Auditory brainstem implant in auditory rehabilitation of patients with neurofibromatosis type 2: Hannover

Lesinski‐Schiedat, Anke; Frohne, C.; Illg, Angelika; Rost, U; Matthies, Cordula; Battmer, R. D.; Samii, Madjid; Lenarz, Thomas

doi:10.1258/0022215001904806

Cited by 18 publications

(13 citation statements)

References 9 publications

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“…Once implanted with an ABI, there is large variability in outcomes. Interestingly, tumour size does not always relate to ABI outcomes [Lesinski-Schiedat et al, 2000]. Rather, the resulting impact of brainstem compression on the cochlear nuclei may account for the varying ABI outcomes for NF2 patients with different tumour sizes.…”

Section: Discussionmentioning

confidence: 98%

“…Bouccara et al, 2007;Lesinski-Schiedat et al, 2000;Matthies et al, 2000]. More favourable ABI outcomes have been reported for NF2 patients with a shorter duration of hearing loss, smaller tumour size, and a higher number of active electrodes [Bouccara et al, 2007].…”

Section: Introductionmentioning

confidence: 99%

“…More favourable ABI outcomes have been reported for NF2 patients with a shorter duration of hearing loss, smaller tumour size, and a higher number of active electrodes [Bouccara et al, 2007]. However, other studies have found no association between ABI outcomes and duration of hearing loss or tumour size [Lesinski-Schiedat et al, 2000]. Another potentially important factor in determining ABI outcomes for NF2 patients is brainstem compression.…”

Section: Introductionmentioning

confidence: 99%

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Acute Cochlear Nucleus Compression Alters Tuning Properties of Inferior Colliculus Neurons

Crea¹,

Shivdasani²,

Argent

et al. 2009

Audiol Neurotol

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Auditory brainstem implants (ABI) have been used in neurofibromatosis type 2 (NF2) patients in an attempt to restore hearing sensation, with limited clinical success. Factors associated with poor clinical outcomes for NF2 ABI patients include larger tumour size, longer duration of hearing loss, and brainstem distortion and/or deformation caused by tumours that compress the brainstem. The present study investigated changes in tuning properties of inferior colliculus (IC) neurons following compression of the contralateral cochlear nucleus (CN). The left CN in adult rats (n = 8) was exposed and a 32-channel acute recording probe inserted along the tonotopic gradient of the right IC. In 4 animals, an ethylene vinyl acetate bead was applied to the exposed CN. Three recordings were made corresponding to T₁ = 0 min (before compression), T₂ = 45 min (during compression) and T₃ = 225 min (following bead removal/recovery). Recordings consisted of a response area protocol using pure tones of various frequencies and intensities (1–44 kHz; 10–70 dB SPL) to determine the characteristic frequency for each probe site. Compression of the CN led to sharpened tuning curves, decreased spike rate, and increased threshold and characteristic frequency in the IC. Reversal of compression enabled these variables, excluding threshold, to recover to baseline. NF2 patients may have poorer ABI performance due to damage to the physical structure of the CN, resulting in alterations to the tonotopic organisation of the auditory pathway which may complicate ABI implantation and activation.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute Cochlear Nucleus Compression Alters Tuning Properties of Inferior Colliculus Neurons

Crea¹,

Shivdasani²,

Argent

et al. 2009

Audiol Neurotol

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show abstract

“…This is likely to occur due to a continued learning effect following ABI activation. Likewise, several authors indicate that the success of the NF2 patients with hearing loss in rehabilitation is most obvious upon long-term follow-up [20,40]. …”

Section: Discussionmentioning

confidence: 99%

Auditory Brainstem Implantation Improves Speech Recognition in Neurofibromatosis Type II Patients

Matthies¹,

Brill

Kaga

et al. 2013

ORL

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This prospective study aimed to determine speech understanding in neurofibromatosis type II (NF2) patients following implantation of a MED-EL COMBI 40+ auditory brainstem implant (ABI). Patients (n = 32) were enrolled postsurgically. Nonauditory side effects were evaluated at fitting and audiological performance was determined using the Sound Effects Recognition Test (SERT), Monosyllable-Trochee-Polysyllable (MTP) test and open-set sentence tests. Subjective benefits were determined by questionnaire. ABI activation was documented in 27 patients, 2 patients were too ill for testing and 3 patients were without any auditory perception. SERT and MTP outcomes under auditory-only conditions improved significantly between first fitting and 12-month follow-up. Open-set sentence recognition improved from 5% at first fitting to 37% after 12 months. The number of active electrodes had no significant effect on performance. All questionnaire respondents were ‘satisfied' to ‘very satisfied' with their ABI. An ABI is an effective treatment option in NF2 patients with the potential to provide open-set speech recognition and subjective benefits. To our knowledge, the data presented herein is exceptional in terms of the open-set speech perception achieved in NF2 patients.

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“…Functional results show great variability; from noise perception only to useful speech discrimination in audiovisual mode in a few patients so far. Since the early trials by Hitselberger and House in 1979, as reported by Edgerton et al 13 and Hit sel berger et al, 21 profound improvements in implant array, technology, and speech processing strategies 65 have brought about useful improvement in functional outcome, 4,8,9,17,23,29,31,32,37,42,43,45,46,48,58,59 but still results remain less favorable than in cochlear implants or auditory brainstem implants (ABIs) in patients without NF2. 8 Visionindependent speech perception is not generally achieved.…”

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confidence: 99%

Auditory brainstem implants in neurofibromatosis Type 2: is open speech perception feasible?

Matthies¹,

Brill²,

Várallyay

et al. 2014

JNS

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Object Patients with bilateral auditory nerve destruction may perceive some auditory input with auditory brainstem implants (ABIs). Despite technological developments and trials in new stimulation sites, hearing is very variable and of limited quality. The goal of this study was to identify advantageous and critical factors that influence the quality of auditory function, especially speech perception. Methods The authors conducted a prospective study on ABI operations performed with the aid of multimodality neuromonitoring between 2005 and 2009 in 18 patients with neurofibromatosis Type 2. Outcome was evaluated by testing word recognition (monotrochee-polysyllabic word test at auditory-only mode [MTPa]) and open speech perception (Hochmair-Schulz-Moser [HSM] sentence test), both in pure auditory mode. The primary outcome was the HSM score at 24 months. The predictive meaning of general clinical data, tumor volume, number of active electrodes, duration of deafness, and early hearing data was examined. Results In 16 successful ABI activations the average score for MTPa was 89% (SD 13%), and for HSM it was 41% (SD 32%) at 24 months. There were 2 nonresponders, 1 after radiosurgery and the other in an anatomical variant. Direct facial nerve reconstruction during the same surgery was followed by successful nerve recovery in 2 patients, with a simultaneous very good HSM result. Patients' age, tumor extension, and tumor volume were not negative predictors. There was an inverse relationship between HSM scores and deafness duration; 50% or higher HSM scores were found only in patients with ipsilateral deafness duration up to 24 months. The higher the deafness sum of both sides, the less likely that any HSM score will be achieved (p = 0.034). In patients with total deafness duration of less than 240 months, higher numbers of active electrodes were significantly associated with better outcomes. The strongest cross-correlation was identified between early MTPa score at 3 months and 24-month HSM outcome. Conclusions This study documents that open-set speech recognition in pure auditory mode is feasible in patients with ABIs. Large tumor volumes do not prevent good outcome. Positive preconditions are short ipsilateral and short bilateral deafness periods and high number of auditory electrodes. Early ability in pure auditory word recognition tests indicates long-term capability of open speech perception.

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Auditory brainstem implant in auditory rehabilitation of patients with neurofibromatosis type 2: Hannover

Cited by 18 publications

References 9 publications

Acute Cochlear Nucleus Compression Alters Tuning Properties of Inferior Colliculus Neurons

Acute Cochlear Nucleus Compression Alters Tuning Properties of Inferior Colliculus Neurons

Auditory Brainstem Implantation Improves Speech Recognition in Neurofibromatosis Type II Patients

Auditory brainstem implants in neurofibromatosis Type 2: is open speech perception feasible?

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