Atypical triggers in trigeminal neuralgia: the role of A-delta sensory afferents in food and weather triggers

Koh, Wenjun; Lim, Huili; Chen, Xuanxuan

doi:10.3344/kjp.2021.34.1.66

Cited by 3 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, trigeminal neuralgia is often triggered by gentle touching of the face and talking [26]. There are few reports of trigeminal neuralgia being triggered by low temperatures [27]. Since Aδ and C fibers, which express Na V 1.7, are activated by noxious cold stimuli [28], cold sensation and the E44Q mutation might have a synergistic effect in trigeminal neuralgia.…”

Section: Discussionmentioning

confidence: 99%

E44Q mutation in NaV1.7 in a patient with infantile paroxysmal knee pain: electrophysiological analysis of voltage-dependent sodium current

Takahashi

Ohba

Okamoto

et al. 2021

Heliyon

View full text Add to dashboard Cite

Gain-of-function mutations in voltage-gated sodium channels (Na V 1.7, Na V 1.8, and Na V 1.9) are known causes of inherited pain disorders. Identification and functional assessment of new Na V 1.7 mutations could help elucidate the phenotypic spectrum of Na V 1.7 channelopathies. We identified a novel Na V 1.7 mutation (E44Q in exon 2) that substitutes a glutamic acid residue for glutamine in the cytoplasmic N-terminus of Na V 1.7 in a patient with paroxysmal pain attacks during childhood and his family who experienced similar pain episodes. To study the sodium channel's function, we performed electrophysiological recordings. Voltage-clamp recordings revealed that the mutation increased the amplitude of the non-inactivating component of the sodium current, which might facilitate channel opening. These data demonstrate that E44Q is a gain-of-function mutation in Na V 1.7, which is consistent with our patient's pain phenotype.

show abstract

Section: Discussionmentioning

confidence: 99%

E44Q mutation in NaV1.7 in a patient with infantile paroxysmal knee pain: electrophysiological analysis of voltage-dependent sodium current

Takahashi

Ohba

Okamoto

et al. 2021

Heliyon

View full text Add to dashboard Cite

show abstract

Role of voltage-gated sodium channels in axonal signal propagation of trigeminal ganglion neurons after infraorbital nerve entrapment

Mulpuri

Yamamoto

Nishimura

et al. 2022

Neurobiology of Pain

View full text Add to dashboard Cite

The efficacy of acupuncture for trigeminal neuralgia: an overview of systematic reviews

He,

Li,

Xiao

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

BackgroundMany systematic reviews (SRs) and meta-analysis (MAs) have reported the efficacy of acupuncture treatment for primary trigeminal neuralgia (PTN), but the quality of evidence is unknown and therefore needs to be evaluated comprehensively.MethodsEight electronic databases were searched from their inception until January 5, 2024. The methodological quality, reporting quality, and risk of bias of the included SRs were assessed by the assessment of multiple systematic reviews 2 (AMSTAR-2), the Risk of Bias in Systematic Reviews (ROBIS) tool, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The quality of evidence for outcome measures was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).ResultsWe identified 13 SRs/MAs met inclusion criteria. According to the results of the AMSTAR-2, six were rated as critically low quality and seven as low quality. According to ROBIS assessment, 8 SRs/MAs were classified as low risk, and 5 SRs/MAs were found to be high risk. The PRISMA report still has some reporting deficiencies in aspects such as protocol and registration, search strategy, risk of bias, additional analyzes and funding. According to the GRADE system, no high-quality evidence was found, 1 was of moderate quality, 4 were of low quality, and 8 were of critical low quality.ConclusionBased on the evidence collected, acupuncture shows promise as a treatment for PTN patients. However, it is important to note that the included SRs/MAs generally have low methodological quality and evidence quality. Therefore, caution must be exercised when interpreting this conclusion. To enhance future research in this area, it is recommended to adequately report methodological details and adhere to guidelines for conducting SRs/MAs.Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024499280.

show abstract

Atypical triggers in trigeminal neuralgia: the role of A-delta sensory afferents in food and weather triggers

Cited by 3 publications

References 25 publications

E44Q mutation in NaV1.7 in a patient with infantile paroxysmal knee pain: electrophysiological analysis of voltage-dependent sodium current

E44Q mutation in NaV1.7 in a patient with infantile paroxysmal knee pain: electrophysiological analysis of voltage-dependent sodium current

Role of voltage-gated sodium channels in axonal signal propagation of trigeminal ganglion neurons after infraorbital nerve entrapment

The efficacy of acupuncture for trigeminal neuralgia: an overview of systematic reviews

Contact Info

Product

Resources

About