Au nanoparticles/ZnO nanorods as SALDI-MS substrate for on-plate enrichment and detection of glutathione in real samples

Carbon-Based Nanoparticles and Their Surface-Modified Counterparts as MALDI Matrices

“…Shortly after the development of MALDI ionization, several researchers tested the possibility of using different nanoparticles as alternative matrices to conventional ones. − Carbon-based nanoparticles, silicon-based nanoparticles, metallic nanoparticles, and their combinations (i.e., hybrid matrices) are among the main groups of nanosized matrices. − In this paper, we reviewed in detail carbon-based matrices and their derivatives, and here we briefly compare other nanoparticles utilized as MALDI matrices to carbon-based ones.…”

Use of metal nanoparticles for preconcentration and analysis of biological thiols

“…The size distribution of these NPs, as prepared, was quite wide, nevertheless, as they have magnetic properties, no centrifugation was needed for their efficient separation from the samples. Various biological thiols (DTT, GSH, thiabendazole, and sulfamethizole) could be analyzed using MALDI-MS. Another interesting account on preconcentration and analysis of GSH in real biological samples is the use of ZnO nanorods grafted with AuNPs using SALDI-MS [177]. The ZnO nanorods coated with AuNPs served as direct SALDI-MS substrate allowing for selective reaction with thiol containing compounds (Au-S bond), whereas other compounds could be rinsed with deionized water.…”

Continuous synthesis of BaFe2O4 and BaFe12O19 nanoparticles in a droplet microreactor for efficient detection of antihistamine drugs in oral fluid using surface-assisted laser desorption/ionization mass spectrometry

“…35 Owing to these advantages, this method has been used in various research areas such as environmental, 35,36 forensic, 37 medical, 38 and others. 39,40 SALDI-MS has rapidly evolved in recent years, providing insights into many challenges faced in modern research. However, the design and selection of appropriate SALDI-MS substrates can be a time-consuming process.…”

“…35 Owing to these advantages, this method has been used in various research areas such as environmental, 35,36 forensic, 37 medical, 38 and others. 39,40…”