Audiological findings in elderly patients with chronic renal failure

Antonelli, A.; Bonfioli, Francesca; Garrubba, V.; Ghisellini, M.; Lamoretti, M. P.; Nicolai, Piero; Camerini, Corrado; Maiorca, R

doi:10.3109/00016489109127256

Cited by 40 publications

(51 citation statements)

References 35 publications

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“…Antonelli et al [1] reported that ABR wave latency was correlated to albumen and calcium levels. In addition, Pratt et al [8] reported changes in absolute and interpeak latency that were correlated to Ca ++ ion changes prior to and following hemodialysis.…”

Section: Pre-vs Post-hemodialysismentioning

confidence: 99%

“…[3] Studies using ABR as an index of auditory function among patients with end stage CRF showed evidence of various degrees of auditory dysfunction. Antonelli et al [1] compared pure tone thresholds and ABR wave latencies and interpeak latency differences of patients with end stage CRF undergoing hemodialysis to a control group of gender-and age-matched subjects with normal hearing, and to a second control group matched additionally by degree of hearing loss. They reported that pure tone hearing loss as well as wave I latency in the end stage CRF group was correlated with age and negatively correlated with serum albumin level.…”

Section: Introductionmentioning

confidence: 99%

“…The end stage CRF pathophysiology and biochemical dysfunction appear to cause auditory pathway damage, both at the sensory organ and neuronal levels. Antonelli et al [1] presented a detailed review of possible causes of hearing loss in patients with end stage CRF; they stipulated that even with strict control for confounding variables, there remains evidence of sensorineural hearing loss. Thodi et al [2] reviewed published research exploring hearing in end stage CRF and concluded that auditory function is affected by end stage CRF in various degrees in all reported studies, with findings of damage across the auditory pathway.…”

Section: Introductionmentioning

confidence: 99%

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Auditory Brainstem Responses in Patients under Treatment of Hemodialysis

Aspris

Thodi²,

Balatsouras

et al. 2008

Renal Failure

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This study evaluated the effects of end stage chronic renal failure (CRF) on auditory function and changes in auditory function following a single session of hemodialysis. The experimental group included 31 patients with end-stage renal failure on chronic hemodialysis. The control group consisted of 31 healthy volunteers. The patients were examined prior to and following a session of hemodialysis. Measurements included pure tone audiometry, tympanometry and acoustic reflex measurements, auditory brainstem responses (ABR), and blood now chemistry parameters. Controls underwent the same test battery, with the exception of biochemical and hematological assessment. Prior to hemodialysis sessions, all ABR latencies except interpeak latency I-III were significantly prolonged in the experimental group. A comparison between controls and the experimental group following hemodialysis indicated that wave V absolute latency and interpeak latencies III-V and I-V were significantly prolonged in the slow repetition rate paradigm. In the fast repetition rate, absolute latencies of waves I and V and III-V interpeak latencies were prolonged in the experimental group. Comparison of ABR recordings prior to and following hemodialysis showed overall significant difference between the measures. Post hoc analysis showed a significant improvement in wave I and V latencies in the slow repetition rate and wave V latency in the fast repetition rate. This study showed that neural conduction along the auditory pathway is delayed in patients with end stage CRF as compared to healthy subjects. Dialysis sessions improve overall neural auditory function. However, patients with end stage CRF show delayed conduction even after a session of hemodialysis.

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Section: Pre-vs Post-hemodialysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Auditory Brainstem Responses in Patients under Treatment of Hemodialysis

Aspris

Thodi²,

Balatsouras

et al. 2008

Renal Failure

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“…Antonelli et al [35] found that patients with CRF had a significantly subclinical dysfunction of the VIII nerve caused by axonal uremic neuropathy. ADMA was found to contribute to the development of neuropathy, as lowering its level leads to an improvement in different nerve functions.…”

Section: Discussionmentioning

confidence: 99%

Relation between Asymmetric Dimethylarginine (ADMA) and Hearing Loss in Patients with Renal Impairment

2008

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“…Worsening of hearing capacity has been attributed to vascular changes in the inner ear due to hyperlipidemia, ototoxic treatment, or recurrence of renal disease. 6 Sensorineural hearing impairment prevalence in pediatric transplant group was higher than in the chronic renal failure group (47% against 29%) in Mancini's study, and they found a significant correlation with the administration of ototoxic drugs after transplant (eg, aminoglycosides and furosemide). 7 Sensorineural hearing impairment prevalence was 62% in our patient group, and it was high when compared with the general population of children.…”

Section: Decibels Hertzmentioning

confidence: 99%

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Gülleroğlu

Baskın²,

Aydın³

et al. 2015

Exp Clin Transplant

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Objectives: Renal transplant provides a long-term survival. Hearing impairment is a major factor in subjective health status. Status of hearing and the cause of hearing impairment in the pediatric renal transplant group have not been evaluated. Here, we studied to evaluate hearing status in pediatric renal transplant patients and to determine the factors that cause hearing impairment. Materials and Methods: Twenty-seven pediatric renal transplant recipients were investigated. All patients underwent audiologic assessment by means of pure-tone audiometry. The factors on hearing impairment were performed. Results: Sensorineural hearing impairment was found in 17 patients. There was marked hearing impairment for the higher frequencies between 4000 and 8000 Hz. Sudden hearing loss developed in 2 patients, 1 of them had tinnitus. Decrease of speech understanding was found in 8 patients. The cyclosporine level was significantly high in patients with hearing impairment compared with group without hearing impairment. Cyclosporine levels also were found to be statistically significantly high when compared with the group with decrease of speech understanding and the group without decrease of speech understanding. Similar relations cannot be found between tacrolimus levels and hearing impairment and speech understanding. Conclusions: Sensorineural hearing impairment prevalence was high in pediatric renal transplant recipients when compared with the general population of children. Cyclosporine may be responsible for causing hearing impairment after renal transplant. We suggest that this effect is a dose-dependent toxicity.

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Audiological findings in elderly patients with chronic renal failure

Cited by 40 publications

References 35 publications

Auditory Brainstem Responses in Patients under Treatment of Hemodialysis

Auditory Brainstem Responses in Patients under Treatment of Hemodialysis

Relation between Asymmetric Dimethylarginine (ADMA) and Hearing Loss in Patients with Renal Impairment

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