Audiogenic seizures in the developmentally primed Long-Evans rat

Ross, Karen C.; Coleman, James R.

doi:10.1002/(sici)1098-2302(199905)34:2<303::aid-dev6>3.0.co;2-x

Cited by 18 publications

(8 citation statements)

References 50 publications

(70 reference statements)

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“…Audiogenic seizures are only rarely seen in humans, but are well-documented in mammals in which the auditory system matures postnatally (Ross and Coleman 1999). Genetically susceptible rodents with hearing loss, or rodents primed by sound exposure, sound deprivation, or kanamycin exposure (Pierson and Swann 1988) during postnatal development show altered excitability levels in the auditory system such that they are more susceptible to audiogenic seizures (Ross and Coleman 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Genetically susceptible rodents with hearing loss, or rodents primed by sound exposure, sound deprivation, or kanamycin exposure (Pierson and Swann 1988) during postnatal development show altered excitability levels in the auditory system such that they are more susceptible to audiogenic seizures (Ross and Coleman 1999). Although audiogenic seizures do not present clinically in humans (Fisher 1989), many of the same substrates that are involved in audiogenic seizures are also involved in generalized human seizures (Ross and Coleman 2000).…”

Section: Discussionmentioning

confidence: 99%

“…These seizures present differently from forebrain induced seizures which start with facial and forelimb tremors and progress to a clonic or clonic-tonic state (Racine 1972). Interestingly, the Long-Evans rats used in our studies are generally less susceptible to seizures than other rat strains, but can be made more susceptible to audiogenic seizures by priming with damaging noise during the critical period of cochlear development (Ross and Coleman 1999; 2000). …”

Section: Introductionmentioning

confidence: 99%

“…We used a classic audiogenic seizure testing paradigm in which the rats were exposed to a brief high intensity noise (Ross and Coleman 1999) and the incidence, severity and latency to onset of seizure behaviors were recorded.…”

Section: Introductionmentioning

confidence: 99%

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Developmental PCB exposure increases susceptibility to audiogenic seizures in adulthood

et al. 2015

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Developmental exposure to polychlorinated biphenyls (PCBs) causes auditory deficits. Thus, we recently conducted a study to investigate if developmental PCB exposure would exacerbate noise-induced hearing loss in adulthood. Unexpectedly, some PCB-exposed rats exhibited seizure-like behaviors when exposed to loud noise. Therefore, we conducted the current experiment to determine if adult rats perinatally exposed to PCBs are more susceptible to audiogenic seizures when tested in a standard audiogenic seizure paradigm. Adult male and female rats exposed to PCBs during gestation and lactation (0, 1, 3 or 6 mg/kg/day) and previously tested in the noise-induced hearing loss study were presented with a 100dB noise stimulus. If they did not exhibit clonus in response to the 100dB noise, they were exposed to a 105dB stimulus 24-48 hours later. This was followed by an 110dB stimulus 24-48 hours later if they did not exhibit clonus at 105 dB. Female and male rats exposed to either 3 or 6 mg/kg PCBs exhibited a significantly higher incidence of audiogenic seizures, shorter latency to onset of seizures, and greater severity of seizures compared to controls. Thyroxine measured in littermates at weaning was significantly lower in all PCB groups compared to controls, suggesting a potential mechanism for the increased incidence of audiogenic seizures. This is the first study to show that developmental PCB exposure increases the susceptibility to audiogenic seizures in adulthood.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Developmental PCB exposure increases susceptibility to audiogenic seizures in adulthood

et al. 2015

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“…Second, rats, in contrast to mice, have been selected for the predisposition to audiogenic seizure fits, and several seizure-prone strains have been obtained [8][9][10]. These are, for instance, genetic epilepsy prone strains GEPR3 and GEPR9 obtained from the outbred strain Sprague-Dowley [9] in the University of Arizona (United States) in the late 1950s, strains WAR and KM (Krushinsky-Molodkina) selected from outbred Wistar rats [10,11], and the well-known outbred strain Long-Evans [12].…”

Section: Introductionmentioning

confidence: 99%

Genetic Analysis of the Predisposition to Audiogenic Seizure Fits in Krushinsky-Molodkina Rat Strain

Poletaeva

et al. 2005

Russ J Genet

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The expression of audiogenic seizure fits has been studied in F 1 hybrids between audiogenic seizure-prone Krushinsky-Molodkina rat strain and Wistar rats not prone to audiogenic seizures, as well as in two backcross generations. Only 10% of F 1 hybrids exhibit audiogenic seizure fits, whereas the frequency of this character in two generations of their backcrosses with Krushinsky-Molodkina rats is about 50%. A digenic model with incomplete penetrance has been put forward to explain the control of audiogenic seizure fits. This model fits the data obtained: the theoretically expected distributions of the character in offsprings of different crosses do not differ significantly from those observed in experiments. The model explains why the distribution of the character is the same in the first and second backcross offsprings. GENERAL GENETICS

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