Auditory Deprivation and Its Consequences: From Animal Models to Humans

Gravel, Judith S.; Ruben, Robert J.

doi:10.1007/978-1-4612-4068-6_4

Cited by 13 publications

(5 citation statements)

References 86 publications

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“…The effects of acoustic environment on the synaptic development of the VCN have not been described, but the debilitating effects of reduced auditory input are well established (reviewed by Gravel and Ruben 1996;Moore and King 2004;Shepherd et al 2006). Much of this work has focused on the abnormal ultrastructural features of endbulbs in congenitally deaf animals (Ryugo et al 1996;Ryugo et al 1997;FIG.…”

Section: Alterations Of Synaptic Transmission In the Auditory Nerve Amentioning

confidence: 99%

“…A history of mild conductive loss can impede the refinement of higher-order cognitive processes, such as, speech recognition, auditory memory, and sound segregation (Gravel and Ruben 1996). Disordered patterns of speech and language development can be reversed by the timely initiation of aided auditory function in deaf children Shepherd et al 2006).…”

Section: Introductionmentioning

confidence: 99%

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The Medial Olivocochlear System Attenuates the Developmental Impact of Early Noise Exposure

Lauer

May

2011

JARO

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The early onset of peripheral deafness profoundly alters the functional maturation of the central auditory system. A prolonged exposure to an artificial acoustic environment has a similar disruptive influence. These observations establish the importance of normal patterns of sound-driven activity during the initial stages of auditory development. The present study was designed to address the role of cochlear gain control during these activity-dependent developmental processes. It was hypothesized that the regulation of auditory nerve activity by the medial olivocochlear system (MOCS) would preserve normal development when the immature auditory system was challenged by continuous background noise. To test this hypothesis, knock-out mice lacking MOCS feedback were reared in noisy or quiet environments and then evaluated with behavioral paradigms for auditory processing deficits. Relative to wild-type controls, noise-reared knock-out mice showed a decreased ability to process rapid acoustic events. Additional anatomical and physiological assessments linked these perceptual deficits to synaptic defects in the auditory brainstem that shared important features with human auditory neuropathy. Our findings offer a new perspective on the potentially damaging effects of environmental noise and how these risks are ameliorated by the protective role of MOCS feedback.

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Section: Alterations Of Synaptic Transmission In the Auditory Nerve Amentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Medial Olivocochlear System Attenuates the Developmental Impact of Early Noise Exposure

Lauer

May

2011

JARO

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“…14,15 To help identifying the gene that play a role in human's auditory system, a rat is used as an experimental animal since it is genetically similar to a human (>70%). 16 The objective of this study is to learn the role of curcumin in decreasing the PKC expressions in the cochlear fibroblasts of diabetic rats (Rattus novergicus).…”

Section: Resultsmentioning

confidence: 99%

Decreased Protein Kinase C expressions in the cochlear fibroblasts of diabetic rat models induced by curcumin

Haryuna¹,

Farhat²,

Indriany³

2018

tjps

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INTRODUCTION:Microcirculation and hemodynamic disturbances, including in the cochlea, are commonly found in diabetic patients. A study on diabetic rats discovered the histopathological changes in outer hair cells, spiral ganglion and mitochondrial damage in the ear. Hyperglycemia can increase the activation of Protein Kinase C (PKC). Curcumin as an antioxidant also affects the regulation of PKC and Ca2+. The aim of this study is to learn the role of curcumin in decreasing the PKC expressions in the cochlear fibroblasts of diabetic rats. METHODS:An experimental study on 24 Wistar rats divided into 6 groups.Group 1: control group; group 2: diabetic group without curcumin administration; group 3 and 4: diabetic groups with curcumin administration (200 mg/kgbw and 400 mg/kgbw for 3 days, respectively); group 5 and 6: diabetic groups with curcumin administration (200 mg/kgbw and 400 mg/kgbw for 8 days, respectively). Cochlear tissues were taken from all groups and immunohistochemistry-stained, and the PKC expression scores were analysed with One-Way ANOVA (a significance level of 0.05). RESULTS:Significant differences in PKC expressions (p<0.05) were found between group 1 and group 2, group 2 and group 3, 4, 5, 6. There was no significant difference in PKC expression regarding the different doses and the duration of curcumin administration. DISCUSSION AND CONCLUSION: Curcumin can reduce the PKC expressionsin the cochlear fibroblasts of diabetic rats.

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“…14,15 To help identify the gene that plays a role in the human auditory system, rats were used as the experimental animal since they are genetically similar to humans (>70%). 16 The objective of this study was to determine the role of curcumin in decreasing PKC expression in the cochlear fibroblasts of diabetic rats (R. norvegicus).…”

Section: Discussionmentioning

confidence: 99%

Decreased Protein Kinase C Expression in the Cochlear Fibroblasts of Diabetic Rat Models Induced by Curcumin

Haryuna¹,

Farhat²,

Indriany³

2019

tjps

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Kokleada dahil olmak üzere mikrodolaşım ve hemodinamik bozukluklar, diyabetli hastalarda yaygın olarak görülür. Diyabetik sıçanlar üzerine yapılan bir çalışma, dıştaki saç hücrelerindeki histopatolojik değişiklikleri, sarmal gangliyon ve kulaktaki mitokondriyal hasarı ortaya koymuştur. Hiperglisemi, protein kinaz C (PKC) aktivasyonunu artırabilir. Bir antioksidan olan kurkumin, PKC ve Ca 2+ düzenini de etkiler. Bu çalışmanın amacı, diyabetik sıçanlarda koklear fibroblastlarda PKC ekspresyonlarının azaltılmasında kurkuminin rolünü öğrenmektir. Gereç ve Yöntemler: Yirmi dört adet Wistar sıçan 6 gruba ayrılmıştır. Grup 1: kontrol grubu; grup 2: kurkumin uygulanmayan diyabetik grup; grup 3 ve 4: kurkumin uygulanan diyabetik gruplar (sırasıyla 3 gün süreyle 200 mg/kg ve 400 mg/kg); grup 5 ve 6: kurkumin uygulaması olan diyabetik gruplar (sırasıyla 8 gün boyunca 200 mg/kg ve 400 mg/kg). Koklear dokular tüm gruplardan alındı ve immünohistokimyasal olarak boyandı ve PKC ekspresyon skorları, tek-yönlü ANOVA (0.05'lik önem derecesi) ile analiz edildi. Bulgular: Grup 1 ile grup 2, grup 2 ve grup 3, 4, 5, 6 arasında PKC ekspresyonlarında önemli farklılıklar bulundu (p<0.05). Farklı dozlar ve kurkuminin uygulama süresi ile ilgili olarak PKC ekspresyonunda önemli bir fark yoktu. Sonuç: Kurkumin, diyabetik sıçanların koklear fibroblastlarındaki PKC ekspresyonlarını azaltabilir.

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Auditory Deprivation and Its Consequences: From Animal Models to Humans

Cited by 13 publications

References 86 publications

The Medial Olivocochlear System Attenuates the Developmental Impact of Early Noise Exposure

The Medial Olivocochlear System Attenuates the Developmental Impact of Early Noise Exposure

Decreased Protein Kinase C expressions in the cochlear fibroblasts of diabetic rat models induced by curcumin

Decreased Protein Kinase C Expression in the Cochlear Fibroblasts of Diabetic Rat Models Induced by Curcumin

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