Atypical Skeletal Muscle Profiles in Human Immunodeficiency Virus-Infected Asymptomatic Middle-Aged Adults

Tran, Thanh Nga; Guardigni, Viola; Pencina, Karol M.; Amato, Anthony A.; Floyd, Michael S.; Brawley, Brooke; Mozeleski, Brian; McKinnon, Jennifer; Woodbury, Erin; Heckel, Emily; Li, Zhuoying; Storer, Tom; Sax, Paul E.; Montano, Monty

doi:10.1093/cid/cix1121

Cited by 26 publications

(36 citation statements)

References 41 publications

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“…However, using accelerometry in a follow-up study, volitional gait speed by activity tracker was significantly reduced compared to the uninfected participants. 26,27 Consistent with this observation, male PWH spent significantly more time in the lowest quartile of PA compared to the seronegative controls. 26 Collectively, asymptomatic PWH on effective ART were characterized by subclinical deficits in physical function, greater levels of fatigue and estimated mortality risk (by the VACS Index), elevated inflammation and immune activation, and increased skeletal muscle internalized nuclei with decreased PGC-1a.…”

Section: Preclinical Decline and Asynchronous Aging In Hivsupporting

confidence: 62%

“…Summary data were presented on emerging deficits in function in middle-aged PAWH. 26,27 Jennifer Schrack discussed energy expenditure and aging and presented data that profiled HIV-related decline in aerobic capacity with age and increasing burden of multimorbidity on energy reserves and metabolism. 24,28,29 Summary data indicated that PWH have higher resting metabolic rates, slower peak and usual walking speed, lower aerobic capacity, and lower physical activity (PA).…”

Section: Overview Of Workhop Presentationsmentioning

confidence: 99%

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Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research

Montano

Bhasin

D’Aquila

et al. 2019

AIDS Research and Human Retroviruses

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People aging with HIV (PAWH) infection experience greater impairments in physical and cognitive function, in addition to higher rates of peripheral comorbid conditions (e.g., renal failure, diabetes, bone fracture, hypertension, cardiovascular disease, polypharmacy, and multimorbidity). While multifactorial drivers, including HIV infection itself, antiretroviral therapy-related toxicities, disparities in care, and biobehavioral factors, likely contribute, there remains an overarching question as to what are the relevant age-related mechanisms and models that could inform interventions that promote health span and life span in PAWH? This workshop was convened to hear from experts on the biology of aging and HIV researchers studying PAWH to focus on advancing investigations at the interface of HIV and Aging. In this study, we summarize the discussions from the Harvard Center for AIDS Research and Boston Claude D. Pepper cosponsored workshop on HIV and Aging, which took place in October 2018.

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Section: Preclinical Decline and Asynchronous Aging In Hivsupporting

confidence: 62%

Section: Overview Of Workhop Presentationsmentioning

confidence: 99%

Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research

Montano

Bhasin

D’Aquila

et al. 2019

AIDS Research and Human Retroviruses

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“…[1][2][3] The proportion of PLWH with fatigue is estimated to range from 30% to as much as 90%, 2 4 which is far more frequent than their HIV-negative counterparts. 5 The presence of fatigue in PLWH contributes to lower quality of life and worsened health outcomes. 2 6 7 Interventions to prevent or treat fatigue among PLWH are being investigated.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of non-pharmacological interventions to decrease fatigue in people living with HIV/AIDS: a protocol of systematic review and meta-analysis

et al. 2020

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IntroductionFatigue is a common symptom among people living with HIV (PLWH). It has a substantial adverse impact on functional status and the ability to conduct activities of daily living. Identifying effective strategies to prevent or reduce fatigue is significant to promote the quality of life of this vulnerable population. The purpose of this review is to synthesise the non-pharmacological evidence and assess the effects of interventions on reducing HIV-related fatigue among PLWH.Methods and analysisWe will comprehensively search literature available up to 30 June 2020, in the following databases: PubMed, Embase, CINAHL, Cochrane Library, Web of Science and PsycINFO. The reference list of selected studies and relevant published reviews will also be screened to retrieve potential articles. Two reviewers will identify the eligible articles, extract data and identify the biases in the selected studies. Any disagreements will be referred to a third reviewer. We will qualitatively synthesise the evidence and pool data with meta-analysis according to the heterogeneity of different studies.Ethics and disseminationThis systematic review will not raise any ethical issues since it is a secondary data collection and analysis. The results will inform effective strategies to reduce fatigue among PLWH. The final report will be published in a peer-reviewed journal and academic conferences.PROSPERO registration numberCRD42020153715.

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“…This study included participants in the MATCH (Muscle and Aging in Treated Chronic HIV) cohort of middle-aged men and women living with HIV and uninfected control participants of similar age [25]. Overall, HIV+ participants in the MATCH cohort are relatively healthy but displayed increased levels of inflammation and immune activation compared with their uninfected counterparts and displayed modest but significant subclinical deficits in lab-based physical function [25]. However, when men and women were analyzed separately, we noticed that performance in the lab-based 6-minute walk test (6-MWT) in men did not reach significance despite reporting greater fatigue [25].…”

Section: Introductionmentioning

confidence: 99%

“…Overall, HIV+ participants in the MATCH cohort are relatively healthy but displayed increased levels of inflammation and immune activation compared with their uninfected counterparts and displayed modest but significant subclinical deficits in lab-based physical function [25]. However, when men and women were analyzed separately, we noticed that performance in the lab-based 6-minute walk test (6-MWT) in men did not reach significance despite reporting greater fatigue [25]. We hypothesized that measuring physical activity in daily life using consumer-grade accelerometers might provide additional information, potentially detecting subclinical deficits that do not as yet reach significance in the lab-based assessment of gait speed.…”

Section: Introductionmentioning

confidence: 99%

Middle-Aged Men With HIV Have Diminished Accelerometry-Based Activity Profiles Despite Similar Lab-Measured Gait Speed: Pilot Study

Hale

Guardigni

Roitmann³

et al. 2019

JMIR Mhealth Uhealth

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Background People aging with HIV are living with increased risk for functional decline compared with uninfected adults of the same age. Early preclinical changes in biomarkers in middle-aged individuals at risk for mobility and functional decline are needed. Objective This pilot study aims to compare measures of free-living activity with lab-based measures. In addition, we aim to examine differences in the activity level and patterns by HIV status. Methods Forty-six men (23 HIV+, 23 HIV−) currently in the MATCH (Muscle and Aging Treated Chronic HIV) cohort study wore a consumer-grade wristband accelerometer continuously for 3 weeks. We used free-living activity to calculate the gait speed and time spent at different activity intensities. Accelerometer data were compared with lab-based gait speed using the 6-minute walk test (6-MWT). Plasma biomarkers were measured and biobehavioral questionnaires were administered. Results HIV+ men more often lived alone ( P =.02), reported more pain ( P =.02), and fatigue ( P =.048). In addition, HIV+ men had lower blood CD4/CD8 ratios ( P <.001) and higher Veterans Aging Cohort Study Index scores ( P =.04) and T-cell activation ( P <.001) but did not differ in levels of inflammation ( P =.30) or testosterone ( P =.83). For all participants, accelerometer-based gait speed was significantly lower than the lab-based 6-MWT gait speed ( P <.001). Moreover, accelerometer-based gait speed was significantly lower in HIV+ participants ( P =.04) despite the absence of differences in the lab-based 6-MWT ( P =.39). HIV+ participants spent more time in the lowest quartile of activity compared with uninfected ( P =.01), who spent more time in the middle quartiles of activity ( P =.02). Conclusions Accelerometer-based assessment of gait speed and activity patterns are lower for asymptomatic men living with HIV compared with uninfected controls and may be useful as preclinical digital biomarkers that precede differences captured in lab-based measures.

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Atypical Skeletal Muscle Profiles in Human Immunodeficiency Virus-Infected Asymptomatic Middle-Aged Adults

Abstract: NCT03011957.

Cited by 26 publications

References 41 publications

Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research

Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research

Effectiveness of non-pharmacological interventions to decrease fatigue in people living with HIV/AIDS: a protocol of systematic review and meta-analysis

Middle-Aged Men With HIV Have Diminished Accelerometry-Based Activity Profiles Despite Similar Lab-Measured Gait Speed: Pilot Study

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