Atypical teratoid/rhabdoid tumor (ATRT) arising from the 3rd cranial nerve in infants: a clinical-radiological entity?

Oh, Christopher C.; Orr, Brent A.; Bernardi, Bruno; Garrè, Maria Luisa; Rossi, Andrea; Figà-Talamanca, Lorenzo; Robinson, Giles; Patay, Zoltán

doi:10.1007/s11060-015-1787-0

Cited by 12 publications

(12 citation statements)

References 34 publications

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“…AT/RT has a similar incidence rate in young pediatric patients as medulloblastoma and primitive neuroectodermal tumor (PNET), at approximately 2%, but it is very rare in adults (9,10). AT/RT occurs more frequently in men than in women, with a ratio of ∼2: 1 (8).…”

Section: Discussionmentioning

confidence: 99%

Atypical Teratoid/Rhabdoid Tumor Originated From the Trigeminal Nerve in a Young Male Adult: Case Report and Review of the Literature

Chen

Mei

et al. 2020

Front. Neurol.

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Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant central nervous system neoplasm predominantly found in children under the age of 3 years, and is extremely rare in adults. There is no specific clinical presentations or radiological features in reported cases of AT/RT. Diagnosis of brain AT/RT is mainly dependent on the classical pathological characteristics. We report a rare case of AT/RT arising from the trigeminal nerve and leading to progressively multiple cranial nerve palsies in a 25-year-old male patient. Microsurgical resection of the tumor has been performed and confirmed the diagnosis by postoperative pathology. To our knowledge, this is the second case of adult-onset AT/RT originating from the trigeminal nerve.

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Section: Discussionmentioning

confidence: 99%

Atypical Teratoid/Rhabdoid Tumor Originated From the Trigeminal Nerve in a Young Male Adult: Case Report and Review of the Literature

Chen

Mei

et al. 2020

Front. Neurol.

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“…In addition to the midline or lateral posterior fossa like the more common medulloblastomas (Fig 7), they can also be found in the supratentorial compartment or spine (59). While they usually manifest as intra-axial masses, there are rare case reports of extradural invasion of the overlying calvaria (60), tumors arising from the oculomotor nerve (61), and even primary diffuse cerebral leptomeningeal AT/RT with plaquelike disease (62) (Fig 8).…”

Section: Atypical Teratoid/rhabdoid Tumormentioning

confidence: 99%

Embryonal Tumors of the Central Nervous System: From the Radiologic Pathology Archives

Shih

Koeller

2018

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Embryonal tumors of the central nervous system (CNS) are highly malignant undifferentiated or poorly differentiated tumors of neuroepithelial origin and have been defined as a category in the World Health Organization (WHO) classification since the first edition of the "Blue Book" in 1979. This category has evolved over time to reflect our ever-improving understanding of tumor biology and behavior. With the most recent update in 2016, many previous histologic diagnoses incorporate molecular parameters for the first time (genetically defined entities). While medulloblastoma and atypical teratoid/rhabdoid tumor are familiar carryovers from the 2007 CNS WHO classification, there are major changes to the embryonal tumor category: for example, elimination of the term CNS primitive neuroectodermal tumor and addition of a new genetically defined entity, embryonal tumor with multilayered rosettes, C19MC-altered. The purpose of this article is to discuss both the radiologic-pathologic features of CNS embryonal tumors and the new molecularly defined types/subtypes that will become the standard classification/terminology for future diagnoses and tumor research.

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“…4 Immunohistochemical stain showed that these lesions lose the nuclear expression of INI1 (a tumor suppressor gene, usually mutated in malignant rhabdoid tumors), and are positive for Vimentin, S-100 protein and epithelial membrane antigen (EMA). 2 In our case, both INI1 (►Fig. 3d) and neu-N (a neuronal marker) were negative in the immunohistochemical stain, while it was positive for S-100 protein (present in cells derived from the neural crest), glial fibrillary acid protein (GFAP), typical of glial lesions, and Synaptophysin (representing neural/neuroendocrine tissues).…”

Section: Discussionmentioning

confidence: 51%

“…The atypical rhabdoid teratoid tumor (ARTT) is a rare embryonic tumor, defined as a distinct entity in 1996 and included in the World Health Organization (WHO) classification of central nervous system (CNS) tumors in 2000. [1][2][3] In 2016, the WHO ranked the ARTT as a CNS embryonal tumor with rhabdoid features. 4 The ARTT is a highly malignant tumor whose survival period is around 1 year.…”

Section: Introductionmentioning

confidence: 99%

Supratentorial Atypical Rhabdoid Teratoid Tumor – A Case Report

et al. 2018

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Atypical rhabdoid teratoid tumors (ARTTs) are rare embryonic tumors, usually localized in the posterior fossa and diagnosed in children under 3 years-old. The treatment includes surgical resection, radio and chemotherapy, and the prognostic is unfavorable, with an average median survival of 1 year. We present the case of a 3-year-old patient, with history of headache and vomiting, followed by absence seizures, temporal automatism, syncope accompanied by sialorrhea and sphincteric loss succeeded by a postictal period. Surgical excision was performed and the anatomopathological study confirmed ARTT. The ARTTs are embryonic tumors, a category in which medulloblastoma and primitive neuroectodermal tumors (PNETs) represent the most common central nervous system (CNS) malignancies in childhood.

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Atypical teratoid/rhabdoid tumor (ATRT) arising from the 3rd cranial nerve in infants: a clinical-radiological entity?

Cited by 12 publications

References 34 publications

Atypical Teratoid/Rhabdoid Tumor Originated From the Trigeminal Nerve in a Young Male Adult: Case Report and Review of the Literature

Atypical Teratoid/Rhabdoid Tumor Originated From the Trigeminal Nerve in a Young Male Adult: Case Report and Review of the Literature

Embryonal Tumors of the Central Nervous System: From the Radiologic Pathology Archives

Supratentorial Atypical Rhabdoid Teratoid Tumor – A Case Report

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