Atypical renal adenocarcinoma with features suggesting collecting duct origin and mimicking a mucinous adenocarcinoma

Halenda, Gregory M.; Sees, Jackie N.; Belis, John A.; Rohnr, Thomas J.

doi:10.1016/0090-4295(93)90174-9

Cited by 14 publications

(4 citation statements)

References 13 publications

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“…14 Mitotic figures are frequently present and histochemically both acid and neutral mucin may be seen. 15 In addition to the tubulopapillary architecture, these tumors may also contain compact papillary structures, solid sheet-like areas of tumor cells and microcysts. Occasionally foci of spindle cells are present, however, if this is more than a rare occurrence, the tumor should be considered to be a sarcomatoid carcinoma arising within a collecting-duct carcinoma.…”

Section: Collecting-duct Carcinomamentioning

confidence: 99%

Uncommon and recently described renal carcinomas

2009

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Major consensus conferences held over a decade ago laid the foundations for the current (2004) WHO classification of renal carcinoma. Clear cell, papillary and chromophobe carcinomas account for 85-90% carcinomas seen in routine practice. The remaining 10-15% of carcinomas consist of rare sporadic and hereditary tumors, some of which had been long recognized, but many of which only emerged as distinct entities in the decade leading up to the WHO publication. Collecting-duct carcinoma is a rare, often lethal form of carcinoma. Medullary carcinoma associated with sickle cell trait, has emerged as a distinctive tumor showing some overlapping features with upper tract urothelial carcinoma. Mucinous tubular and spindle-cell carcinoma and tubulocystic carcinoma were earlier considered as patterns of low-grade collecting-duct carcinoma, but are now recognized as separate tumor entities. Carcinomas associated with somatic translocations of TFE3 and TFEB comprise a significant proportion of pediatric renal carcinomas. Oncocytoid renal carcinomas in neuroblastoma survivors was recognized as a unique tumor category in the WHO classification. Renal carcinoma associated with end-stage renal disease is now recognized as having distinct morphological patterns and behavior. In addition there is a group of rare recently described carcinomas, including clear cell papillary carcinoma, oncocytic papillary renal cell carcinoma, follicular renal carcinoma and leiomyomatous renal cell carcinoma. It behooves the surgical pathologist to not only be capable of diagnosing the common forms of renal cancer, but also to be aware of the rare types of renal carcinoma, many of which have emerged in recent years.

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Section: Collecting-duct Carcinomamentioning

confidence: 99%

Uncommon and recently described renal carcinomas

2009

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“…Distinguishing features of collecting duct carcinoma include a cystic to papillary appearance on gross examination, location in the renal pelvis and/or medulla, predominantly tubular and papillary growth pattern, and atypical hyperplasia of the adjacent collecting duct epithelium [6,8,9]. Both Recently, it has been suggested that renal medullary carcinoma should be considered a distinct entity, having formerly been included under the umbrella of collecting duct carcinoma, a poorly defined and heterogeneous category of uncommon renal tubular epithelial neoplasms that may potentially include several different tumors [ 131.…”

Section: Discussionmentioning

confidence: 99%

Renal Medullary Carcinoma: A Potential Sickle Cell Nephropathy of Children and Adolescents

Wesche

Wilimas

Khare

et al. 1998

Pediatric Pathology & Molecular Medicine

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A n extremely aggressive malignant epithelial neoplasm ofthe kidney has recently been described and named renal medullary careinoma. The finding ofthis tumor is highly predictive of drepanocytes (sickle cells) in tissue sections and thus the presence of sickle hemoglobin, specifically sickle cell trait, in the patient. We present a case report of this rare tumor in a 10-year-old male. The tumor displayed a variable histologic architecture includinggland-like areas with intra-and extracytoplasmic material resembling mucin with hematoxylin and eosin stain. This material was negative with periodic aeid-Schijf and mueicannine stains, stained only weakly with Alcian Blue, and was positive using antibodies against peanut agglutinin. Tumor cells stained positively with antibodies to epithelial membrane antigen, cytokeratin, vimentin, and Ulex europaeus lectin. The luminalface of tumor cells stained with peanut agglutinin. Stains usinguntibodies against careinoembryonic antigen and alpha-fetoprotein were negative. Ultrastructurally, the tumor cells were charactm.zed by short microvilli lining the luminal surface and lateral complex infoldings of adjacent plasma membranes. We discuss the relationship of this neoplasm to another renal pelvic neoplasm, collecting duct careinoma, which may rarely occur in children. Renal medullary carcinoma should be included in the dijferential diagnosis ofgross hematuria, which is most commonly benign self-limited hematuria, in young patients with sickle cell trait.

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“…C D C frequently presents as a renal mass causing flank pain and hematuria (Dimopoulos et al, 1993). These lesions are often mistaken preoperatively for RCC or transitional cell carcinoma (TCC) of the renal pelvis and CDC frequently shows evidence of metastatic disease (Mancilla-Jimenez et al, 1976;Cromie et al, 1979;Aizawa et al, 1986;Fleming and Lewi, 1986;Kennedy et al, 1990;Rumpelt et al, 1991;Carter et al, 1992;Fuzesi et al, 1992;Miyamoto et al, 1992;Dimopoulos et al, 1993;Halenda et al, 1993). CDCs can be differentiated from RCC on the basis of a constellation of gross and microscopic features (Table 1).…”

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confidence: 99%

“…To improve our understanding of CDC biology and to explore the possibility that known and pu- tative T S G may be involved in the etiology of these tumors, we analyzed 6 CDCs by using microsatellite markers on multiple chromosomal arms to search for evidence of LOH. Formalin-fixed, paraffin-embedded, nonmalignant and tumor tissues from 5 previously reported cases of C D C were generously donated by the authors of several reports (Carter et al, 1992;Miyamoto et al, 1992;Brooks et al, 1993;Halenda et al, 1993). An additional, unreported case was identified in the Johns Hopkins Hospital Pathology archive and is included in this series (Table 2).…”

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confidence: 99%

Frequent Loss of Chromosome Arms 8p and 13q in Collecting Duct Carcinoma (CDC) of the Kidney

Schoenberg

Brooks

Marshall

et al. 1995

Genes Chromosomes & Cancer

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Collecting duct carcinoma (CDC) is a malignant renal neoplasm that is believed to arise from the epithelium of the ducts of Bellini in the distal nephron. These tumors are clinically aggressive and more often occur in a younger population than is typical of the more common clear cell renal carcinoma (RCC). Using highly informative polymorphic microsatellite markers on chromosome arms 3p, 5q, 6q, 9p, 9q, 11p, 13q, 17p, and 18q, we analyzed DNA from nonmalignant and tumor tissue in 6 cases of CDC. We found no evidence of 3p loss of heterozygosity (LOH) in these renal tumors by using multiple markers, a finding that distinguishes CDC from RCC in which 3p LOH has frequently been observed. We found LOH of 8p in 50% of the tumors examined; in addition, we observed LOH of 13q in 50% of the tumors studied. Interestingly, 8p LOH may be associated with high stage and poor clinical prognosis. These data suggest that the molecular events responsible for the development of CDC differ from those associated with the origin of RCC, and that tumor suppressor genes on 8p and 13q may be involved in the pathogenesis of CDC.

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Atypical renal adenocarcinoma with features suggesting collecting duct origin and mimicking a mucinous adenocarcinoma

Cited by 14 publications

References 13 publications

Uncommon and recently described renal carcinomas

Uncommon and recently described renal carcinomas

Renal Medullary Carcinoma: A Potential Sickle Cell Nephropathy of Children and Adolescents

Frequent Loss of Chromosome Arms 8p and 13q in Collecting Duct Carcinoma (CDC) of the Kidney

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