Au NPs decorated holey g-C3N4 as a dual-mode sensing platform of SERS and SALDI-MS for selective discrimination of L-cysteine

Pei, Jingxuan; Sun, Yibo; Yu, Xingwen; Tian, Zhenfei; Zhang, Shuting; Wei, Songbo; Zhao, Yanfang; Boukherroub, Rabah

doi:10.1016/j.jcis.2022.06.176

Cited by 28 publications

(7 citation statements)

References 58 publications

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“…The main constituent in the structures of these nanosized matrices can be a variety of particles, such as gold, silver, iron oxide, or titanium dioxide. − The main structural differences between metal nanoparticles and carbon-based ones are the high variability in the crystal structures of the metal-based nanoparticles compared to the more homogeneous structure of the carbon-based nanoparticles. Metal-based nanoparticles have been combined with other compounds to improve their physicochemical properties, increasing their efficiency as MALDI matrices. − Silica particles, for example, have been coated with gold nanoparticles and used as a matrix for MALDI imaging of a series of low molecular weight compounds, such as amino acids, peptides, and small carbohydrates in a variety of plant and animal tissues . A higher number of analytes were detected with lower matrix-related interferences, lower LODs, and better reproducibility of the results compared to the conventional matrix, CHCA .…”

Section: Carbon-based Nanoparticles In Comparison With Other Nanopart...mentioning

confidence: 99%

Carbon-Based Nanoparticles and Their Surface-Modified Counterparts as MALDI Matrices

Khajavinia

El‐Aneed

2023

Anal. Chem.

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Section: Carbon-based Nanoparticles In Comparison With Other Nanopart...mentioning

confidence: 99%

Carbon-Based Nanoparticles and Their Surface-Modified Counterparts as MALDI Matrices

Khajavinia

El‐Aneed

2023

Anal. Chem.

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“…More importantly, this approach has achieved the discrimination of cysteine enantiomers in serum sample, indicating its potential application value for identifying bio-enantiomer target (Figure 9C). [178] More interestingly, Song et al used SERS in conjunction with SPR technique for SPR/SERS dual-modality sensing miRNA-652 based on catalytic hairpin assembly between AuNPs probes. [179] To realize real-time diagnosis of cancer, SERS is frequently employed to combine with other imaging techniques, such as dark-field scattering and photoacoustic imaging (PAI).…”

Section: Hybrid Biosensors Of Sers and Other Modesmentioning

confidence: 99%

“…Reprinted from Ref. [178] with permission from Elsevier. (D) The ratiometric SERS and dark-field scattering dual-modal sensing system based on Au@COF/MPBA for monitoring intracellular H 2 O 2 .…”

Section: Hybrid Biosensors Of Sers and Other Modesmentioning

confidence: 99%

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Recent Research Progress of Surface‐Enhanced Raman Scattering Dominated Analysis Strategies in Early Diagnosis of Diseases

Chen

Zheng

Tang

et al. 2023

Chemistry An Asian Journal

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Timely and powerful diagnostic means can achieve better therapeutic effects, reduce disease torment, and improve survival rate. As a powerful non‐invasive spectroscopy technology, surface‐enhanced Raman scattering (SERS) have testified to be a great potential candidate for extensive early clinical disease diagnosis. In recent years, the introduction of SERS label, combined with other analysis modes or artificial intelligence, and the emergence of miniaturized devices have made SERS technology more advantageous in early diagnosis of diseases. This review focuses on the research progress of SERS dominated analytical strategies in the field of early disease diagnosis in the past five years. The main content includes the application of label‐free SERS detection; the construction of label SERS methodologies for various disease markers; SERS dominated multimode early disease diagnosis strategies; integration of SERS and artificial intelligence; portable Raman equipment and SERS imaging; and opportunities and trends for SERS diagnostic technology in the future.

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“…Therefore, measurement of L-Cys, TP, and its derivatives levels is important for clinical diagnosis and environmental restoration. Many optical as well as nonoptical analytical techniques have been used so far to detect thiols, such as chemiluminescence, voltammetry, fluorescence, photoelectrochemical methods, time-resolved photoluminescence spectroscopy, high-performance liquid chromatography (HPLC), electrochemical methods, and a handful of surface-enhanced Raman spectroscopy (SERS)-based methods. − However, most of these techniques suffer from individual drawbacks such as interference from other analytes, time-consuming operation, complex substrate preparation, and difficult synthesis of fluorescent probes. Additionally, the choice of analytical method to quantify the small molecule L-Cys and TPs should be based on the lowest limit of quantification (LOQ) because the lowest LOQ would allow for detection and quantification in the smallest amount of analytical sample, minimizing the volume of the sample collection.…”

Section: Introductionmentioning

confidence: 99%

Ag–Au–Cu Trimetallic Alloy Microflower: A Highly Sensitive SERS Substrate for Detection of Low Raman Scattering Cross-Section Thiols

Kaja,

Nag

2023

Langmuir

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Trimetallic Ag−Au−Cu alloy microflowers (MFs) with various surface compositions were synthesized on a glass coverslip and used as efficient surface-enhanced Raman spectroscopy (SERS) substrates for highly sensitive label-free detection of smaller Raman scattering crosssection molecules, namely, L-cysteine and toxic thiophenols. MFs of different compositions were synthesized via appropriate mixing of metal− alkyl ammonium halide precursors followed by a single-step thermolysis at 350 °C. While the Ag percentage was kept constant at 90% for all the substrates, the composition of Au and Cu was varied between 1 and 9% sequentially. The synthesized MFs were thoroughly characterized by using field emission scanning electron microscopy (FE-SEM), wide-angle X-ray scattering, X-ray photoelectron spectroscopy (XPS), and X-ray fluorescence techniques. FE-SEM studies revealed that the MFs were present throughout the substrate, and the average size varied from 20 to 40 μm. XPS studies showed that the top surface of the alloy substrates was rich in either Au or Cu atoms, while Ag remained underneath. The performance of the trimetallic MFs as SERS substrates was evaluated using Rhodamine 6G as a probe molecule, which showed that the MFs with Ag−Au−Cu compositions 90−7−3 and 90−3−7 were found to be the best and of equal SERS efficiency. The SERS enhancement factor (EF) of both these MFs was found to be the same, approximately 9 × 10 7 , when calculated using 1,2,3benzatriazole as the probe molecule. Between the two, the trimetallic substrate with a higher Au percentage (Ag−Au−Cu as 90−7− 3) was used for the sensitive SERS-based detection of thiols to exploit the strong Au−S binding interaction. By virtue of the high EF of the substrate, the inherently low Raman scattering cross-sections of the probe molecules were greatly enhanced in SERS mode. The 'limit of quantification (LOQ)' values were found to be 1 nM for aliphatic L-Cysteine and 1−0.1 pM for aromatic thiols using the trimetallic SERS sensor.

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Au NPs decorated holey g-C3N4 as a dual-mode sensing platform of SERS and SALDI-MS for selective discrimination of L-cysteine

Cited by 28 publications

References 58 publications

Carbon-Based Nanoparticles and Their Surface-Modified Counterparts as MALDI Matrices

Carbon-Based Nanoparticles and Their Surface-Modified Counterparts as MALDI Matrices

Recent Research Progress of Surface‐Enhanced Raman Scattering Dominated Analysis Strategies in Early Diagnosis of Diseases

Ag–Au–Cu Trimetallic Alloy Microflower: A Highly Sensitive SERS Substrate for Detection of Low Raman Scattering Cross-Section Thiols

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