Atypical variant of trigeminal trophic syndrome successfully treated with pregabalin: a case report series

Abstract

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Trigeminal trophic syndrome: an important simulator of discoid cutaneous lupus erythematosus – a case series

“…Carbamazepine, gabapentin, pregabalin, amitriptyline, diazepam and chlorpromazine have been used, with varying results. 1,3,6 We obtained excellent results in treating patient 1. Patient 4 took amitriptyline for a while, with some decrease in manipulation.…”

“…granulomatosis with polyangiitis and Horton’s arteritis). 2,3,5,6 Patient 1 had no known neurological abnormality, and he refused to undergo magnetic resonance imaging. We speculate whether his past local surgery and radiotherapy might have damaged trigeminal innervation.…”

“…11 Treatment of TTS should be centred on behavioural modification intended to reduce self-induced trauma. 5,6 Patients must become aware of the role of self-manipulation and assiduously avoid it. Occlusive dressings and protective devices to cover the wound and the patient’s hands are of little value.…”

Trigeminal trophic syndrome in a pediatric patient with diffuse intrinsic pontine glioma

“…Pharmacological intervention usually involves gabapentin or carbamazepine to diminish trigeminal paresthesia 3 . Alternatives also cited in the literature include tiagabine, oxcarbazepine, and pregabalin 11,12 . Topical tacrolimus may provide benefit, 13,14 though our patient did not find this helpful.…”

“…A significant association exists between neurotic excoriation and childhood traumatic events, and about 80% of these patients were found to have at least one Axis I psychiatric disorder 18 . No studies extensively cover the role of excoriation disorder or psychiatric disease in TTS, though one case series highlighted the development of clinical depression secondary to TTS lesions 12 . Due to the general association between mood disorders and skin excoriation, the increased sertraline dose and additional amitriptyline may have indirectly diminished skin picking by addressing the patient's underlying mood disorder and anxiety.…”