Audiovestibular Disorders after COVID-19 Vaccine: Is There an Association?

Pisani, Davide; Gioacchini, Federico Maria; Viola, Pasquale; Scarpa, Alfonso; Astorina, Alessia; Re, Massimo; Marcianò, Gianmarco; Manti, Francesco; Anzivino, Roberta; Chiarella, Giuseppe

doi:10.3390/audiolres12030024

Cited by 22 publications

(25 citation statements)

References 61 publications

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“…Vaccines can cause local or generalized side effects and monitoring for adverse events should continue for years. Otolaryngologic adverse event after COVID-19 vaccination were observed, including several cases of sudden sensorineural hearing loss reported in the Centers for Disease Control and Prevention (CDC) Vaccine Adverse Events Reporting System (VAERS) in the United States [ 7 ]. Several cases of SSHL after vaccination have been reported, including after influenza, tetanus, diphtheria, meningococcus, and rabies vaccination.…”

Section: Resultsmentioning

confidence: 99%

Sudden Sensorineural Hearing Loss after Third Dose Booster of COVID-19 Vaccine Administration

et al. 2022

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Coronavirus disease 2019 (COVID-19) was declared a pandemic due to its rapid spread worldwide, and its vaccination campaign is considered one of the most historic public hygiene measures in modern medicine. Sudden sensorineural hearing loss (SSHL) is a common emergency that affects patient’s quality of life and requires rapid treatment with steroids. The etiology could be viral or vascular even though in most cases it remains unknown (idiopathic SSHL). During the SARS-CoV-2 vaccination campaign, several rare but serious adverse events have been reported including thrombosis with thrombocytopenia syndrome, myocarditis, and Guillain-Barré Syndrome. ENT adverse events after vaccination were reported too, including cases of sudden sensorineural hearing loss (SSHL), vestibular neuronitis and audio vestibular disorders (such as tinnitus, dizziness, and vertigo). For the first time here, we reported two cases of SSHL after third administration of COVID-19 mRNA vaccine. Even if there is not clear evidence of an association between SSHL and vaccination, adverse effects should be kept in mind since viral infection could be the etiology of SSHL.

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Section: Resultsmentioning

confidence: 99%

Sudden Sensorineural Hearing Loss after Third Dose Booster of COVID-19 Vaccine Administration

et al. 2022

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“…Previously, it has been hypothesised that cross-reactivity between the COVID-19 vaccine and host immune cells may contribute to the development of audiovestibular disorders, including vestibular neuronitis. 17 Molecular mimicry between anti-spike COVID-19 antibodies, developed after COVID-19 vaccination, and ear antigens, may explain potential cross-reactivity reactions underlying adverse events. 17 However, this case does not provide any evidence of a causal link between COVID-19 vaccination and vestibular neuronitis, and neither does any existing literature.…”

Section: Discussionmentioning

confidence: 99%

“… 17 Molecular mimicry between anti-spike COVID-19 antibodies, developed after COVID-19 vaccination, and ear antigens, may explain potential cross-reactivity reactions underlying adverse events. 17 However, this case does not provide any evidence of a causal link between COVID-19 vaccination and vestibular neuronitis, and neither does any existing literature.…”

Section: Discussionmentioning

confidence: 99%

“…Given the above evidence, we hypothesise that vestibular neuronitis may be an immune-mediated complication of COVID-19 vaccination. Previously, it has been hypothesised that cross-reactivity between the COVID-19 vaccine and host immune cells may contribute to the development of audiovestibular disorders, including vestibular neuronitis 17. Molecular mimicry between anti-spike COVID-19 antibodies, developed after COVID-19 vaccination, and ear antigens, may explain potential cross-reactivity reactions underlying adverse events 17.…”

Section: Discussionmentioning

confidence: 99%

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Vestibular neuronitis after COVID-19 vaccination

2022

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A woman in her 50s presented with acute vertigo and vomiting within 72 hours of receiving the Pfizer-BioNTech COVID-19 vaccine. The only neurological deficit was an impaired vestibulo-ocular reflex with horizontal nystagmus. The patient was subsequently diagnosed with vestibular neuronitis. She was managed symptomatically with prochlorperazine and betahistine, and underwent vestibular rehabilitation for 6 weeks. She made a full recovery and experienced no further symptoms. She received the second dose of the vaccine without complications.This case demonstrates a temporal association between COVID-19 vaccination and vestibular neuronitis. Neurological adverse events are rare but recognised side effects of COVID-19 vaccines and healthcare professionals should be aware of them. This ensures timely management of patients with such presentations. Treatment should be the same as for non-vaccine-associated vestibular neuronitis. The nature of the relationship between COVID-19 vaccination and vestibular neuronitis remains unclear and patients therefore require investigations to exclude other recognised causes of vestibular neuronitis.

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“…It is usually present early after infection. Vestibular system affection presented as an attack of sudden onset and is often within the first week 22 . Vertigo and other types of dizziness can arise from a variety of reasons without necessarily affecting the vestibular system 23 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Otorhinolaryngology Manifestations in COVID-19 Patients

Dahab¹,

Refaat

2022

The Egyptian Journal of Hospital Medicine

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Background: As COVID19 is a pandemic disease with a variety of symptoms. It was a must to study these symptoms focusing on ENT symptoms both during the illness and post recovery.Objective: This study aimed to evaluate the prevalence of otolaryngological manifestations in COVID-19 patients. Methods: A non-random cross sectional observational study included 18 patients had COVID-19. They underwent otorhinolaryngology examination. Subjective methods were used for smell and taste and audiovestibular evaluation. PTA was performed in all frequencies to determine the type and level of hearing impairment.VNG was done to detect vestibular insults if present. Results: The sample collected showed that 14 (77.7%) patients felt dizzy. Regarding smell affection, 11(61.1%) patients had smell affection of varying degrees. Sore throat and dysphagia were reported in 55.5% of patients. Dysphonia was in 6 (33.3%). Also, generalized symptoms were present in 13 (72.3%). Tinnitus only was present in 7 patients (38.9%) with 57.2% of them had normal hearing level, while the rest (42.8%) had hearing loss. As regards PTA findings, hearing impairment was bilateral in 16.66%, unilateral in 22.2% and normal hearing was noted in 61% of cases. VNG revealed central affection in 2 patients (11.1%) only. Conclusion: Audiovestibular system can be affected by SARS-COV-2 resulting in sudden sensorineural hearing loss (SSNHL) and dizziness. No systematic research was done, so the real prevalence of COVID-19 related SSNHL and dizziness around the world is unknown. Further research needs to be done.

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Audiovestibular Disorders after COVID-19 Vaccine: Is There an Association?

Cited by 22 publications

References 61 publications

Sudden Sensorineural Hearing Loss after Third Dose Booster of COVID-19 Vaccine Administration

Sudden Sensorineural Hearing Loss after Third Dose Booster of COVID-19 Vaccine Administration

Vestibular neuronitis after COVID-19 vaccination

Prevalence of Otorhinolaryngology Manifestations in COVID-19 Patients

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