Atypical TDP‐43 proteinopathy clinically presenting with progressive nonfluent aphasia: A case report
Yuki Suzuki,
Tadashi Adachi,
Kentaro Yoshida
et al.
Abstract:Progressive nonfluent aphasia (PNFA) is a form of frontotemporal lobar degeneration (FTLD) caused by tau and transactive response DNA‐binding protein of 43 kDa (TDP‐43) accumulation. Here we report the autopsy findings of a 64‐year‐old right‐handed man with an atypical TDP‐43 proteinopathy who presented with difficulties with speech, verbal paraphasia, and dysphagia that progressed over the 36 months prior to his death. He did not show pyramidal tract signs until his death. At autopsy, macroscopic brain examin… Show more
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