Atypical presentation of progressive young onset dementia

Elhusein, Bushra; Radwan, Ahmed; Khairi, Abdalla; Ahmed, Mohamed Eldigire

doi:10.1136/bcr-2018-225754

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Large household is even more important for pre-dementia patient, especially the young onset dementia. Generally, young onset dementia present non-specific signs and symptoms at the early onset in young patient, but they are progressing and irreversible [ 119 ]. With household residents’ observations and encouragement, the atypical dementia symptoms can be noticed by co-residential members, and accordingly they can have the examination in time, and proper treatment subsequently.…”

Section: Discussionmentioning

confidence: 99%

Large household reduces dementia mortality: A cross-sectional data analysis of 183 populations

You

Henneberg

2022

PLoS ONE

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Background Large households/families may create more happiness and offer more comprehensive healthcare among the members. We correlated household size to dementia mortality rate at population level for analysing its protecting role against dementia mortality. Methods This is a retrospective cross-sectional study. Dementia specific mortality rates of the 183 member states of World Health Organization were calculated and matched with the respective country data on household size, Gross Domestic Product (GDP), urban population and ageing. Scatter plots were produced to explore and visualize the correlations between household size and dementia mortality rates. Pearson’s and nonparametric correlations were used to evaluate the strength and direction of the associations between household size and all other variables. Partial correlation of Pearson’s approach was used to identify that household size protects against dementia regardless of the competing effects from ageing, GDP and urbanization. Multiple regression was used to identify significant predictors of dementia mortality. Results Household size was in a negative and moderately strong correlation (r = -0.6034, p < 0.001) with dementia mortality. This relationship was confirmed in both Pearson r (r = - 0.524, p<0.001) and nonparametric (rho = -0.579, p < 0.001) analyses. When we controlled for the contribution of ageing, socio-economic status and urban lifestyle in partial correlation analysis, large household was still in inverse and significant correlation to dementia mortality (r = −0.331, p <0.001). This suggested that, statistically, large household protect against dementia mortality regardless of the contributing effects of ageing, socio-economic status and urban lifestyle. Stepwise multiple regression analysis selected large household as the variable having the greatest contribution to dementia mortality with R2 = 0.263 while ageing was placed second increasing R2 to 0.259. GDP and urbanization were removed as having no statistically significant influence on dementia mortality. Conclusions While acknowledging ageing, urban lifestyle and greater GDP associated with dementia mortality, this study suggested that, at population level, household size was another risk factor for dementia mortality. As part of dementia prevention, healthcare practitioners should encourage people to increase their positive interactions with persons from their neighbourhood or other fields where large household/family size is hard to achieve.

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Section: Discussionmentioning

confidence: 99%

Large household reduces dementia mortality: A cross-sectional data analysis of 183 populations

You

Henneberg

2022

PLoS ONE

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“…In general medical practices, the suspicion index for dementia at a young age is low and such cases usually represent a diagnostic challenge given the low presence of key manifestations, unspecific symptoms and the younger age at presentation. Collectively, these factors can result in a delayed diagnosis relative to older dementia patients 3…”

Section: Discussionmentioning

confidence: 99%

Early-onset dementia: diagnostic challenges

2020

Self Cite

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A 56-year-old man was brought to our hospital by his family, seeking medical treatment for the patient’s long-standing progressive word-finding difficulties, forgetfulness, agitation and social withdrawal. After multiple previous physician consultations, the patient was mistakenly diagnosed with epilepsy and prescribed multiple anticonvulsants, to which his above mentioned symptoms were unresponsive. His condition progressed over the next 10 years, resulting in severe cognitive impairments and a complete dysfunctionality. An electroencephalogram (EEG) assessment revealed persistent spike and wave activity in the left temporal lobe. Brain MRI revealed multiple small bright T2 and fluid attenuated inversion recovery (FLAIR) foci within the white matter of both cerebral hemispheres surrounding the ventricular system, as well as some widening of extra-axial cerebrospinal fluid spaces. The patient was finally diagnosed with early-onset dementia and temporal lobe epileptiform abnormalities. This case emphasises the need for diagnostic consideration of dementia in cognitively impaired patients, even when they are not of an advanced age.

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“…Large household is even more important for pre-dementia patient, especially the young onset dementia. Generally, young onset dementia present non-specific signs and symptoms at the early onset in young patient, but they are progressing and irreversible [125]. With household residents' observations and encouragement, the atypical dementia symptoms can be noticed by coresidential members, and accordingly they can have the examination in time, and proper treatment subsequently.…”

Section: Social Support From Household Residents Promotes Healthy Lifestylementioning

confidence: 99%

Large household reduces dementia mortality

You¹

2022

Preprint

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Background Large households/families create more positive psychological well-being which may offer a life course protection against dementia development and deliver more comprehensive healthcare to dementia patients. Methods Dementia specific mortality rates of the 183 member states of World Health Organization were calculated and matched with the respective country data on household size, Gross Domestic Product (GDP), urban and ageing. Scatter plots were produced to explore and visualize the correlations between household size and dementia mortality rates. Pearsons and nonparametric correlations were used to evaluate the strength and direction of the associations between household size and all other variables. Partial correlation of Pearsons moment-product approach was used to identify that household size protects against dementia regardless of the competing effects from ageing, GDP and urbanization. Multiple regression identified large household was a significant predictor of dementia mortality. Results Household size was in a negative and moderately strong correlation (r = -0.6034, p < 0.001) with dementia mortality. This relationship was confirmed in both Pearson r (r= - 0.524, p<0.001) and nonparametric (rho = -0.579, p < 0.001) analyses. Regardless of the contribution of ageing, SES and urban lifestyle to dementia mortality, large household was an independent predictor of dementia mortality (r = −0.331, p <0.001) in partial correlation analysis. Stepwise multiple regression analysis selected large household as the variable having the greatest contribution to dementia mortality with R2 = 0.263 while ageing was placed second increasing R2 to 0.259. GDP and urbanization were removed as having no statistically significant influence on dementia mortality. Conclusions Independent of ageing, urbanization and GDP, large household protects against dementia mortality. As part of dementia prevention, healthcare practitioners should encourage people to increase their positive interactions with persons from their neighbourhood or other fields where large household/family size is hard to achieve.

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Atypical presentation of progressive young onset dementia

Cited by 3 publications

References 19 publications

Large household reduces dementia mortality: A cross-sectional data analysis of 183 populations

Large household reduces dementia mortality: A cross-sectional data analysis of 183 populations

Early-onset dementia: diagnostic challenges

Large household reduces dementia mortality

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