Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports

Sountoulides, Petros; Metaxa, Linda; Cindolo, Luca

doi:10.1186/1752-1947-5-429

Cited by 161 publications

(212 citation statements)

References 74 publications

(58 reference statements)

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“…10,11 Surgical resection is a possible treatment for these metastases, but metastases' accessibility and resectability, and patients' performance and comorbidities have to be taken into account. 12 Radiotherapy modalities can provide valid local noninvasive treatment alternatives to surgery.…”

Section: Introductionmentioning

confidence: 99%

Local treatments for metastases of renal cell carcinoma: a systematic review

Dabestani

Marconi

Hofmann

et al. 2014

The Lancet Oncology

283

205

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Local treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefi ts and harms of various local treatments, we did a systematic review of all types of comparative studies on local treatment of metastases from renal cell carcinoma in any organ. Interventions included metastasectomy, radiotherapy modalities, and no local treatment. The results suggest that patients treated with complete metastasectomy have better survival and symptom control (including pain relief in bone metastases) than those treated with either incomplete or no metastasectomy. Nevertheless, the available evidence was marred by high risks of bias and confounding across all studies. Although the fi ndings presented here should be interpreted with caution, they and the identifi ed gaps in knowledge should provide guidance for clinicians and researchers, and directions for further research.

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Section: Introductionmentioning

confidence: 99%

Local treatments for metastases of renal cell carcinoma: a systematic review

Dabestani

Marconi

Hofmann

et al. 2014

The Lancet Oncology

283

205

View full text Add to dashboard Cite

show abstract

“…This is most likely attributable to the relatively aggressive nature of RCC, with its tendency to metastasize [3]. Common sites of RCC metastases are lungs, bone, liver and lymph nodes [3]. However, there have been reports of metastases to rare sites including urogenital organs, particularly the vagina and the vulva, which we have presented in our case [3].…”

Section: Discussionmentioning

confidence: 55%

“…Despite an increasing incidence of incidental finding of renal cancers on unplanned imaging, a third of them still have metastases at presentation [3]. This is most likely attributable to the relatively aggressive nature of RCC, with its tendency to metastasize [3].…”

Section: Discussionmentioning

confidence: 99%

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Untitled

2017

UNOAJ

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Renal cell carcinoma is an aggressive cancer, which could explain why as many as a third of cases are diagnosed as metastatic at presentation. With the incidence of renal cell carcinoma on the rise and a 5-year survival rate of just over 10% with metastatic disease, it is important to highlight the role of early detection of this cancer in order to optimize management and improve outcomes. Vulva and vagina represent rare sites for metastases from renal cell cancer, with clear cell renal cell cancer accounting for about a fifth of metastatic vulval cancer. We focus on this rare presentation of vulvo-vaginal metastases from renal clear cell carcinoma by presenting an unusual case of per-vaginal bleeding 3 months following detection of a renal lesion on CT imaging and highlight the importance of having a multidisciplinary approach to managing such complex cases to provide patients with the best possible outcomes.

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“…Abdominal ultrasound is a convenient and reliable tool in the diagnosis of gallbladder tumors. Metastases can appear as hyperechoic masses bigger than 1 cm in diameter, close to the gallbladder wall without posterior acoustic shadowing [9][10][11][12]. A CT sign that can help in the differentiation between primary gallbladder tumors and metastases is the invasion of the mucosal layer.…”

Section: Discussionmentioning

confidence: 99%

Isolated Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature

Mitsimponas¹

2017

Ann Hematol Oncol

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Isolated gallbladder metastasis from renal cell carcinoma is a very rare clinical entity with a significant male predominance. Until now, only 22 cases have been reported in the medical literature. Most cases occurred after very prolonged disease-free intervals. We report a case of metachronous isolated gallbladder metastasis of 15 mm size in a 72 yr old gentleman, 12 years after subtotal nephrectomy of the upper pole of the right kidney for clear cell renal cell carcinoma. At the time of diagnosis, the patient suffered from concurrent aggressive B-cell non-Hodgkin's lymphoma which was treated aggressively, including autologous bone marrow transplantation. Gallbladder resection was performed after treatment of the hematological malignancy. Small polypoid structures in the gallbladder of patients with antecedents of renal cell carcinoma should prompt surgical resection even if the size in ultrasound does not reach internationally accepted intervention thresholds for benign gall bladder polyps.

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Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports

Cited by 161 publications

References 74 publications

Local treatments for metastases of renal cell carcinoma: a systematic review

Local treatments for metastases of renal cell carcinoma: a systematic review

Untitled

Isolated Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature

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