Au nanoclusters/porous silica particles nanocomposites as fluorescence enhanced sensors for sensing and mapping of copper(II) in cells

Wang, Shengxu; Yang, Boyu; Zhang, Zhuqing; Xu, Xiaowei; Li, Hui; Cheng, Guiru; Yang, Zekai; Du, Hao; Yang, Yizhou; Yang, Xudong

doi:10.1088/1361-6528/ab3d1c

Cited by 9 publications

(4 citation statements)

References 46 publications

(57 reference statements)

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“…As among the most produced engineered nanomaterials, silica nanoparticles (NPs) were extensively used in various traditional industrial manufacturing products including plastics, rubbers, ceramics, pigments, coatings, and cosmetics. − Recently, due to their high surface area and better biodegradability, silica NPs were applied in many biomedical fields, for example, diagnosis, − bone regeneration scaffolds, , drug delivery carriers, , and cancer therapies. − With increasing industrial production and applications, the exposure of silica NPs gradually increases via dietary intake, skin contact, respiration, and systematic administration . Recently, studies demonstrated that the exposure of silica NPs could cause significant in vitro , and in vivo toxicities. , …”

Section: Introductionmentioning

confidence: 99%

Surface Modification of Stöber Silica Nanoparticles with Controlled Moiety Densities Determines Their Cytotoxicity Profiles in Macrophages

Li¹,

Cheng²,

Xue

et al. 2019

Langmuir

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Physicochemical properties of nanomaterials play important roles in determining their toxicological profiles during nano-biointeraction. Among them, surface modification is one of the most effective manners to tune the cytotoxicity induced by nanomaterials. However, currently, there is no consistency in surface modification including moiety types and quantities considering the conflicting toxicological profiles of particles across different studies. In this study, in order to systematically investigate how the moiety density affects cytotoxicity of NPs, we chose three different types of functional groups, that is, −NH2, −COOH, and −PEG, and further controlled their densities on modified Stöber silica nanoparticles (NPs). We demonstrated that densities of functional groups could significantly affect the cytotoxicities of Stöber silica NPs. Regardless of the types of functional groups, high grafting densities could ameliorate the cytotoxicities induced by Stöber silica NPs in macrophages, for example, J774A.1 and N9 cells. When equal amounts of functional groups were present, the cell viability increased in the order of −COOH < −NH2 < −PEG. Furthermore, it was shown that surface modification could significantly affect the quantities of the surface silanol, which is the determining factor that affects their cytotoxicity. These results show that it is critical to control the surface moiety both quantitatively and qualitatively, which can tune the interaction outcomes at the nano-bio interface. The results found in this article provide useful guidance to adjust nanomaterial cytotoxicity for safer biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Surface Modification of Stöber Silica Nanoparticles with Controlled Moiety Densities Determines Their Cytotoxicity Profiles in Macrophages

Li¹,

Cheng²,

Xue

et al. 2019

Langmuir

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“…From this works, it can be seen that the addition of different polymeric materials resulted in different assembly processes at the same power. The ultrasound field enhanced the emulsification of non-ionic polymers [ 65 , 66 , 67 ] but also strengthens the binding between Au and Ag clusters.…”

Section: Resultsmentioning

confidence: 99%

Metal Cluster Triggered-Assembling Heterogeneous Au-Ag Nanoclusters with Highly Loading Performance and Biocompatible Capability

Yang

et al. 2022

IJMS

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In this work, we firstly report the preparation of heterogeneously assembled structures Au-Ag nanoclusters (NCs) as good drug carriers with high loading performance and biocompatible capability. As glutathione-protected Au and Ag clusters self-assembled into porous Au-Ag NCs, the size value is about 1.358 (±0.05) nm. The morphology characterization revealed that the diameter of Au-Ag NCs is approximately 120 nm, as well as the corresponding potential ability in loading performance of the metal cluster triggered-assembling process. Compared with individual components, the stability and loading performance of heterogeneous Au-Ag NCs were improved and exhibit that the relative biocompatibility was enhanced. The exact information about this is that cell viability was approximately to 98% when cells were incubated with 100 µg mL−1 particle solution for 3 days. The drug release of Adriamycin from Au-Ag NCs was carried out in PBS at pH = 7.4 and 5.8, respectively. By simulating in vivo and tumor microenvironment, the release efficiency could reach over 65% at pH = 5.8 but less than 30% at pH = 7.2. Using an ultrasound field as external environment can accelerate the assembling process while metal clusters triggered assembling Au-Ag NCs. The size and morphology of the assembled Au-Ag NCs can be controlled by using different power parameters (8 W, 13 W, 18 W) under ambient atmosphere. Overall, a novel approach is exhibited, which conveys assembling work for metal clusters triggers into heterogeneous structures with porous characteristic. Its existing properties such as water-solubility, stability, low toxicity and capsulation can be considered as dependable agents in various biomedical applications and drug carriers in immunotherapies.

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“…The relative fluorescence intensity of I 565 (the excitation/emission slit width was set at 5 nm, separately) of the CPDs and the concentration of N 2 H 4 ·H 2 O were also observed. 35 The fluorescence spectra of N 2 H 4 ·H 2 O, H 2 O, CH 3 OH, CHCl 3 , C 4 H 8 O 2 , C 6 H 15 NO 3 , CH 3 NO, CH 3 COCH 3 , C 6 H 14 , C 3 H 8 O, C 2 H 5 OH, AA to CPDs were tested under the same conditions. Compared with other interfering solvents, the CPDs had better selectivity for N 2 H 4 ·H 2 O.…”

Section: Methodsmentioning

confidence: 99%

Fe-doped carbonized polymer dot-based fluorescent sensor with “turn-on” property for hydrazine hydrate detection

Miao

et al. 2022

Dalton Trans.

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Au nanoclusters/porous silica particles nanocomposites as fluorescence enhanced sensors for sensing and mapping of copper(II) in cells

Cited by 9 publications

References 46 publications

Surface Modification of Stöber Silica Nanoparticles with Controlled Moiety Densities Determines Their Cytotoxicity Profiles in Macrophages

Surface Modification of Stöber Silica Nanoparticles with Controlled Moiety Densities Determines Their Cytotoxicity Profiles in Macrophages

Metal Cluster Triggered-Assembling Heterogeneous Au-Ag Nanoclusters with Highly Loading Performance and Biocompatible Capability

Fe-doped carbonized polymer dot-based fluorescent sensor with “turn-on” property for hydrazine hydrate detection

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