Atypical presentation of entomophthoromycosis caused byConidiobolus coronatus

A Rhinofacial Conidiobolus coronatus Fungal Infection Presenting as an Intranasal Tumour

“…5,[9][10][11] Overall, very few cases of rhinofacial C. coronatus infections have been reported in the literature; as such, early identification of the organism remains challenging. 1,3,4 To the best of the authors' knowledge, the current case is the first report of a patient with rhinofacial conidiobolomycosis from the UAE. The diagnosis of a C. coronatus infection is based on a tissue biopsy in which eosinophilic deposits surrounding the hyphae can be seen (i.e.…”

“…1 The main symptoms of C. coronatus infections are facial deformation with extensive nasal blockage and bleeding due to the presence of subcutaneous granulomatous lesions. 1,3,4 The fungus usually infects healthy male farm workers between 20-60 years old. 1,2 In humans, C. coronatus infections likely occur due to inhalation of the fungal spores which imbed into the nasal mucosa; subsequently, as a result of enzymatic activity, they can penetrate into the subcutaneous area of the face as well as the nasal cavity and sinuses.…”

Subcutaneous entomophthoromycosis mimicking soft-tissue sarcoma in children

“…Further, the clinical features and treatment of both the fungal infections are mostly identical that their differentiation is academic rather than of clinical importance. For these reasons, we prefer -like many other authors [5,8,11] -the encompassing term 'entomophthoromycosis' despite its cumbersome spelling. Basidiobolus meristosporus and B.haptosporus, which were previously considered as different organisms, are now considered synonymous with B. ranarum [23].…”

“…EM is common in tropical areas such as sub-Saharan Africa [2], South East Asia [5], and Brazil [6]. However, probably due to international travels, it is increasingly been reported from nonendemic areas such as USA [7], Australia [8], Germany [9], Arabian peninsula [10], Portugal [11] and Netherlands [12].…”

Conidiobolomycosis in a Young Malaysian Woman Showing Chronic Localized Fibrosing Leukocytoclastic Vasculitis

“…Persistent inflammation is a known exacerbating factor of localized lymphedema complicated by elephantiasis. [12][13][14]22,26,32,33 Moreover, in vitro testing of Conidiobolus species isolates has also shown multidrug resistance. 2,33,63,64 Ostensibly, successful treatment of conidiobolomycosis has been reported for all forms of therapy used against this fungus: surgical excision of early inflammatory tumors 65 and antifungal Rx for more extensive disease (see Supplemental Digital Content Table 1, http://links.lww.com/AJDP/A5).…”