Aucubin protects against myocardial ischemia-reperfusion injury by regulating STAT3/NF-κB/HMGB-1 pathway

Liu, Yanwu; Cheng, Xian; Qi, Bingcai; Wang, Yuchao; Zheng, Yue; Liang, Xiaoyu; Chang, Yun; Ning, Meng; Gao, Wenqing; Li, Tong

doi:10.1016/j.ijcard.2024.131800

International Journal of Cardiology

2024

DOI: 10.1016/j.ijcard.2024.131800

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Aucubin protects against myocardial ischemia-reperfusion injury by regulating STAT3/NF-κB/HMGB-1 pathway

Yanwu Liu,

Xian Cheng,

Bingcai Qi

et al.

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2024

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Cited by 3 publications

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Aucubin protects against myocardial ischemia-reperfusion injury via activation of the AKT/STAT3 pathway

Wang,

Xu,

et al. 2024

International Journal of Cardiology

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Aucubin protects against myocardial ischemia-reperfusion injury via activation of the AKT/STAT3 pathway

Wang,

Xu,

et al. 2024

International Journal of Cardiology

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Role of gasotransmitters in necroptosis

Cao,

Wang,

Chu

et al. 2024

Experimental Cell Research

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Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway

Long,

Yang,

Zhou

2024

Open Medicine

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Background Sepsis triggers myocardial injury and dysfunction, leading to a high mortality rate in patients. Cardiomyocyte apoptosis plays a positive regulatory role in septic myocardial injury and dysfunction. However, the mechanism is unclear. Methods Bioinformatics analysis was used to identify differentially expressed genes in septic mice heart and validate key genes and pathways. The correlation of protein–protein and protein–pathway was analyzed. Sequentially, the cecal ligament and puncture (CLP) was used to induce septic mice, followed by Serpine1 inhibitor treatment. Finally, the regulatory relationship of Yes-associated protein1 (YAP1), Serpine1, and caspase-3 was verified in LPS-exposed mouse cardiomyocytes. Results Bioinformatic analysis found that Serpine1 expression is decreased in septic mice heart tissue and closely related to the HIPPO signaling pathway, while YAP1 is negatively correlated with apoptosis. In vivo, CLP induced a reduction of survival rate, cardiac dysfunction, and an increase in Serpine1 and Cleaved Caspase-3 expression, which could be reversed by a Serpine1 inhibitor. In vitro, LPS induced the mouse cardiomyocytes apoptosis, which could be reversed by Serpine1 inhibitor. Silencing YAP1 and Serpine1 reversed the LPS-induced increase in Serpine1 and Cleaved Caspase-3 expression, but silencing Serpine1 did not affect the LPS-induced YAP1 expression. Conclusion Sepsis induced mouse cardiomyocytes apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway.

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Aucubin protects against myocardial ischemia-reperfusion injury by regulating STAT3/NF-κB/HMGB-1 pathway

Cited by 3 publications

References 40 publications

Aucubin protects against myocardial ischemia-reperfusion injury via activation of the AKT/STAT3 pathway

Aucubin protects against myocardial ischemia-reperfusion injury via activation of the AKT/STAT3 pathway

Role of gasotransmitters in necroptosis

Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway

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