Au-catalyzed neighboring hydroxymethyl group directed cycloaddition of alkyne with diazadienes: Synthesis of polysubstituted pyrroles

Synthesis of Imidazo[1,2-a]pyridine-Fused 1,3-Benzodiazepine Derivatives with Anticancer Activity via a One-Pot Cascade GBB-3CR/Pd(II)-Catalyzed Azide-Isocyanide Coupling/Cyclization Process

“… The imidazo­[1,2- a ]­pyridines and 1,3-benzodiazepines are two important nitrogen-containing heterocyclic scaffolds commonly used in the discovery of biologically active compounds. Many synthetic approaches have been reported in the literature due to their significant properties and important applications . However, there are no literature precedents for the preparation of imidazo­[1,2- a ]­pyridine-fused 1,3-benzodiazepine frameworks, and such a kind of active splicing skeleton may have the potential to be used in various small-molecule drug discovery studies.…”

Direct Access to 3-Thioether-Substituted Dihydrofuro[2,3-b]benzofurans via Tandem Reactions of Sulfur Ylides and 2-Nitrobenzofurans

“…Sulfur ylides are widely used as effective one-carbon synthons. Their inherent zwitterionic properties and reactivity enable their participation in various cyclic compounds constructions . However, in most cases, the sulfide motifs in the sulfur ylides are always eliminated as a leaving group as the reaction proceeds, which leads to the low atom economy.…”

Gold self-relay catalysis enabling annulative oxygenation of propargylic alcohols with O-nucleophiles

“…12 Specifically, gold self-relay catalysis, where gold catalysts govern robust π- and σ-activation modes and drive two or more distinct elementary reactions to proceed in turn under the same reaction conditions, could extensively enhance synthetic efficiency. 13 Consequently, such catalysis demonstrates great potential in synthetic chemistry. Although several elegant gold self-relay catalysis reactions have been established, the types of these reactions are very limited.…”