Audiometric and Tympanometric Monitoring of a Disease Affecting Nerve-Muscle Transmission

Neff, Palmer A.; Morioka, Wilfred T.; Sample, Pamela A.; Cantrell, Robert W.

doi:10.3109/00206098009072670

Cited by 5 publications

(2 citation statements)

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“…The depressing effects of MG on the middle ear (ME) reflexes have been reported by a number of authors (Johns etai, 1979;Nefietal., 1980;Laurian <»/a/., 1983) and it has been suggested that the measurement of middle ear (ME) reflexes befoTe and after treatment with an anticholinesterase may be used to diagnose MG (Neff etal, 1980). Negative ME pressures have been noted in MG patients by several authors (Neff et al, 1980;Morioka etal., 1976) but a retrospective study of the otolaryngological presentation of 175 MG patients by Carpenter et al (1979) did not include any cases of Eustachian tube dysfunction. Carpenter et al (1979) did however find that the palatopharyngeal muscles were commonly involved in MG.…”

Section: Discussionmentioning

confidence: 86%

Middle ear effusions and myasthenia gravis

O'Reilly¹

1988

J. Laryngol. Otol.

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Section: Discussionmentioning

confidence: 86%

Middle ear effusions and myasthenia gravis

O'Reilly¹

1988

J. Laryngol. Otol.

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“…Toth et al 7 report that acoustic reflex threshold and decay measures in patients with myasthenia gravis were improved when a cholinesterase inhibitor (pyridostigmine) was administered. Morioka et al 8,9 report the use of acoustic reflexes to monitor the improvement in status of myasthenia gravis patients who were receiving treatment. Ruth et al 10,11 induced muscle weakness in otherwise-normal subjects by administering d-tubocurarine and, as anticipated, acoustic reflex thresholds and growth functions were altered after it was administered.…”

Section: Acoustic Reflexesmentioning

confidence: 99%

Effects of Medications on Physiological Measures of Auditory Function

Cevette

Glattke

2003

Semin Hear

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Physiologic measures that range from evaluation of the status of the middle ear to myogenic potentials linked to vestibular stimulation are important supplements to behavioral measures of hearing. All of these measures are influenced by medications that may be used to treat symptoms or otherwise help to manage patients who present with multiple handicaps. Some of the interactions occur because of the medication's direct influence on the auditory system, whereas others stem from general depressant effects on the central nervous system. In general, responses obtained from the periphery tend to be vulnerable to cochleotoxic or vestibulotoxic agents that may influence the response before they produce a measurable hearing loss. In contrast, endogenous responses are influenced markedly by level of sedation or sleep state. The clinician employing physiologic measures must be aware of the patient's medication history to interpret properly the outcomes of physiological tests.Learning Outcomes: Upon completion of this article, the reader will (1) understand the basic mechanisms of cochleotoxic and vestibulotoxic effects associated with medications, (2) be familiar with the effects of medications on measures of middle ear function, and (3) appreciate that medications may create apparently conflicting results of physiological measures of auditory system function.

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The Effect of Drugs and Systemic Disease on the Acoustic Reflex

Mangham¹

1984

The Acoustic Reflex

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Audiometric and Tympanometric Monitoring of a Disease Affecting Nerve-Muscle Transmission

Cited by 5 publications

References 1 publication

Middle ear effusions and myasthenia gravis

Middle ear effusions and myasthenia gravis

Effects of Medications on Physiological Measures of Auditory Function

The Effect of Drugs and Systemic Disease on the Acoustic Reflex

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