Atypical Presentation of IgA Nephropathy Mimicking Acute Pyelonephritis

Abstract

Background IgA glomerulonephritis may present with hematuria, flank pain, and fever. This clinical presentation may be easily confused with acute pyelonephritis. Case Report We present the case of a 25-year-old female with a typical clinical presentation for acute pyelonephritis (high fever, left flank pain, left costovertebral angle tenderness, hematuria, elevated inflammatory markers, and a hypoenhancing region in the left kidney on contrast-enhanced computed tomography). However, urine and blood cultures were both negative, the serum creatinine was elevated, and the urinalysis revealed significant proteinuria and dysmorphic red blood cells. A kidney biopsy confirmed a diagnosis of IgA nephropathy. She was treated with a combination of lisinopril and methylprednisolone, with good response. Conclusion Gross hematuria, especially in the absence of pyuria or bacteriuria, should raise the suspicion for underlying IgA nephropathy, even if the rest of the clinical presentation is typical for a urinary tract infection. The presence of significant proteinuria, red blood cell casts, and dysmorphic red blood cells are useful clues suggesting glomerular disease.

Persistent hiccups as a rare presenting symptom of empyema: a case report

“…A total of 16 case reports involving patients with respiratory infections and hiccups were identified. Excluding 10 case reports related to coronavirus disease 2019 (COVID-19), the main findings of the remaining 6 case reports [ 4 – 9 ] with pneumonia or empyema were summarized in Table 1 . Most reported cases involved an infection in the right lower lobe.…”