without cognitive impairment (controls), and 16 normally hearing young individuals. All subjects underwent speech audiometry in noise in order to evaluate the effect of different types of masking: two kinds of energetic masking, stationary and fluctuating noise, and a kind of typical informative masking, consisting of continuous discourse. RESULTS:The signal-to-noise ratio (S/N), expressed in dB, needed for speech reception threshold (SRT) in noise was worse in older patients affected by MCI, compared with older controls. The presence of masking likely affected the performance of both elderly controls and MCI patients; however, elderly controls had better performance with informative masking (CoDi) than MCI patients. CONCLUSION:Speech audiometry tests in noise are impaired in MCI older patients, and this could indicate a particular decline in functions associated with selective attention in these individuals. If confirmed in a larger sample of patients, these simple tests might contribute to the early identification of MCI patients.

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Auditory Dysfunction in Aging and Senile Dementia of the Alzheimer's Type

Cited by 112 publications

References 39 publications

Music Perception in Dementia

Music Perception in Dementia

Neurologic Conditions: Assessing Medical Fitness to Drive

Speech Audiometry Tests in Noise Are Impaired in Older Patients with Mild Cognitive Impairment: A Pilot Study

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