Audiovisual integration of speech is disturbed in schizophrenia: An fMRI study

Szycik, Gregor R.; Münte, Thomas F.; Dillo, Wolfgang; Mohammadi, Bahram; Samii, Amir; Emrich, Hinderk M.; Dietrich, D.E.

doi:10.1016/j.schres.2009.03.003

Cited by 75 publications

(56 citation statements)

References 62 publications

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“…Alternatively, it may be hypothesized that the simultaneous mediation of visual and auditory symptoms stemmed from the disinhibition of a higher cortical centre involved with the integration of information from various sensory modalities. This hypothesis would be in line with the impaired cortical inhibition hypothesis of schizophrenia [43,44]. …”

Section: Discussionsupporting

confidence: 70%

Treatment of Alice in Wonderland Syndrome and Verbal Auditory Hallucinations Using Repetitive Transcranial Magnetic Stimulation: A Case Report with fMRI Findings

et al. 2011

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Background: Alice in Wonderland syndrome (AIWS) is a rare cluster of CNS symptoms characterized by visual distortions (i.e. metamorphopsias), body image distortions, time distortions, and déjà experiences. Verbal auditory hallucinations (VAHs) are the most prevalent type of hallucination in adults with or without a history of psychiatric illness. Here, we report the case of a woman with AIWS, long-lasting VAHs, and various additional perceptual and mood symptoms. Methods: Semi-structured interviews were used to assess symptoms, and functional MRI (fMRI) was employed to localize cerebral activity during self-reported VAHs. Treatment consisted of repetitive transcranial magnetic stimulation (rTMS) at a frequency of 1 Hz at T3P3, overlying Brodmann’s area 40. Results: Activation during VAHs was observed bilaterally in the basal ganglia, the primary auditory cortex, the association auditory cortex, the temporal poles, and the anterior cingulated gyrus. The left and right inferior frontal gyri (Broca’s area and its contralateral homologue) were involved, along with the dorsolateral prefrontal cortex. Interestingly, synchronized activation was observed in the primary visual cortex (areas V1 and V2), and the bilateral dorsal visual cortex. The higher visual association cortex also showed significant, but less prominent, activation. During the second week of rTMS treatment, not only the VAHs, but also the other sensory deceptions/distortions and mood symptoms showed complete remission. The patient remained free of any symptoms during a 4-month follow-up phase. After 8 months, when many of the original symptoms had returned, a second treatment phase with rTMS was again followed by complete remission. Conclusions: This case indicates that VAHs and metamorphopsias in AIWS are associated with synchronized activation in both auditory and visual cortices. It also indicates that local rTMS treatment may have global therapeutic effects, suggesting an effect on multiple brain regions in a distributed network. Although a placebo effect cannot be ruled out, this case warrants further investigation of the effects of rTMS treatment in AIWS.

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Section: Discussionsupporting

confidence: 70%

Treatment of Alice in Wonderland Syndrome and Verbal Auditory Hallucinations Using Repetitive Transcranial Magnetic Stimulation: A Case Report with fMRI Findings

et al. 2011

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“…Additionally, audiovisual integration seems to be affected in several psychiatric disorders. While analyses of task performance and fMRI data have shown abnormalities of audiovisual integration in schizophrenia [16,45], on the whole, neurophysiological studies of audiovisual integration in psychiatric patients are very few. As far as we know, only 1 EEG study has reported deficits of multisensory interaction for N100 in schizophrenia, and even so, the laterality of N100 deficits was unclear [46].…”

Section: Discussionmentioning

confidence: 99%

Early Integration Processing between Faces and Vowel Sounds in Human Brain: An MEG Investigation

et al. 2015

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Objective: Unconscious fast integration of face and voice information is a crucial brain function necessary for communicating effectively with others. Here, we investigated for evidence of rapid face-voice integration in the auditory cortex. Methods: Magnetic fields (P50m and N100m) evoked by visual stimuli (V), auditory stimuli (A) and audiovisual stimuli (VA), i.e. by face, vowel and simultaneous vowel-face stimuli, were recorded in 22 healthy subjects. Magnetoencephalographic data from 28 channels around bilateral auditory cortices were analyzed. Results: In both hemispheres, AV - V showed significantly larger P50m amplitudes than A. Additionally, compared with A, the N100m amplitudes and dipole moments of AV - V were significantly smaller in the left hemisphere, but not in the right hemisphere. Conclusions: Differential changes in P50m (bilateral) and N100m (left hemisphere) that occur when V (faces) are associated with A (vowel sounds) indicate that AV (face-voice) integration occurs in early processing, likely enabling us to communicate effectively in our lives.

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“…However, very little is known about the lateralisation of cross-modal face/voice integration. Szycik et al (2009) report that participants with schizophrenia show an inverted pattern of activation in a variety of right hemisphere locations when compared with controls on a face/voice integration paradigm. Although several researchers have investigated cross-modal integration of face and voice information, to my knowledge none have focused explicitly on lateralisation.…”

Section: Cross Modal Integration and Pragmaticsmentioning

confidence: 96%

What's left to learn about right hemisphere damage and pragmatic impairment?

Weed

2011

Aphasiology

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Background:The nature and causes of pragmatic impairments following right hemisphere damage (RHD) continue to pose a challenge to researchers and clinicians. It is widely accepted that impairment in pragmatic and para-linguistic aspects of language can result from unilateral damage to the right hemisphere (RH), but it still uncertain exactly what the RH's special contributions to these areas of language and communication is. Advancing our understanding of the RH's role in pragmatics and communication will require a theoretical framework for pragmatics that is suited to the clinical environment. Aims: I first sketch several theoretical approaches to pragmatics, and suggest that Perkins' (2007) emergentist approach to pragmatics is the best suited to describing and explaining communication difficulties in a clinical setting. I then consider some of the implications of adopting the emergentist approach for research on pragmatic impairment in RHD by describing three relatively unexplored areas of research in the domain of RHD and pragmatics: application of conversation analysis techniques, investigation of the contribution of perceptual impairments to pragmatic impairment, and the comparison of pragmatic impairment across clinical groups. Main Contribution: I propose that the emergentist approach to pragmatics provides a useful framework for investigating issues of pragmatic impairment in RHD and other clinical groups, and show how adopting this approach naturally leads to research in three relatively unexplored areas. Conclusions: I argue that pursuing these lines of investigation will help move forward research in RHD, pragmatic impairment, and the general role of the right hemisphere in pragmatics.

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Audiovisual integration of speech is disturbed in schizophrenia: An fMRI study

Cited by 75 publications

References 62 publications

Treatment of Alice in Wonderland Syndrome and Verbal Auditory Hallucinations Using Repetitive Transcranial Magnetic Stimulation: A Case Report with fMRI Findings

Treatment of Alice in Wonderland Syndrome and Verbal Auditory Hallucinations Using Repetitive Transcranial Magnetic Stimulation: A Case Report with fMRI Findings

Early Integration Processing between Faces and Vowel Sounds in Human Brain: An MEG Investigation

What's left to learn about right hemisphere damage and pragmatic impairment?

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