Auditory Brainstem Evoked Potentials in Insulin-dependent Diabetics with and without Peripheral Neuropathy

Goldsher, Moshe; Pratt, Hillel; Hassan, Amal G; R, Shenhav; Eliachar, Isaac; Kanter, Y

doi:10.3109/00016488609108667

Cited by 45 publications

(30 citation statements)

References 12 publications

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“…The latest results provide similar conclusions [25,26]. But there are also reports showing no disturbances in peripheral and central hearing organ in diabetes [14,27,28].…”

Section: Discussionsupporting

confidence: 72%

Are there any disturbances in vestibular organ of children and young adults with Type I diabetes?

et al. 2002

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Aims/hypothesis. The aim of the work was to evaluate the vestibular organ condition in children and young adults suffering from Type I (insulin-dependent) diabetes mellitus. Methods. The group examined consisted of 95 children and young adults aged from 6 to 28 years with Type I diabetes diagnosed. The diabetic group was divided into subgroups according to duration of the disease, compensation of the disease, and presence and character of hypoglycaemic incidents, and presence of diabetic complications. The control group consisted of 44 healthy children and young adults aged 6 to 28 years. After collecting detailed medical history in each case an electronystagmographic test was performed using the computed two-canal electronystagmographer. Results. Within the diabetic group 6 patients complained about vertigo and balance disorders. Spontaneous nystagmus occurred in 10 cases, positional one in 21 cases. Impaired optokinesis occurred in 36 cases and impaired eye tracking test in 33 cases. In caloric tests there was partial canal paresis in 4 cases and directional preponderance in 7 cases. Conclusion/interpretation. Metabolic disturbances present in Type I diabetes cause disturbances in different parts of vestibular organ but mostly in its central part. Comparing disturbances in the vestibular organ with clinical and biochemical parameters characterising diabetes, the range of vestibular organ impairment in diabetes mellitus type 1 seems to depend mainly on the presence and character of hypoglycaemic incidents and the duration of the disease and to some extent on the compensation of diabetes. [Diabetologia (2002) 45:728-734]

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“…The latest results provide similar conclusions [25,26]. But there are also reports showing no disturbances in peripheral and central hearing organ in diabetes [14,27,28].…”

Section: Discussionsupporting

confidence: 72%

Are there any disturbances in vestibular organ of children and young adults with Type I diabetes?

et al. 2002

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“…[27] At present study, when we compared diabetic patients with and without peripheral neuropathy, we observed that at 80 dB, there was significant delay in Waves I and V latencies in left ear and significant delay in interpeak latencies I-V in left ear, whereas, for 90 dB, there was not any significant alteration in the entire wave of absolute latencies as well as interpeak latency difference. The previous study [30] compared 25 diabetics with peripheral neuropathy and 15 diabetics without peripheral neuropathy and observed delay in absolute latencies of Waves III and V with prolonged interpeak latencies I-III and I-V in diabetic with peripheral neuropathy as compared with diabetic without neuropathy. Symmetrical sensorineural deafness was also observed in 55% of Type II diabetes patients with neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of auditory evoked response among type-II diabetic individuals in central India

Batham¹,

Choudhary²,

Yousuf³

2017

Natl J Physiol Pharm Pharmacol

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Background:The Type II diabetes mellitus (DM) is characterized by hyperglycemia, as a result of damaged beta cell function, along with increase insulin resistance, either at receptor or at postreceptor levels. Neuropathies complications are the most common in diabetes, that's may lead to delayed evoked potentials in the central pathways. Aims and Objective: This study was undertaken to know the hearing status of the Type II diabetic patients and to delay development of its related complication like central neuropathy. Materials and Methods: This study evaluates central neuropathy by brainstem evoked response audiometry (BERA) in Type II DM patients. Results: We observed significant differences in BERA latencies between diabetic patients and healthy controls. There was significantly delayed Wave II, IV latency in left ear (at 80 dB) and Wave II latency in left ear, as well as Wave IV latency in right ear (at 90 dB) as compared to control. Diabetics patients with and without peripheral neuropathy there were absolute delayed latencies of Wave I, III, and V (80 dB). With relation to blood glucose, a significant difference in absolute latencies of Wave II (right ear at 90 dB), Wave IV (in right ear at 90 dB), Wave V (left ear at 80 dB), and interpeak latencies I-V (in right ear at 90 band). Conclusion: This study suggests that BERA is a simple, non-invasive procedure to detect early impairment of acoustic nerve, and central nervous system pathways, even in the absence of specific symptoms, if BERA is carried out in diabetic patients, involvement of central neuronal axis can be detected earlier.

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“…27 Goldsher et al observed bilateral symmetrical prolongation of all peak latencies and prolongation of III-I, V-I and V-III interpeak latency differences in diabetics and more so in those with peripheral neuropathy. 28 Sharma et al observed prolongation of wave III, IV and V latencies and also I-III and I-V inter-peak latencies in diabetics. 20 The mean value of inter-aural latency difference of wave V (ILDV) was 0.0792 m. sec (0.09).…”

Section: Discussionmentioning

confidence: 99%

“…Chiappa et al reported the changes in absolute latency values with changing stimulus rate. 28 They particularly studied that effect on wave V latency. They observed that the latency of wave V was increased when the stimulus rate was changed from 10 to 80 clicks per sec.…”

Section: Discussionmentioning

confidence: 99%

A study of brainstem auditory evoked responses in normal human subjects and normal variations as a function of stimulus and subject characteristics

et al. 2016

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Background: Brainstem auditory evoked responses (BAERs) are electrophysiological investigations have widespread clinical utility in neurology, audiology, neonatology and anesthesiology. BAER responses exhibit a normal variability due to various non-pathologic factors and age is one of the variables suggested to have considerable influence on normal BAE responses. Aging changes in the auditory system may significantly influence the interpretation of the auditory brainstem responses in comparison with younger adults. The present study was undertaken to study the different parameters of brainstem evoked responses in normal subjects and their variations with changing stimulus and subject characteristics among average Indian people. Methods: The test was conducted on 50 neuro-audiologically normal subjects (age-group of 5-60 years) selected from the OPD of ENT Department. Various audio-vestibular tests they were subjected to brainstem evoked response audiometry and responses were studied regarding various parameters of ABR details. An attempt was made to find out a normal range, normative values of various parameters and their variations with respect of their stimulus intensity and subject characteristics. Results: In the present study it was observed that absolute latencies of all waves decreased with increasing stimulus intensity. The mean absolute latency values of all waves were prolonged in male than those of female subjects. The mean inter-peak latency values of I-III, III-V and I-V were also prolonged in male. Effects of change in stimulus rate on absolute latencies of all waves were observed. There were increases in absolute latencies of all waves with increasing stimulus rate. Conclusions: Increased stimulus intensity caused decrease in latency values of all values. Wave V showed lesser degree of variation than the other components. Increase in stimulus rate caused increase in latency of all waves. Wave V showed lesser degree of variation than the other components. BERA can be performed with a wide range of stimulus variations. But what was clear in conclusion was that 60dB SL was the suitable intensity level. Also a wide variety of stimulus rate can be used in combination with either of the stimulus polarity. So any combination of stimulus intensity, rate and polarity may be used for clinical application of BERA. But essence is that there should be a prior adjustment of parameter norms according to subject and stimulus characteristics.

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Auditory Brainstem Evoked Potentials in Insulin-dependent Diabetics with and without Peripheral Neuropathy

Cited by 45 publications

References 12 publications

Are there any disturbances in vestibular organ of children and young adults with Type I diabetes?

Are there any disturbances in vestibular organ of children and young adults with Type I diabetes?

Evaluation of auditory evoked response among type-II diabetic individuals in central India

A study of brainstem auditory evoked responses in normal human subjects and normal variations as a function of stimulus and subject characteristics

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