Atypical Retardation Patterns in Scanning Laser Polarimetry Are Associated with Low Peripapillary Choroidal Thickness

Tornow, Ralf P.; Schrems, W.; Bendschneider, D; Horn, Folkert K.; Mayer, Markus A.; Mardin, Christian Y.; Laemmer, Robert

doi:10.1167/iovs.11-7557

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Although it may also be the case that the choroid is thicker in Korean eyes, Chung et al33 measured PCT using Spectralis circle scans in 87 healthy Korean eyes and reported an average thickness of 157.3 μm, which is within the confidence intervals of our measurements at 900 and 1000 μm (roughly the position of a standard circle scan within our data). Several other studies have reported global PCT within standard 12° (or 3.4 mm diameter) circle scans in a wide variety of healthy participants that varies from 130 μm to 167 μm,34–42 which are again within the confidence intervals of our measurements at the PCT-900 μm and PCT-1000 μm measurement points.…”

Section: Discussionsupporting

confidence: 87%

Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

Yang

Luo

Gardiner

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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Purpose To quantify peripapillary choroidal thickness (PCT) and the factors that influence it in healthy participants who represent the racial and ethnic composition of the U.S. population. Methods A total of 362 healthy participants underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head with a 24 radial B-scan pattern aligned to the fovea to Bruch's membrane opening axis. Bruch's membrane, anterior scleral canal opening (ASCO), and the anterior scleral surface were manually segmented. PCT was measured at 100, 300, 500, 700, 900, and 1100 μm from the ASCO globally and within 12 clock-hour sectors. The effects of age, axial length, intraocular pressure, ethnicity, sex, sector, and ASCO area on PCT were assessed by ANOVA and univariable and multivariable regressions. Results Globally, PCT was thicker further from the ASCO border and thinner with older age, longer axial length, larger ASCO area, European descent, and female sex. Among these effectors, age and axial length explained the greatest proportion of variance. The rate of age-related decline increased further from the ASCO border. Sectorally, the inferior-temporal sectors were thinnest (10.7%–20.0% thinner than the thickest sector) and demonstrated a higher rate of age-related loss (from 15.6% to 20.7% faster) at each ASCO distance. Conclusions In healthy eyes, PCT was thinnest in the inferior temporal sectors and thinner PCT was associated with older age, European descent, longer axial length, larger ASCO area, and female sex. Among these associations, age had the strongest influence, and its effect was greatest within the inferior temporal sectors.

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Section: Discussionsupporting

confidence: 87%

Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

Yang

Luo

Gardiner

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…It was shown that these artifacts occur in eyes that provide a deep penetration of the sampling beam into the birefringent sclera, 23 an effect likely related to a thin choroid. 24 SLP has no depth segmentation capability and, therefore, the origin of the birefringence cannot be localized. Although recently the enhanced cornea compensation (ECC) version of the SLP has reduced these artifacts, 21,25 PS-OCT can overcome this limitation completely because it provides depth resolved information.…”

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confidence: 99%

Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Zotter

Pircher

Götzinger

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We presented a novel polarization sensitive optical coherence tomography (PS-OCT) system for measuring retinal nerve fiber layer (RNFL) birefringence, retardation, and thickness, and report on the repeatability of acquiring these quantities. METHODS.A new PS-OCT system, measuring at 840 nm, was developed that supports scan angles of up to 408 3 408 with an A-scan rate of 70 kHz. To test the performance and reproducibility, we measured 10 eyes of 5 healthy human volunteers five times each. All volunteers were imaged further with scanning laser polarimetry (SLP). The obtained RNFL birefringence, retardation, and thickness maps were averaged, and standard deviation maps were calculated. For quantitative comparison between the new PS-OCT and SLP, a circumpapillary evaluation within 2 annular segments (superior and inferior to the optic disc) was performed.RESULTS. High quality RNFL birefringence, retardation, and thickness maps were obtained. Within the superior and inferior segments, the mean retardation for individual eyes ranged from 208 to 28.98 and 17.28 to 28.28, respectively. The quadrant precision over the 5 consecutive measurements for each subject, calculated for the average retardation obtained within the superior and inferior quadrants ranged from 0.168 to 0.698. The mean birefringence ranged from 0.1068/lm to 0.1418/lm superior and 0.1018/lm to 0.1358/lm inferior, with a quadrant precision of 0.0018/lm to 0.0078/lm. The mean RNFL thickness varied from 114 to 150 lm superior, and 111 to 140.9 lm inferior (quadrant precision ranged from 3.6 to 11.9 lm). CONCLUSIONS.The new PS-OCT system showed high image quality and reproducibility, and, therefore, might be a valuable tool for glaucoma diagnosis. (Invest Ophthalmol Vis Sci. 2013; 54:72-84)

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Glaucoma Diagnostic Performance of GDxVCC and Spectralis OCT on Eyes With Atypical Retardation Pattern

Hoesl¹,

Tornow²,

Schrems³

et al. 2013

Journal of Glaucoma

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Diagnostic accuracy is comparable for SD-OCT and GDxVCC if typical scans (TSS=100) are investigated. Decreasing TSS is associated with a decrease in diagnostic accuracy for discriminating healthy and glaucomatous eyes by scanning laser polarimetry. NFI is less influenced than the global or sector retinal nerve fiber layer thickness. The TSS score should be included in the standard printout. Diagnostic accuracy of SD-OCT is barely influenced by low TSS.

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Atypical Retardation Patterns in Scanning Laser Polarimetry Are Associated with Low Peripapillary Choroidal Thickness

Abstract: Low values of TSS resulting from the appearance of ARP in SLP are associated with low peripapillary choroidal thickness. Reduced choroidal thickness may result in an increased amount of confounding light getting to the SLP light detectors.

Cited by 4 publications

References 22 publications

Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Glaucoma Diagnostic Performance of GDxVCC and Spectralis OCT on Eyes With Atypical Retardation Pattern

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