Audiologic characterization using clinical physiological measures: Normative data from macaque monkeys

Stahl, Amy N.; Mondul, Jane A.; Alek, Katy A.; Hackett, Troy A.; Ramachandran, Ramnarayan

doi:10.1016/j.heares.2022.108568

Cited by 2 publications

(1 citation statement)

References 113 publications

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“…Each MF was repeated 30 times, resulting in blocks containing ∼300-420 trials. Experiments were performed after confirming normal hearing status through extensive audiometric and physiological characterization (ABRs, DPOAEs, otoscopy, and tympanometry), ensuring that all measures were within the range of normative values as reported in our previous work (Burton et al, 2019; Hauser et al, 2018; Stahl et al, 2022; Valero et al, 2017). Figure 1B shows how monkeys Is and Da learned to discriminate amplitude modulation frequency (MF) at various MFs in about ten sessions.…”

Section: Methodsmentioning

confidence: 99%

Psychometric and subcortical neurometric measures of temporal discrimination in rhesus macaques

Mackey

Hauser

Schoenhaut

et al. 2022

Preprint

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Temporal envelope fluctuations are abundant in nature and are critical for perception of complex sounds. While psychophysical sinusoidal amplitude modulation (SAM) processing studies have characterized the perception of SAM, and neurophysiological studies report a subcortical transformation from temporal to rate-based code, no studies have characterized this transformation in unanesthetized animals or in nonhuman primates. To address this, we recorded single-unit responses and compared derived neurometric measures in the cochlear nucleus (CN) and inferior colliculus (IC) to psychometric measures of modulation frequency (MF) discrimination in macaques. IC and CN neurons often exhibited tuned responses to SAM in their rate and spike-timing. Neurometric thresholds spanned a large range (2-200 Hz Δ MF). The lowest 40% of IC thresholds were less than or equal to psychometric thresholds, regardless of which code was used, while CN thresholds were greater than psychometric thresholds. Discrimination at 10-20 Hz could be explained by indiscriminately pooling 30 units in either structure, while discrimination at higher MFs was best explained by more selective pooling. This suggests that pooled brainstem activity was sufficient for AM discrimination. Psychometric and neurometric thresholds decreased as a function of stimulus duration, but IC and CN thresholds were greater and more variable than behavior at durations less than 500 ms. This slower subcortical temporal integration compared to behavior was consistent with a drift diffusion model which reproduced individual differences in performance and can constrain future neurophysiological studies of temporal integration. These measures provide an account of AM perception at the neurophysiological, computational, and behavioral levels.

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Section: Methodsmentioning

confidence: 99%

Psychometric and subcortical neurometric measures of temporal discrimination in rhesus macaques

Mackey

Hauser

Schoenhaut

et al. 2022

Preprint

Self Cite

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Hierarchical differences in the encoding of amplitude modulation in the subcortical auditory system of awake nonhuman primates

Mackey,

Hauser,

Schoenhaut

et al. 2024

Journal of Neurophysiology

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Sinusoidal amplitude modulation (SAM) is a key feature of complex sounds. While psychophysical studies have characterized SAM perception, and neurophysiological studies in anesthetized animals report a transformation from the cochlear nucleus' (CN; brainstem) temporal code to the inferior colliculus' (IC; midbrain's) rate code, none have used awake animals or nonhuman primates to compare CN and IC's coding strategies to modulation-frequency perception. To address this, we recorded single-unit responses and compared derived neurometric measures in the CN and IC to psychometric measures of modulation frequency (MF) discrimination in macaques. IC and CN neurons often exhibited tuned responses to SAM in rate and spike-timing measures of modulation coding. Neurometric thresholds spanned a large range (2-200 Hz DMF). The lowest 40% of IC thresholds were less than or equal to psychometric thresholds, regardless of which code was used, while CN thresholds were greater than psychometric thresholds. Discrimination at 10-20 Hz could be explained by indiscriminately pooling 30 units in either structure, while discrimination at higher MFs was best explained by more selective pooling. This suggests that pooled CN activity was sufficient for AM discrimination. Psychometric and neurometric thresholds decreased as stimulus duration increased, but IC and CN thresholds were higher and more variable than behavior at short durations. This slower subcortical temporal integration compared to behavior was consistent with a drift diffusion model which reproduced individual differences in performance and can constrain future neurophysiological studies of temporal integration. These measures provide an account of AM perception at the neurophysiological, computational, and behavioral levels.

show abstract

Audiologic characterization using clinical physiological measures: Normative data from macaque monkeys

Cited by 2 publications

References 113 publications

Psychometric and subcortical neurometric measures of temporal discrimination in rhesus macaques

Psychometric and subcortical neurometric measures of temporal discrimination in rhesus macaques

Hierarchical differences in the encoding of amplitude modulation in the subcortical auditory system of awake nonhuman primates

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