Atypical Presentation of an Atypical Carcinoid

Brandt, V. Van; Heyman, Stijn; Marck, Eric Van; Hendriks, Jeroen; Schil, Paul Van

doi:10.1016/j.athoracsur.2009.04.124

Cited by 8 publications

(6 citation statements)

References 13 publications

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“…It is known that a vast majority of carcinoids in the thymus would correspond to ACs if the same criteria are applied as the lung 6. In addition, several studies have reported that a substantial number of cases of AC are associated with ectopic hormone secretion 5,11,12. In the current study, our clinical series of patients (n=21) comprised 18 cases of AC and 3 cases of LCNEC.…”

Section: Discussionmentioning

confidence: 93%

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Clinicopathological Analysis of 21 Thymic Neuroendocrine Tumors

Ahn

Lee

et al. 2012

Korean J Pathol

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BackgroundThymic neuroendocrine carcinomas (NECs) are uncommon, for which there is no established information available because of a limited number of epidemiological study in Asia.MethodsWe reviewed 21 cases of surgically resected thymic NECs, and evaluated their pathological and clinical features.ResultsIt showed male predominance (male/female ratio, 15/6) with wide age range from 20 to 72 years (mean age, 49 years). All 21 cases were divided into two types according to the World Health Organization criteria: atypical carcinoid (n=18) and large cell NEC (n=3). Three cases of atypical carcinoid (AC) were associated with ectopic Cushing's syndrome. All the patients (3/3) with large cell NEC (3/3) and 16.7% (3/18) of those with AC died of tumor progression. Common sites of metastasis included lung, lymph node, brain, lumbar spine, mediastinum, bone, and liver.ConclusionsIn conclusion, thymic neuroendocrine tumors carry a poor prognosis. Regarding the tumor classification, our results showed that a vast majority of carcinoids in the thymus correspond to ACs. In addition, our results also indicate that typical carcinoid is a very rare entity. Some cases of AC exhibited a large size, solid pattern and they showed aggressive clinical behavior, which highlights the spectrum of histologic appearances of thymic NECs.

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Section: Discussionmentioning

confidence: 93%

“…To date, only a few studies have reported a substantial number of cases of NEC 1-5. The current evaluation of thymic neuroendocrine tumors is dependent on criteria for doing primary pulmonary neuroendocrine tumors 6.…”

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confidence: 99%

Clinicopathological Analysis of 21 Thymic Neuroendocrine Tumors

Ahn

Lee

et al. 2012

Korean J Pathol

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“…Even If the tumor is non-resectable, debulking is considered best. [4] Chemotherapy and radiotherapy may be considered either preoperatively or postoperatively, although because of small number of patients, standard guidelines about optimal treatment modalities have not been completely established. [3] Survival in an individual patient will depend upon stage at presentation, histologic degree of differentiation, associated endocrine features, and resectability rate.…”

Section: Discussionmentioning

confidence: 99%

Anterior mediastinal mass in a patient with Cushing′s syndrome

et al. 2012

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“…As mediastinal carcinoid tumours are rare neoplasms, we want to add an additional case we recently encountered (2). An atypical thymic carcinoid presented with massive mediastinal hemorrhage in a 83-year-old patient.…”

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confidence: 95%