Atypical Squamous Cells of Undetermined Significance

Sheils, Lucy A.; Wilbur, David C.

doi:10.1159/000332789

Cited by 76 publications

(5 citation statements)

References 9 publications

(15 reference statements)

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“…In contrast to other studies, which have reported atypical squamous metaplastic cells and atypical glandular cell as high‐risk subcategories, 3,4,25–28 we found no significant differences in outcome among atypical squamous cells, atypical metaplastic cells or atypical glandular cells in our study population. Subtyping of the PAP 2 category seems to provide no additional value in the Netherlands diagnostic practice.…”

Section: Discussioncontrasting

confidence: 99%

“…Most other studies provide information on CIN or worse after a single or initial BNC smear. In these studies CIN 1+ was found in 10–46% and CIN 2+ in 1.7–14% 7,8,9,12,13,20,23,24,26,29,30 . One study, focusing on atypical squamous metaplastic cells 25 even found CIN 1+ in 62% and CIN 2+ in 44%.…”

Section: Discussionmentioning

confidence: 95%

“…In these studies CIN 1+ was found in 10-46% and CIN 2+ in 1.7-14%. 7,8,9,12,13,20,23,24,26,29,30 One study, focusing on atypical squamous metaplastic cells 25 even found CIN 1+ in 62% and CIN 2+ in 44%. Carcinoma following a borderline result was reported in only a limited number of studies and in low frequencies, ranging from 0.1% to 3.8%.…”

Section: Discussionmentioning

confidence: 99%

“… determine the compliance of GPs to refer women with repeated BNC results for colposcopy; evaluate the significance of repeated BNC by determining the detection rate of CIN 1 or worse (CIN 1+: CIN 1, CIN 2, CIN 3 and carcinoma) and CIN 2 or worse (CIN 2+: CIN 2, CIN 3 and carcinoma); investigate concurrently the value of other predictors for CIN 1+ or CIN 2+ in patients with repeated BNC Pap tests including age, 8,11,23,24 cytological type of borderline abnormality, 4,25–28 concurrent infection or inflammation (among which HPV‐associated cellular changes), 27,29,30 reported clinical symptoms and prior smear history of the patient 28 …”

Section: Introductionmentioning

confidence: 99%

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Referral compliance, outcome and predictors of CIN after repeated borderline cervical smears in the Netherlands

2007

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This finding may be used for prioritizing women for colposcopy on the basis of their age. More stringent use of the diagnosis of BNC, higher thresholds for colposcopically directed biopsy and introduction of HPV triage, combined with more specific new techniques or combination of techniques such as molecular markers for P16, MIB-1 and L1 may reduce the unnecessary high referral rate and over treatment of healthy women.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Referral compliance, outcome and predictors of CIN after repeated borderline cervical smears in the Netherlands

2007

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“…Cytoplasmic processes can also be present. Immature squamous metaplasia is associated with a fine chromatin pattern and dense cytoplasmic differentiation [ 14 ]. A fine chromatin pattern along with dense cytoplasmic differentiation is a significant diagnostic feature of immature squamous metaplasia, and the presence of prominent nucleoli is highly predictive of reactive cell change ( Fig.…”

Section: High Grade Intraepithelial Squamous Lesion Mimicsmentioning

confidence: 99%

Trouble-makers in cytologic interpretation of the uterine cervix

Shin

Hong³

2023

JPTM

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The development and standardization of cytologic screening of the uterine cervix has dramatically decreased the prevalence of squamous cell carcinoma of the uterine cervix. Advances in the understanding of biology of human papillomavirus have contributed to upgrading the histologic diagnosis of the uterine cervix; however, cytologic screening that should triage those that need further management still poses several difficulties in interpretation. Cytologic features of high grade intraepithelial squamous lesion (HSIL) mimics including atrophy, immature metaplasia, and transitional metaplasia, and glandular lesion masquerades including tubal metaplasia and HSIL with glandular involvement are described with accentuation mainly on the differential points. When the cytologic features lie in a gray zone between the differentials, the most important key to the more accurate interpretation is sticking to the very basics of cytology; screening the background and cellular architecture, and then scrutinizing the nuclear and cytoplasmic details.

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Stanley F. Patten, jr., M.D., Ph.D., and atypical cells of squamous type

Wilbur

1997

Cancer

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Atypical Squamous Cells of Undetermined Significance

Cited by 76 publications

References 9 publications

Referral compliance, outcome and predictors of CIN after repeated borderline cervical smears in the Netherlands

Referral compliance, outcome and predictors of CIN after repeated borderline cervical smears in the Netherlands

Trouble-makers in cytologic interpretation of the uterine cervix

Stanley F. Patten, jr., M.D., Ph.D., and atypical cells of squamous type

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