Atypical presentation of pigmented villonodular synovitis: A case report

AlDakhil, Mohammed A; AlDakhil, Abdulaziz M; Karami, Moyassar M; Satti, Mohamed B.

doi:10.4103/sjmms.sjmms_180_16

Cited by 2 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diagnosis of PVNS even on MRI is not straightforward as has been reported in the studies of Nair et al , Irisarri et al , Bhatnagar et al , Luo et al and Aldakhil et al 3 , 5 , 7 , 9 , 10 One of the common differential diagnoses that was offered in MRI in the aforesaid studies was of Giant Cell Tumor of the tendon sheath irrespective of the site of occurrence.…”

Section: Discussionmentioning

confidence: 98%

Case Report: Cytodiagnosis of pigmented villonodular synovitis involving carpal bones of right wrist

Giri Goswami,

Bhake,

Khan

et al. 2023

F1000Res

View full text Add to dashboard Cite

Background Pigmented Villonodular Synovitis (PVNS) is a rare disease of osteoskeletal tissue. Cytodiagnosis of PVNS on fine needle aspiration (FNA) smears is therefore rarely reported. The PVNS usually affects the larger joints. The involvement of the smaller joints and bones are uncommon. Case presentation The reported case is one such rarity wherein the diagnosis of PVNS was carried out on the FNAC. The case showed the involvement of all carpal bones except for the pisiform. The 2nd- 5th metacarpal bases were also found to be involved in the disease process. The presence of sheets of synoviocytes with brown altered hue to the cytoplasm along with multinucleate giant cells and pigmented macrophages were characteristically present in the smears of FNA. The diagnosis was confirmed on the tissue biopsy. The present case is reported for its unusual multiosteotic involvement of wrist joint bones and the metacarpal bones simultaneously with radiological evidence. The cytomorphology of the lesion in the present case were noteworthy as a learning experience in reporting of PVNS of wrist joint on FNA smears.

show abstract

Section: Discussionmentioning

confidence: 98%

Case Report: Cytodiagnosis of pigmented villonodular synovitis involving carpal bones of right wrist

Giri Goswami,

Bhake,

Khan

et al. 2023

F1000Res

View full text Add to dashboard Cite

show abstract

“…TGCT is challenging to diagnose due to the relatively non-specific signs or symptoms at presentation, which cover wide differential diagnoses [5,6]. Plain X-rays may be unremarkable, and MRI of the affected joint is the most sensitive imaging modality [7][8][9][10]. Histopathological analysis is necessary to confirm diagnosis, with microscopy often revealing mononuclear cells (including histiocytes), macrophages with extensive hemosiderin stores, and multinucleated osteoclast-type giant cells [11].…”

Section: Clinical Evaluationmentioning

confidence: 99%

Tenosynovial giant cell tumor: a case report

Ansel,

Yan,

Chong

et al. 2023

J Med Case Reports

View full text Add to dashboard Cite

Background This case reports the synchronous diagnosis of two rare unrelated diseases; leiomyosarcoma and tenosynovial giant cell tumor of the knee. It focuses on the challenges of diagnosing tenosynovial giant cell tumor, including cognitive biases in clinical medicine that delay diagnosis. It also demonstrates the pathogenic etiology of tenosynovial giant cell tumor, evidenced by the transient deterioration of the patients’ knee symptoms following the administration of prophylactic granulocyte colony-stimulating factor given as part of the chemotherapeutic regime for leiomyosarcoma. Case presentation A 37-year-old Caucasian man presented with a left groin lump and left knee pain with swelling and locking. Investigations including positron emission tomography-computed tomography and biopsy revealed leiomyosarcoma in a lymph node likely related to the spermatic cord, with high-grade uptake in the left knee that was presumed to be the primary site. His knee symptoms temporarily worsened each time granulocyte colony-stimulating factor was administered with each cycle of chemotherapy for leiomyosarcoma to help combat myelosuppressive toxicity. Subsequent magnetic resonance imaging and biopsy of the knee confirmed a tenosynovial giant cell tumor. His knee symptoms relating to the tenosynovial giant cell tumor improved following the completion of his leiomyosarcoma treatment. Conclusions Tenosynovial giant cell tumor remains a diagnostic challenge. We discuss the key clinical features and investigations that aid prompt diagnosis. The National Comprehensive Cancer Network clinical practice guidelines for soft tissue sarcoma have recently been updated to include the pharmacological management of tenosynovial giant cell tumor. Our case discussion provides an up-to-date review of the evidence for optimal management of patients with tenosynovial giant cell tumor, with a particular focus on novel pharmacological options that exploit underlying pathogenesis.

show abstract

Atypical presentation of pigmented villonodular synovitis: A case report

Cited by 2 publications

References 7 publications

Case Report: Cytodiagnosis of pigmented villonodular synovitis involving carpal bones of right wrist

Case Report: Cytodiagnosis of pigmented villonodular synovitis involving carpal bones of right wrist

Tenosynovial giant cell tumor: a case report

Contact Info

Product

Resources

About