Auditory brainstem implants: current state and future directions with special reference to the subtonsillar approach for implantation

Seki, Yojiro; Samejima, N; Komatsuzaki, Atsushi

doi:10.1007/978-3-211-33081-4_49

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…However, some persons with deafness cannot benefit from cochlear implants due to traumatic injury to the auditory nerve, to auditory nerve tumors, or to ossification or malformation of the cochlea. When both cochlea or auditory nerves are so afflicted, useful hearing may be restored by stimulating electrodes implanted onto the surface of the cochlear nucleus (Bento et al 2008; Colletti et al 2004; Colletti et al 2005; Colletti et al 2002; Colletti et al 2009b; Edgerton et al 1982; Grayeli et al 2007; House and Hitselberger 2001; Lenarz et al 2006; Maini et al 2009; McCreery 2008; Otto et al 2002; Schwartz et al 2003; Seki et al 2007; Vincenti et al 2008; Xiao et al 2007). The quality of the hearing provided by these Auditory Brainstem Implants (ABIs) differs across users and for the etiology of the hearing loss but in most cases is sufficient to assist with lip reading and for detection and differentiation of many environmental sounds.…”

Section: Introductionmentioning

confidence: 99%

Responses of neurons in the feline inferior colliculus to modulated electrical stimuli applied on and within the ventral cochlear nucleus; Implications for an advanced auditory brainstem implant

2018

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Auditory brainstem implants (ABIs) can restore useful hearing to persons with deafness who cannot benefit from cochlear implants. However, the quality of hearing restored by ABIs rarely is comparable to that provided by cochlear implants in persons for whom those are appropriate. In an animal model, we evaluated elements of a prototype of an ABI in which the functions of macroelectrodes on the surface of the dorsal cochlear nucleus would be integrated with the function of multiple penetrating microelectrodes implanted into the ventral cochlear nucleus. The surface electrodes would convey most of the range of loudness percepts while the intranuclear microelectrodes would sharpen and focus pitch percepts. In the present study, stimulating electrodes were implanted chronically on the surface of the animal's dorsal cochlear nucleus (DCN) and also within their ventral cochlear nucleus (VCN). Recording microelectrodes were implanted into the central nucleus of the inferior colliculus (ICC). The electrical stimuli were sinusoidally modulated stimulus pulse trains applied on the DCN and within the VCN. Temporal encoding of neuronal responses was quantified as vector strength (VS) and as full-cycle rate of neuronal activity in the ICC. VS and full-cycle AP rate were measured for 4 stimulation modes; continuous and transient amplitude modulation of the stimulus pulse trains, each delivered via the macroelectrode on the surface of the DCN and then by the intranuclear penetrating microelectrodes. In the proposed clinical device the functions of the surface and intranuclear microelectrodes could best be integrated if there is minimal variation in the neuronal responses across the range of modulation depth, modulation frequencies, and across the four stimulation modes. In this study VS did vary as much as 34% across modulation frequency and modulation depth within a stimulation mode, and up to 40% between modulation modes. However, these intra- and inter-mode variances differed for different stimulation rates, and at 500 Hz the inter-mode differences in VS and across the range of modulation frequencies and modulation depths was = 24% and the intra-modal differences were = 15%. The findings were generally similar for rate encoding of modulation depth, although the depth of transient amplitude modulation delivered by the surface electrode was weakly encoded as full-cycle rate. Overall, our findings support the concept of a clinical ABI that employs surface stimulation and intranuclear microstimulation in an integrated manner.

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Section: Introductionmentioning

confidence: 99%

Responses of neurons in the feline inferior colliculus to modulated electrical stimuli applied on and within the ventral cochlear nucleus; Implications for an advanced auditory brainstem implant

2018

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“…Approximately two weeks after implanting the stimulating array, an array of recording microelectrodes was implanted into the cats' left ICC [26]. The array contains 16 recording sites, each with a surface area of 2000 μm 2 . In one cat, the recording sites were integrated onto two silicon shanks and sputter-coated with iridium oxide [27].…”

Section: Methodsmentioning

confidence: 99%

“…NF2 is quite rare, but worldwide there are many thousands of persons afflicted with the disorder. In recent years, the indications for the ABI have expanded beyond NF2, to include persons with bilateral deafness of other etiologies that preclude a cochlear implant, including bilateral cochlear ossification, unilateral vestibular schwannoma in combination with deafness in the contralateral ear that is not amenable to a cochlear implant, congenital cochlear nerve aplasia or hypoplasia, and bilateral traumatic avulsions of the cochlear nerve [1][2][3]. Dr Vittorio Colletti and colleagues [4] have described ABI patients whose deafness is of etiologies other than NF2.…”

Section: Introductionmentioning

confidence: 99%

Encoding of the amplitude modulation of pulsatile electrical stimulation in the feline cochlear nucleus by neurons in the inferior colliculus; effects of stimulus pulse rate

McCreery¹,

Han²,

Pikov³

et al. 2013

J. Neural Eng.

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“…When the nerve is damaged or otherwise inoperable, auditory brainstem implants (ABIs), penetrating auditory brainstem implants (PABIs), and auditory midbrain implants (AMIs), also shown in Fig. 1, can be used to stimulate targets of the central auditory pathway including the cochlear nucleus (CN) and the inferior colliculus (IC) (Lim et al, 2008;McCreery et al, 2007;McCreery, 2008;Middlebrooks and Snyder, 2008;Seki et al, 2007).…”

Section: Auditory Prosthetic Devices and Drug Deliverymentioning

confidence: 99%

Localized cell and drug delivery for auditory prostheses

et al. 2008

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Localized cell and drug delivery to the cochlea and central auditory pathway can improve the safety and performance of implanted auditory prostheses (APs). While generally successful, these devices have a number of limitations and adverse effects including limited tonal and dynamic ranges, channel interactions, unwanted stimulation of non-auditory nerves, immune rejection, and infections including meningitis. Many of these limitations are associated with the tissue reactions to implanted auditory prosthetic devices and the gradual degeneration of the auditory system following deafness. Strategies to reduce the insertion trauma, degeneration of target neurons, fibrous and bony tissue encapsulation, and immune activation can improve the viability of tissue required for AP function as well as improve the resolution of stimulation for reduced channel interaction and improved place-pitch and level discrimination. Many pharmaceutical compounds have been identified that promote the viability of auditory tissue and prevent inflammation and infection. Cell delivery and gene therapy have provided promising results for treating hearing loss and reversing degeneration. Currently, many clinical and experimental methods can produce extremely localized and sustained drug delivery to address AP limitations. These methods provide better control over drug concentrations while eliminating the adverse effects of systemic delivery. Many of these drug delivery techniques can be integrated into modern auditory prosthetic devices to optimize the tissue response to the implanted device and reduce the risk of infection or rejection. Together, these methods and pharmaceutical agents can be used to optimize the tissue-device interface for improved AP safety and effectiveness.

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Auditory brainstem implants: current state and future directions with special reference to the subtonsillar approach for implantation

Cited by 5 publications

References 10 publications

Responses of neurons in the feline inferior colliculus to modulated electrical stimuli applied on and within the ventral cochlear nucleus; Implications for an advanced auditory brainstem implant

Responses of neurons in the feline inferior colliculus to modulated electrical stimuli applied on and within the ventral cochlear nucleus; Implications for an advanced auditory brainstem implant

Encoding of the amplitude modulation of pulsatile electrical stimulation in the feline cochlear nucleus by neurons in the inferior colliculus; effects of stimulus pulse rate

Localized cell and drug delivery for auditory prostheses

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