Auditory Brainstem Response (ABR) in Spontaneously Epileptic Rats (SER) and Their Parent Mutants.

Kuse, Hiroshi; Inui, Toshiya; Asano, Y.; Hori, Masaki; Okaniwa, Azusa; Serikawa, Tadao; Yamada, Junzo

doi:10.1292/jvms.53.629

Cited by 2 publications

(1 citation statement)

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“…Furthermore, a large number of BAEP components are recordable, and using click stimuli a lower stimulus intensity, compared with the intensity required by tone burst stimuli can elicit BAEPs [14,24]. Clicks consisting of 0.1-msec square waves or 10-kHz single sine waves have commonly been used for BAEP recordings [8,25,29]; however, the effects of changes in click frequency on BAEPs have not so far been evaluated. Therefore, we considered it to be useful for preclinical ototoxicity research utilizing BAEPs to examine the effects of click frequency on BAEPs.…”

Section: Subjectsmentioning

confidence: 99%

Effects of Click Intensity and Frequency on the Brain-Stem Auditory Evoked Potentials in the Common Marmoset (Callithrix jacchus).

Harada

Tokuriki

1997

The Journal of Veterinary Medical Science

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ABSTRACT. Brain-stem auditory evoked potentials (BAEPs) were recorded in 20 common marmosets (Callithrix jacchus) to investigate the effects of click frequency up to 99 kHz, in consideration of the higher hearing range of the marmoset, and intensity on wave forms and peak latencies. According to the results of BAEP recordings at frequencies of 4, 32, and 99 kHz, the number of components recorded was affected by the stimulus intensity and the clicks at an intensity of 80 dB peak equivalent sound pressure level (pe SPL) had the maximum number of clear components. Therefore, it was indicated that click stimulations at an intensity of 80 dB pe SPL over a broad range of frequencies appears to be useful for recording the maximum number of components in marmosets and may increase the information obtainable from BAEPs. BAEP latencies were prolonged as the stimulus intensity decreased from 100 to 50 dB pe SPL. The effects of stimulus frequency on the wave latencies and amplitudes in response to 80 dB pe SPL at frequencies between 0.5 and 99 kHz revealed various changes: the amplitude of wave I increased at 16 and 32 kHz, but that of waves III and V increased at 4-8 and 64-99 kHz. These increases in amplitudes of the waves may correlate with higher synchronous activity of the peripheral or central auditory pathways. -KEY WORDS: brain-stem auditory evoked potential (BAEP), click stimulation, marmoset, stimulus frequency, stimulus intensity.

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Section: Subjectsmentioning

confidence: 99%