Atypical Presentations of Benign Retroperitoneal Schwannoma: Report of Three Cases with Review of Literature

Singh, Vishwajeet; Kapoor, Rakesh

doi:10.1007/s11255-004-4705-5

Cited by 50 publications

(39 citation statements)

References 8 publications

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“…T�ey ��e o�din��i�y seen in ��e �e�d, neck, �nd exi�y seen in ��e �e�d, neck, �nd exseen in ��e �e�d, neck, �nd ex� tremities�� an�� are on�� rare�� oun�� in the retro�eritone� um; � �e��o�e�i�one�� oc��ion �ccoun�ed �o� 0.3%-3.2% 3%-3.2% -3.2% 3.2% % o� a�� rimar� schwannomas [2][3][4][5][6] 6] �nd 0.3%-6.0% o� �� 0.3%-6.0% o� �� retro�eritonea�� tumors [7][8][9][10][11][12] . �s ��evious�y desc�ibed, �� indings o� sc��nnom�s gene��y s�o� � �e��-defined �y�oec�oic m�ss �i�� s�ig��y �e�e�ogeneous in�e�n�� ec�o �eve�.…”

Section: Discussionmentioning

confidence: 99%

Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA

Kudo

Kawakami²,

Kuwatani³

et al. 2011

WJG

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Schwannomas are peripheral nerve tumors that are typically solitary and benign. Their diagnosis is largely based on surgically resected specimens. Recently, a number of case reports have indicated that retroperito� neal schwannomas could be diagnosed with endoscopic endoscopic ultrasound�guided fine�needle aspiration �E�S�FNA�.�guided fine�needle aspiration �E�S�FNA�. �needle aspiration �E�S�FNA�. needle aspiration �E�S�FNA�. We report the diagnosis of three cases of schwannoma using E�S�FNA. Subjects were two males and one fe� two males and one fe� wo males and one fe� male, ages 22, 40, and 46 years, respectively, all of whom were symptom�free. Imaging findings showed well�circumscribed round tumors. However, as the s. However, as the . However, as the tumors could not be diagnosed using these findings alone, E�S�FNA was performed. Hematoxylin�eosin staining of the resulting tissue fragments revealed bland spindle cells with nuclear palisading. There was no disparity in nuclear sizes. Immunostaining revealed nuclear sizes. Immunostaining revealed nuclear sizes. Immunostaining revealed S�100 protein positivity and all cases were diagnosed as schwannomas. Ki�67 indexes were ��1��, 2��, es were ��1��, 2��, were ��1��, 2��, and ��, respectively. No case showed any signs of ma� lignancy. As most schwannomas are benign tumors and ost schwannomas are benign tumors and schwannomas are benign tumors and benign tumors and benign tumors and s and and seldom become malignant, we observed these patients without therapy. All tumors demonstrated no enlarge� no enlarge� enlarge� ment and no change in characteristics. Schwannomas and no change in characteristics. Schwannomas no change in characteristics. Schwannomas are almost always benign and can be observed follow� ing diagnosis by E�S�FNA. Key words: Schwannoma; Endoscopic ultrasonography; ndoscopic ultrasonography; ultrasonography; ltrasonography; nography; Fine�needle aspiration; Retroperitoneal tumor; S100 ine�needle aspiration; Retroperitoneal tumor; S100 �needle aspiration; Retroperitoneal tumor; S100 needle aspiration; Retroperitoneal tumor; S100 ; Retroperitoneal tumor; S100 proteins; Ki�67 index

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Section: Discussionmentioning

confidence: 99%

Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA

Kudo

Kawakami²,

Kuwatani³

et al. 2011

WJG

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“…Schwannoma rarely arises from the kidneys with only 19 cases reported ( Table 2). [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Clinical presentations include abdominal or flank pain (12 cases), 2,4-6,8,10,11,13 microhematuria (2 cases), 3,15 or fever (4 cases). 4,6,10,11 Sometimes patients are asymptomatic and the finding is incidental.…”

Section: Discussionmentioning

confidence: 99%

“…1 Schwannomas are rare in the kidneys, and only 19 cases have been reported. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] We report herein the clinicopathologic features of three additional cases of renal schwannoma.…”

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confidence: 99%

Schwannoma of the Kidney

et al. 2008

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Schwannomas of the kidney are rare, with only a few reported cases. We report three additional cases with immunohistochemical analysis. All three tumors were from females (aged 27, 35, and 59 years) and ranged from 4.8 to 8 cm in diameter. All of the patients underwent nephrectomy. The tumors were totally or partially encapsulated; two were in the hilum and one was centered in the renal cortex. All tumors were diffusely positive for S100 protein. Two were positive for neuron-specific enolase. Immunostaining for neurofilament, HMB45, microphthalmia transcription factor, smooth muscle actin, CD34, cytokeratin AE1/3, cytokeratin 7, and CD10 were negative. Follow-up data were available for two patients; neither had tumor recurrence or metastasis. In conclusion, renal schwannoma is rare, usually arises centrally, impinging on the hilum or the pelvis, and is cured by resection. Sarcomatoid carcinoma and other spindle cell tumors should be considered in the differential diagnosis.

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“…It arises from the Schwann cells, is circumscribed and appears encapsulated by epineurium, bulges eccentrically from the originating nerve [1][2][3]. Tumour size does not usually exceed a diameter of 5-6 cm.…”

Section: Introductionmentioning

confidence: 99%

“…Tumour size does not usually exceed a diameter of 5-6 cm. Large schwannomas are found very rarely, only 0.3-5% of all cases [1][2][3][4][5][6][7]. Most of them are found in the retroperitoneal space.…”

Section: Introductionmentioning

confidence: 99%

Retroperitoneal giant schwannoma eroding lumbal vertebra: A case report with a literature review

et al. 2008

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AbstractA huge schwannoma, located in the retroperitoneal space, is found very rarely. The main purpose of this paper is to present the case of a giant retroperitoneal schwannoma which partly invaded L4 vertebral body. The secondary purpose is to summarize the case-report articles on retroperitoneal schwannomas. A circumscribed heterogenic tumour was revealed on transabdominal sonography. It extended into the right retroperitoneal space. CT and MRI revealed a paravertebral tumour in the size of 11 cm × 9 cm, which is causing a partial lysis of L4 vertebral body (15% of vertebral capacity), expanding intravertebral foramen and filling the right retroperitoneal space. A preoperative core needle biopsy was performed and a benign schwannoma was diagnosed. A complete surgical excision of the tumour was achieved by a two-step operation. During the first step, the neurosurgeons made L4 hemilaminectomy, facetectomy and a transverse process resection by posterior extended approach. The general surgeons excised the residual retroperitoneal part of the tumour by midline transabdominal approach 10 days later. The diagnosis of benign schwannoma was verified histochemically. There were no sign of tumour recurrence or spine destabilization at the six-month follow-up. In conclusion, although majority of giant retroperitoneal schwannomas can be completely removed performing one-step operation, a preoperative consideration about rationality of two-step operation should be mandatory when tumour destructs a part of vertebral body. Our case shows that the combined two stage complete surgical excision of a giant retroperitoneal schwannoma, eroding 15% of L4 vertebra’s osseous capacity, is effective and does not have any negative influence on spinal stability.

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Atypical Presentations of Benign Retroperitoneal Schwannoma: Report of Three Cases with Review of Literature

Cited by 50 publications

References 8 publications

Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA

Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA

Schwannoma of the Kidney

Retroperitoneal giant schwannoma eroding lumbal vertebra: A case report with a literature review

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