Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans

Baltaci, Oguzhan; Pedersen, M. E.; Sherry, Tessa; Handley, Ava; Snieckute, Goda; Cao, Wei; Haas, Matilda; Archer, Stuart K.; Pocock, Roger

doi:10.1016/j.isci.2022.103791

Cited by 10 publications

(12 citation statements)

References 43 publications

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“…UNC-129 represents a more atypical TGF-β signaling ligand with no known type I/II receptors and is thought to regulate the migration of motor neurons ( Colavita et al 1998 ; MacNeil et al 2009 ). A similar function in motor neuron migration has also recently been described for TIG-2 and TIG-3 ( Gumienny and Savage-Dunn 2013 ; Savage-Dunn and Padgett 2017 ; Baltaci et al 2022 ).…”

Section: Introductionsupporting

confidence: 74%

“…This includes the Ppa-unc-129 signaling ligand which shows no unc phenotype in P. pacificus and is unlikely to share the role in axon guidance described in C. elegans . Additionally, the Ppa-tig-2 pathway appears to have a role in establishing the correct body size in P. pacificus , whereas in C. elegans , it is also associated with neuronal guidance ( Baltaci et al 2022 ). However, the most striking differences between species were observed in the DAF-7 signaling network.…”

Section: Discussionmentioning

confidence: 99%

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Evolution and Diversity of TGF-β Pathways are Linked with Novel Developmental and Behavioral Traits

Roca²,

Dardiry

et al. 2022

Molecular Biology and Evolution

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Transforming growth factor β (TGF-β) signalling is essential for numerous biological functions. It is a highly conserved pathway found in all metazoans including the nematode Caenorhabditis elegans, which has also been pivotal in identifying many components. Utilising a comparative evolutionary approach, we explored TGF-β signalling in nine nematode species and revealed striking variability in TGF-β gene frequency across the lineage. Of the species analysed, gene duplications in the DAF-7 pathway appear common with the greatest disparity observed in Pristionchus pacificus. Specifically, multiple paralogues of daf-3, daf-4 and daf-7 were detected. To investigate this additional diversity, we induced mutations in 22 TGF-β components and generated corresponding double, triple and quadruple mutants revealing both conservation and diversification in function. Although, the DBL-1 pathway regulating body morphology appears highly conserved, the DAF-7 pathway exhibits functional divergence, notably in some aspects of dauer formation. Furthermore, the formation of the phenotypically plastic mouth in P. pacificus is partially influenced through TGF-β with the strongest effect in Ppa-tag-68. This appears important for numerous processes in P. pacificus but has no known function in C. elegans. Finally, we observe behavioural differences in TGF-β mutants including in chemosensation and the establishment of the P. pacificus kin-recognition signal. Thus, TGF-β signalling in nematodes represents a stochastic genetic network capable of generating novel functions through the duplication and deletion of associated genes.

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Section: Introductionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Evolution and Diversity of TGF-β Pathways are Linked with Novel Developmental and Behavioral Traits

Roca²,

Dardiry

et al. 2022

Molecular Biology and Evolution

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“…Until very recently, there were no published functions for TIG-2 or TIG-3. However, TIG-2, TIG-3 and UNC-129 were recently shown to play a role in neuronal migration ( Baltaci et al, 2022 ). In this function, they act non-redundantly through an atypical signaling pathway.…”

Section: Tig-2 Tig-3 and Unc-129mentioning

confidence: 99%

TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans

Yamamoto,

Savage-Dunn

2023

Front. Genet.

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The Transforming Growth Factor-β (TGF-β) superfamily of signaling molecules plays critical roles in development, differentiation, homeostasis, and disease. Due to the conservation of these ligands and their signaling pathways, genetic studies in invertebrate systems including the nematode Caenorhabditis elegans have been instrumental in identifying signaling mechanisms. C. elegans is also a premier organism for research in longevity and healthy aging. Here we summarize current knowledge on the roles of TGF-β signaling in aging and immunity.

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“…Growth factors, such as TGF-β ligands, are prominent guidance cues during axon development ( Table 1 ). UNC-129/TGF-β is secreted by dorsal body wall muscle and directs axon guidance through unknown non-canonical TGF-β receptors ( MacNeil et al, 2009 ; Baltaci et al, 2022 ). Notably, UNC-129 binds to the Netrin receptor UNC-5 and facilitates UNC-6/Netrin repulsive guidance by enhancing UNC-5 and UNC-40 signaling ( MacNeil et al, 2009 ).…”

Section: Genetic Control Of Axo-dendritic Developmentmentioning

confidence: 99%

The regulatory landscape of neurite development in Caenorhabditis elegans

Godini

Fallahi

Pocock

2022

Front. Mol. Neurosci.

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Neuronal communication requires precise connectivity of neurite projections (axons and dendrites). Developing neurites express cell-surface receptors that interpret extracellular cues to enable correct guidance toward, and connection with, target cells. Spatiotemporal regulation of neurite guidance molecule expression by transcription factors (TFs) is critical for nervous system development and function. Here, we review how neurite development is regulated by TFs in the Caenorhabditis elegans nervous system. By collecting publicly available transcriptome and ChIP-sequencing data, we reveal gene expression dynamics during neurite development, providing insight into transcriptional mechanisms governing construction of the nervous system architecture.

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Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans

Cited by 10 publications

References 43 publications

Evolution and Diversity of TGF-β Pathways are Linked with Novel Developmental and Behavioral Traits

Evolution and Diversity of TGF-β Pathways are Linked with Novel Developmental and Behavioral Traits

TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans

The regulatory landscape of neurite development in Caenorhabditis elegans

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