Atypical vessels as an early sign of intracardiac myxoma?

Dübel, Hans-Peter; Knebel, Fabian; Gliech, V.; Konertz, Wolfgang; Rutsch, Wolfgang; Baumann, Gert; Borges, Adrian C.

doi:10.1186/1476-7120-2-13

Cited by 7 publications

(2 citation statements)

References 11 publications

(9 reference statements)

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“…Inflammatory cells may be present throughout the lesion. The base of the lesion usually contains prominent chronic inflammatory cells (lymphocytes, plasma cells, and macrophages), areas of old and recent hemorrhage with hemosiderin-laden macrophages, and thick walled vessels, which are likely related to the solid phenotype and chronicity of the lesion [ 13 , 57 , 60 ] ( Figures 5a–c , 6a,b ). Occasionally, multinucleated tumor giant cells, blood cells, histiocytes, fibroblasts, smooth muscle cells, mucin-forming glands, ring structures (single or multiple concentric layers of myxoma cells surrounding the capillaries), artery-like vessels, superficial thrombi, calcification, chondrocytes, osteoblasts, metaplastic bone, cysts, Gamna-Gandy bodies (degenerated collagen encrusted with iron or calcium), thymic rests and foci of extramedullary hematopoiesis are also seen ( Figures 7a,b , 8a,b ).…”

Section: Cardiac Myxomasmentioning

confidence: 99%

Molecular Basis of Cardiac Myxomas

Singhal

Luk

Rao

et al. 2014

IJMS

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Cardiac tumors are rare, and of these, primary cardiac tumors are even rarer. Metastatic cardiac tumors are about 100 times more common than the primary tumors. About 90% of primary cardiac tumors are benign, and of these the most common are cardiac myxomas. Approximately 12% of primary cardiac tumors are completely asymptomatic while others present with one or more signs and symptoms of the classical triad of hemodynamic changes due to intracardiac obstruction, embolism and nonspecific constitutional symptoms. Echocardiography is highly sensitive and specific in detecting cardiac tumors. Other helpful investigations are chest X-rays, magnetic resonance imaging and computerized tomography scan. Surgical excision is the treatment of choice for primary cardiac tumors and is usually associated with a good prognosis. This review article will focus on the general features of benign cardiac tumors with an emphasis on cardiac myxomas and their molecular basis.

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Section: Cardiac Myxomasmentioning

confidence: 99%

Molecular Basis of Cardiac Myxomas

Singhal

Luk

Rao

et al. 2014

IJMS

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“…The various sources of blood supply to various myxomas reported are described in box 1 6–26The source of blood supply of some reported myxomasLeft atrial myxoma—from the right coronary artery 6–8 24Right atrial myxoma—from the right coronary artery 4 11 16 17…”

Section: Outcome and Follow-upmentioning

confidence: 99%

How does knowledge of the blood supply to an intracardiac tumour help?

Gupta¹,

Sagar²,

Ramachandran³

et al. 2019

BMJ Case Rep

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Myxoma is a common benign tumour found in the heart. On reviewing literature, we found some left atrial myxomas receive blood supply from the right coronary artery. Performing a coronary angiogram in a cardiac tumour has the following uses: (1) it shows the vascularity that can be ligated by the surgeon at operation; (2) if there is a blood supply visible, it may not be an intracardiac thrombus; (3) the coronary angiogram may detect a myxoma even before an echocardiogram does so; (4) some myxomas may bleed into the right atrium or left atrium and this may be seen on coronary angiography. We show here the neovascularity of a left atrial myxoma and its blood supply from the right coronary artery. We recommend that all routine coronary angiograms be reviewed carefully for any signs of tumour vascularity or tumour blush as this would prevent missing early myxomas. Echocardiography is the gold standard for detection of myxomas but literature has a number of intracardiac tumours that were detected only by the tumour blush. Some left atrial tumours have been treated by occluding their blood supply.The absence of a blood supply on coronary angiography could rule out a benign cardiac tumour that usually has a blood supply.

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Value of Coronary Angiography in the Cardiac Myxoma

Lee

Jung

et al. 2019

Clinical Anatomy

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Preoperative coronary angiography for cardiac myxoma not only excludes coronary artery disease but also detects the artery feeding the cardiac myxoma, which has several clinical implications. In this study, we examined cardiac myxoma cases in two tertiary hospitals using coronary angiography to identify the artery feeding the myxoma. We retrospectively reviewed 42 patients with cardiac myxoma who had undergone surgical removal between July 2008 and December 2015 in two tertiary hospitals, and recorded their baseline characteristics, echocardiographic findings, and coronary angiography. Among those 42 patients, 23 (55%) had coronary angiography before surgery and in no case was significant luminal narrowing observed. In 21 of the coronary angiograms, the artery feeding the cardiac myxoma had a vascular branch (100%), clusters of tortuous vessels with contrast medium pooling (67%), an arteriocavity fistula (33%), and a mobile feeding artery (67%). No significant relationship was found between coronary artery dominance type and the origin of the artery feeding the cardiac myxoma (P = 0.362). Identification of the artery feeding the cardiac myxoma, with a distinctive vascular appearance in coronary angiography, is important for several clinical applications such as helping to diagnose cardiac myxoma and to plan the surgical approach. Clin. Anat. 33:833–838, 2020. © 2019 Wiley Periodicals, Inc.

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Atypical vessels as an early sign of intracardiac myxoma?

Cited by 7 publications

References 11 publications

Molecular Basis of Cardiac Myxomas

Molecular Basis of Cardiac Myxomas

How does knowledge of the blood supply to an intracardiac tumour help?

Value of Coronary Angiography in the Cardiac Myxoma

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