Au@109Pd core-shell nanoparticle conjugated to trastuzumab for the therapy of HER2+ cancers. Studies on the applicability of 109Pd/109mAg in vivo generator in combined β−Auger electron therapy
Nasrin Abbasi Gharibkandi,
Kamil Wawrowicz,
Agnieszka Majkowska-Pilip
et al.
Abstract:Background:
In radionuclide therapy, to enhance therapeutic efficacy, an intriguing alternative is to ensure the simultaneous implementation of low- and high-LET radiation emitted from a one radionuclide. In the present study, we introduce the concept of utilizing 109Pd (T1/2=13.7 h) in the form of a 109Pd/109mAg in vivo generator. In this system, 109Pd emits beta particles of medium energy, while 109mAg releases a cascade of conversion and Auger electrons. 109Pd was utilized in the form of 15nm gold nanopart… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.