Atypical subacute sclerosing panencephalitis: case report

Abstract

-Subacute sclerosing panencephalitis (SSPE) is a progressive inflammatory disorder of the central nervous system with both poor prognosis and high mortality. The disease has been related to a persistent and aberrant measles virus infection and no effective treatment has been available. We report a case of SSPE with atypical features including seizures at onset and a fulminant course in a 8 years-old boy who had been previously immunized against measles.KEY WORDS: subacute sclerosing panencephalitis, measles, immunization.Panencefalite esclerosante subaguda: relato de caso atípico RESUMO -Panencefalite esclerosante subaguda (PES) é uma doença inflamatória e progressiva do sistema nervoso central com prognóstico reservado e alta mortalidade. A doença tem sido relacionada com a infecção persistente e anormal pelo vírus do sarampo e não há tratamento específico disponível. Relatamos um caso de PES com características atípicas representadas por início do quadro com crises convulsivas e apresentação fulminante em menino de 8 anos previamente imunizado contra o vírus do sarampo.PALAVRAS-CHAVE: panencefalite esclerosante subaguda, sarampo, imunização.

Atypical subacute sclerosing panencephalitis presenting in a toddler with a short latency period: Evolving epidemiological trend

“…Early-onset SSPE with short onset latency is generally associated with congenital and neonatal measles infection. Zwiauer et al diagnosed a case of SSPE as early as 4 months of age after perinatally acquired measles infection [8]. It is seen that children with early age of onset of measles infection have a shorter latency period as seen with our case.…”

A Case Report of Paediatric Subacute Sclerosing Panencephalitis

“…(6)In this child, a latent period of 7-8 years was noted after which symptoms started in form of seizures initially generalised tonic-clonic followed by jerky movements associated with behavioural abnormalities.. There was difficulty in vision (8) . There was no associated fever , any other systemic complaints .There is a positive history of measles infection with unvaccinated patient.…”

Subacute Sclerosing Panencephalitis With Atypical Clinical and MRI Findings

“…Atypical features include unusual age of onset, visual loss, seizures and other focal symptoms as initial presentations, a lack of SSPE-specific EEG pattern, and atypical fast progression of disease [6]. While ophthalmological symptoms such as optic atrophy, chorioretinitis, and papilledema are commonly associated with SSPE [4][5][6][7].…”