Audiogenic kindling stimulates aberrant neurogenesis, synaptopodin expression, and mossy fiber sprouting in the hippocampus of rats genetically prone to audiogenic seizures

The NOP antagonist BTRX-246040 increases stress resilience in mice without affecting adult neurogenesis in the hippocampus

“…Of note, such rapid changes in differentiation process are possible and already reported in the literature in response to different stimuli (i.e. 1 day of mifepristone administration, 3 days of treatment with the thyroid hormone T3, 4 days of audiogenic seizures, and 2 days of wheel running (Gremmelspacher et al, 2017;Hu et al, 2012;Kapoor et al, 2012;Kulikov et al, 2021). Further studies are needed to understand the cellular mechanism involved in this rapid neurogenesis alteration and its biological significance.…”