Atypical small acinar proliferation at index prostate biopsy: rethinking the re-biopsy paradigm

Ynalvez, Leslie; Kosarek, Christopher D.; Kerr, Preston; Mahmoud, Alì Mokhtar; Eyzaguirre, Eduardo; Orihuela, Eduardo; Sonstein, Joseph; Williams, Stephen B.

doi:10.1007/s11255-017-1714-8

Cited by 9 publications

(15 citation statements)

References 31 publications

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“…Describing the characteristics of patients both with and without a repeat biopsy is important to proper interpretation of the analysis results of repeat biopsy because the implementation of a repeat biopsy should be biased in a retrospectively collected cohort. However, only a few studies have mentioned possible factors biasing patient selection for repeat biopsy after a diagnosis of ASAP (12,14). One study reported that patients with a repeat biopsy were younger than those without a repeat biopsy (14), and the other reported that patients with a repeat biopsy had a higher Charlson Comorbidity Index score than patients without a repeat biopsy (12).…”

Section: Discussionmentioning

confidence: 99%

“…Remarkably, the probability of cancer found on repeat biopsy ranges from 20.0 to 71.6% (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). Clinical and pathological predictors reported for cancer detection on repeat biopsy after an ASAP diagnosis vary among studies (7,12,16,18,23,24), but these variations could result from the retrospective nature of the studies. Of note, most of the studies lacked information on factors that could influence patient selection for repeat biopsy after a diagnosis of ASAP on initial biopsy, which would be crucial to interpreting the results.…”

Section: Introductionmentioning

confidence: 99%

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Implementation of repeat biopsy and detection of cancer after a diagnosis of atypical small acinar proliferation of the prostate

et al. 2020

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Current guidelines recommend a repeat biopsy within 3-6 months after an initial diagnosis of atypical small acinar proliferation (ASAP) due to the high incidence of cancer detection on repeat biopsy. The current study sought to investigate practice patterns after a diagnosis of ASAP in a real-world setting and examine the clinicopathological outcomes of repeat biopsy. The departmental database of the Hyogo Prefectural Nishinomiya Hospital identified 97 of 1,218 patients with a diagnosis of ASAP on initial biopsy from 2011 to 2016. Clinical and pathological data were retrospectively analyzed. Of the 97 patients, 34 (35.1%) underwent a repeat biopsy. Patients with a repeat biopsy had a significantly higher prostate-specific antigen (PSA) velocity and shorter PSA doubling time than patients without a repeat biopsy (P= 0.0002), and of these 34 patients with a repeat biopsy, 16 (47.1%) were diagnosed as having cancer. Multivariate logistic regression analysis revealed that a small prostate (P= 0.0250) and advanced age (P= 0.0297) were associated with cancer detection on repeat biopsy. Of the 16 cancers identified, 13 (81.6%) were diagnosed with a Gleason score >6. The results indicated that the implementation of a repeat biopsy for patients with ASAP could be affected by clinical characteristics in real-world settings, despite the current recommendation of guidelines endorsing immediate repeat biopsy. Prostate volume and age would aid in the decision-making process to perform repeat biopsy in patients with high PSA velocity and short PSA doubling time after a diagnosis of ASAP.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Implementation of repeat biopsy and detection of cancer after a diagnosis of atypical small acinar proliferation of the prostate

et al. 2020

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“…One issue to be clarified is that dietary Zn intake has been linked to increased risk of kidney stones in the adult (yet not in adolescent) individuals, while inhibiting Zn excretion was found to reduce cyst formation in the fly. One of the possible ways to interpret these apparently contradicting results posits that Zn may promote formation of different crystals depending on concentration [ 94 ] and indicates the need to probe additional physiological parameters in future studies to capture the complexity of kidney stone formation.…”

Section: Malpighian Tubules To Model Diseasementioning

confidence: 99%

Modeling Renal Disease “On the Fly”

Millet-Boureima

Marroquin

Gamberi

2018

BioMed Research International

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Detoxification is a fundamental function for all living organisms that need to excrete catabolites and toxins to maintain homeostasis. Kidneys are major organs of detoxification that maintain water and electrolyte balance to preserve physiological functions of vertebrates. In insects, the renal function is carried out by Malpighian tubules and nephrocytes. Due to differences in their circulation, the renal systems of mammalians and insects differ in their functional modalities, yet carry out similar biochemical and physiological functions and share extensive genetic and molecular similarities. Evolutionary conservation can be leveraged to model specific aspects of the complex mammalian kidney function in the genetic powerhouse Drosophila melanogaster to study how genes interact in diseased states. Here, we compare the human and Drosophila renal systems and present selected fly disease models.

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“…In the Chronic Renal Insufficiency Cohort (CRIC), plasma levels of the cytokines interleukin1β (Il-1β), the interleukin-1 receptor antagonist (IL-1RA), interleukin-6 (IL-6), tumor necrosis factor (TNF)-α, as well as high sensitivity C-reactive protein (CRP) and fibrinogen were higher among participants with reduced levels of estimated glomerular filtration rate (eGFR) [ 12 ], and are associated with progressive loss of kidney function [ 13 ]. Only recently, the role of the gut in CKD associated inflammation has been recognized [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Intestinal Barrier Function in Chronic Kidney Disease

Meijers

Farré

Dejongh

et al. 2018

Toxins

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The kidneys are key contributors to body homeostasis, by virtue of controlled excretion of excessive fluid, electrolytes, and toxic waste products. The syndrome of uremia equals the altered physiology due to irreversible loss of kidney function that is left uncorrected for, despite therapeutic intervention(s). The intestines and its microbial content are prime contributors to this syndrome. The intestinal barrier separates the self (or the so-called “milieu intérior”) from the environment. In the large intestine, the intestinal barrier keeps apart human physiology and the microbiota. The enterocytes and the extracellular mucin layer functions form a complex multilayered structure, facilitating complex bidirectional metabolic and immunological crosstalk. The current review focuses on the intestinal barrier in chronic kidney disease (CKD). Loss of kidney function results in structural and functional alterations of the intestinal barrier, contribution to the syndrome of uremia.

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Atypical small acinar proliferation at index prostate biopsy: rethinking the re-biopsy paradigm

Cited by 9 publications

References 31 publications

Implementation of repeat biopsy and detection of cancer after a diagnosis of atypical small acinar proliferation of the prostate

Implementation of repeat biopsy and detection of cancer after a diagnosis of atypical small acinar proliferation of the prostate

Modeling Renal Disease “On the Fly”

Intestinal Barrier Function in Chronic Kidney Disease

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