Atypical vesicles and membranes with monolayer and multilayer structures formed by graft copolymers with diblock side-chains: nonlamellar structures and curvature-enhanced permeability

Abstract

Graft copolymers with diblock side-chains Am(-graft-B3Ay)n in a selective solvent have been reported to self-assemble into vesicles, but the structure is expected to differ distinctly from lipid bilayers. Surprisingly, the...

Flow-Driven Translocation of Strung Micelles Formed by Core–Shell Bottle-Brush Copolymers and the Accompanying Morphological Transformation through a Nanochannel

“…Core–shell bottle-brush copolymers with diblock side chains have emerged as a focal point in the study of polymer aggregates. − These copolymers can generate well-defined individual nanoparticles such as spherical and cylinder micelles, worm-like micelles, , and monolayer and multilayer vesicles . Additionally, it has been demonstrated that these copolymers can assemble strung micelles with increased backbone rigidity. − Our previous study revealed that stable single or strung micelles could be obtained separately by adjusting the architectural parameters of core–shell bottle-brush copolymers .…”

Multicompartment Micro- and Nanoparticles Using Supramolecular Assembly of Core–Shell Bottlebrush Polymers

“…The self-assembly of this functional polymer allows creation of compartmentalized macromolecules and assembly of them into supramolecular multicompartmentalized structures. Driven by the intermolecular interactions between hydrophilic/hydrophobic blocks on the pendent chains, the aggregation of bottlebrush polymers generates a wide range of multifunctional structures from nanoparticles exhibiting well defined linear compartments to microparticles and percolated polymer networks presenting granular inner structures …”

“…Driven by the intermolecular interactions between hydrophilic/hydrophobic blocks on the pendent chains, the aggregation of bottlebrush polymers generates a wide range of multifunctional structures from nanoparticles exhibiting well defined linear compartments to microparticles and percolated polymer networks presenting granular inner structures. 17 Core−shell bottlebrush polymers with pendent chains of poly(D,L-lactic acid)-block-poly(2-methacryloyloxyethyl phosphorylcholine) (PLA-b-PMPC) amphiphilic "AB" diblock copolymers grafted on a poly(2-hydroxyethyl methacrylate (HEMA)-co-methyl methacrylate (MMA) backbone were produced via the "grafting from" approach (Scheme 1). The core−shell bottlebrush polymer was obtained in five synthetic steps combining ATRP, ROP, and postmodification techniques.…”