Audiological and Surgical Outcomes of Pediatric Cochlear Implantation in Mondini’s Dysplasia: Our Experience

Kumari, Abha; Arumugam, Senthil Vadivu; Malik, Virender; Goyal, Sunil; Kameswaran, Mohan

doi:10.5152/iao.2020.8983

Cited by 8 publications

(9 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multichannel cochlear implantation (CI) in MD patients was first performed by Silverstein and colleagues [ 18 ]. This procedure helped restore hearing to close-to-normal levels in multiple MD cohorts worldwide [ 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Cochlear Implantation: The Volumetric Measurement of Vestibular Aqueduct and Gusher Prediction

Alahmadi

Abdelsamad²,

Almuhawas

et al. 2023

JPM

View full text Add to dashboard Cite

This study aimed to validate the role of 3D segmentation in measuring the volume of the vestibular aqueduct (VAD), and the inner ear, and to study the correlation between VAD volume and VAD linear measurements at the midpoint and operculum. The correlation with other cochlear metrics was also studied. We retrospectively recruited 21 children (42 ears) diagnosed with Mondini dysplasia (MD) plus enlarged vestibular aqueduct (EVA) from 2009 to 2021 and who underwent cochlear implantation (CI). Patients’ sociodemographic data were collected, and linear cochlear metrics were measured using Otoplan. Vestibular aqueduct width and vestibular aqueduct and inner ear volumes were measured by two independent neuro-otologists using 3D segmentation software (version 4.11.20210226) and high-resolution CT. We also conducted a regression analysis to determine the association between these variables and CT VAD and inner ear volumes. Among the 33 cochlear implanted ears, 13 ears had a gusher (39.4%). Regarding CT inner ear volume, we found that gender, age, A-value, and VAD at the operculum were statistically significant (p-Value = 0.003, <0.001, 0.031, and 0.027, respectively) by regression analysis. Moreover, we found that Age, H value, VAD at the midpoint, and VAD at the operculum were significant predictors of CT VAD volume (p-Value < 0.04). Finally, gender (OR: 0.092; 95%CI: 0.009–0.982; p-Value = 0.048) and VAD at the midpoint (OR: 0.106; 95%CI: 0.015–0.735; p-Value = 0.023) were significant predictors of gusher risk. Patients’ gusher risk was significantly differentiated by gender and VAD width at the midpoint.

show abstract

Section: Introductionmentioning

confidence: 99%

Cochlear Implantation: The Volumetric Measurement of Vestibular Aqueduct and Gusher Prediction

Alahmadi

Abdelsamad²,

Almuhawas

et al. 2023

JPM

View full text Add to dashboard Cite

show abstract

“…Of these, 108 were excluded (Fig. 1), and ultimately 55 studies were included for analysis (Dahm et al 1995; Tucci et al 1995; Slattery & Luxford 1995; Munro et al 1996; Aschendorff et al 1997; Hoffman et al 1997; Woolley et al 1998; Au & Gibson 1999; Bent et al 1999; Harker et al 1999; Temple et al 1999; Fahy et al 2001; Miyamoto et al 2002; Daneshi et al 2003; Arnoldner et al 2004; Buchman et al 2004; Mylanus et al 2004; Loundon et al 2005; Papsin 2005; Sennaroglu et al 2006; Wootten et al 2006; Vassoler et al 2008; Lee et al 2010; Dettman et al 2011; Kontorinis et al 2011; Kuthubutheen et al 2012; Lai et al 2012; Broomfield et al 2013; Ko et al 2013; Tzifa & Hanvey 2013; Eftekharian & Amizadeh 2014; Bille et al 2015; Busi et al 2015; Jeong & Kim 2015; Pradhananga et al 2015; Pritchett et al 2015; Bianchin et al 2016; Manzoor et al 2016; Mey et al 2016; van Nierop et al 2016; Bostic et al 2017; Clarós et al 2017; Grover et al 2017; Isaiah et al 2017; Melo et al 2017; Roh et al 2017; Kim et al 2018; Hall et al 2019; Mikkelsen et al 2019; Shi et al 2019; Hura et al 2020; Ozkan et al 2020; Kumari et al 2021; Patterson et al 2021; Skrivan et al 2021). In total, 1572 children with cochlear implants were included, 698 were male and 539 female.…”

Section: Resultsmentioning

confidence: 99%

“…Preimplantation and postimplantation scores. A, Preimplantation, and postimplantation Capacity of Auditive Performance (CAP) score levels between the six studies (Fahy et al 2001; Danehsi et al 2003; Ko et al 2013; Tzifa et al 2013; Busi et al 2015; Kumari et al 2021) reporting CAP score. B, Preimplantation, and postimplantation Speech Intelligibility Rating (SIR) score levels between the five studies (Danehsi et al 2003; Ko et al 2013; Tzifa et al 2013; Grover et al 2017; Kumari et al 2021) reporting SIR score.…”

Section: Resultsmentioning

confidence: 99%

Cochlear Implantation in Children with Enlarged Vestibular Aqueduct: A Systematic Review of Surgical Implications and Outcomes

Hansen

Rasmussen²,

Cayé‐Thomasen

et al. 2022

Ear &Amp; Hearing

View full text Add to dashboard Cite

Objectives: This study investigated age at implantation, improvement in hearing and speech perception outcomes, as well as surgical complications in pediatric cochlear implant recipients with Pendred Syndrome (PS) or non-syndromic enlarged vestibular aqueduct (NSEVA). Design:A systematic review of the literature between 1984 and 2021 was performed. Two independent reviewers performed abstract and full-text screening using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The inclusion criteria were: English language, cochlear implant, age at implantation available, age <18 years, PS, Mondini malformation, and enlarged vestibular aqueduct. Full-text analysis was completed using the National Institute of Health assessment tool for case series and case-control studies. Studies were also graded according to the Oxford Centre for Evidence-Based Medicine grading system. Results:In total, 198 studies were identified and screened, and 55 studies were included for analysis. Audiological outcomes were available in 46 studies, and the four-frequency pure-tone audiogram average improved by 60 to 78 dB HL due to cochlear implantation. Auditory performance and speech intelligibility scores increased by 44%. The overall average implantation age was 60 months. The implantation age was 21 months lower in the studies where individuals were implanted after the year 2000 compared with those implanted before the year 2000. Perilymph gusher/ oozing was the most common surgical incident reported, occurring in 187 of 1572 implantations. Conclusions:In children with PS/NSEVA, cochlear implantation improves pure-tone average by 60 to 78 dB HL and capacity of auditory performance/speech intelligibility by 44%. The implantation age for these children has decreased during the last two decades but is still somewhat higher than reported for unselected pediatric cochlear implantation. Perilymph gusher/oozing is the most common surgical complication.

show abstract

“…Since then, several studies have demonstrated that CI in patients with Mondini dysplasia has a clear benefit in both children and adults, and can be safely performed (5,6,8,(12)(13)(14). Furthermore, a few studies have reported that postoperative auditory skills of young children with Mondini dysplasia developed rapidly over a period of 3 years after CI, in a similar manner to that in children with normal inner ear anatomy (5,6,15). However, there are still few reports about the development of auditory performance after CI over a long-term follow-up period, and an analysis of the anatomical features of Mondini dysplasia is especially lacking.…”

Section: Introductionmentioning

confidence: 99%

“…Mondini dysplasia is one of the most commonly diagnosed IEMs and was first reported by Carlo Mondini in 1791 based on an autopsy of an 8-year-old boy with congenital SNHL (5)(6)(7)(8). It occurs because of the arrest of embryonic development at the seventh gestational week of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Anatomical Features of Children With Mondini Dysplasia: Influence on Cochlear Implantation Performance

Joo,

Lee,

Lee

et al. 2023

Otol Neurotol

View full text Add to dashboard Cite

Objective: To analyze the long-term auditory performance after cochlear implantation (CI) and identify anatomical features of Mondini dysplasia associated with post-CI outcomes. Study Design: Retrospective study. Setting: Tertiary care academic center. Patients: We enrolled 49 ears with Mondini dysplasia who underwent CI with more than 7 years of follow-up and age at CIand sex-matched control group with radiologically normal inner ears. Main Outcomes and Measures: The development of auditory skills after CI was evaluated using word recognition scores (WRSs). The anatomical features were measured based on temporal bone computed tomography and magnetic resonance imaging, involving the width of the bony cochlear nerve canal (BCNC), cochlear basal turn, enlarged vestibular aqueduct, cochlear height, and diameter of the cochlear nerve (CN). Results: CI in ears with Mondini dysplasia showed comparable benefits and improvement of auditory performance to controls during the 7 years of follow-up. In Mondini dysplasia, four (8.2%) ears showed narrow BCNC (<1.4 mm) with poorer WRS (58 ± 17%) than those with normal-sized BCNC, which had WRS (79 ± 10%) comparable to that of the control group (77 ± 14%). In Mondini dysplasia, the maximum (r = 0.513, p < 0.001) and minimum (r = 0.328, p = 0.021) CN diameters had positive correlations with post-CI WRS. The maximum CN diameter (β = 48.347, p < 0.001) and BCNC width (β = 12.411, p = 0.041) were significant factors that influence the post-CI WRS in multiple regression analysis. Conclusions: Preoperative anatomical evaluation, especially BCNC status and CN integrity, may serve as predictive markers for post-CI performance.

show abstract

Audiological and Surgical Outcomes of Pediatric Cochlear Implantation in Mondini’s Dysplasia: Our Experience

Cited by 8 publications

References 16 publications

Cochlear Implantation: The Volumetric Measurement of Vestibular Aqueduct and Gusher Prediction

Cochlear Implantation: The Volumetric Measurement of Vestibular Aqueduct and Gusher Prediction

Cochlear Implantation in Children with Enlarged Vestibular Aqueduct: A Systematic Review of Surgical Implications and Outcomes

Anatomical Features of Children With Mondini Dysplasia: Influence on Cochlear Implantation Performance

Contact Info

Product

Resources

About