Atypical prefrontal cortical responses to joint/non-joint attention in children with autism spectrum disorder (ASD): A functional near-infrared spectroscopy study

Zhu, Huilin; Li, Jun; Fan, Yuebo; Li, Xinge; Huang, Dan; He, Sailing

doi:10.1364/boe.6.000690

Cited by 31 publications

(25 citation statements)

References 33 publications

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“…The statistical hypothesis test was performed on the difference of the two groups, showing the differences in HbO 2 for 5 channel pairs were significant, i.e., p<0.05 after the false discovery rate (FDR) correction. These 5 channel pairs were (3,17), (11,24), (10,20), (8,22) and (9,21), with the corrected p value being 0.0069, 0.0111, 0.0117, 0.0137, and 0.0431, respectively. To investigate atypical features of the spontaneous fluctuations for ASD, the fluctuation power for HbO 2 and Hb were also calculated and compared for each group and shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Studies with various imaging modalities have already revealed significant functional or structural alterations associated with ASD in brain regions [4][5][6][7][8][9][10][11]32]. However, there is a vigorous debate on the clinical use of diagnostic imaging for ASD [27].…”

Section: Discussionmentioning

confidence: 99%

“…Diagnosis of ASD relies solely on behavioral observations, e.g., via the Autism Diagnostic Observation Schedule (ADOS), the gold standard standardized ASD diagnostic measure [2,3]. Several recent imaging studies [4][5][6][7][8][9][10][11] have noted significant alteration in brain organization or function associated with ASD that may open up an avenue for imaging-based diagnostic aides in ASD.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of autism spectrum disorder with spontaneous hemodynamic activity

Qiu

et al. 2016

Biomed. Opt. Express

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Functional near-infrared spectroscopy (fNIRS) was used to investigate spontaneous hemodynamic activity in the temporal cortex for typically developing (TD) children and children with autism spectrum disorder (ASD). Forty-seven children participated in the experiments including twenty-five with ASD. Compared with TD children, children with ASD showed weaker bilateral resting-state functional connectivity (RSFC), but much stronger fluctuation magnitude in terms of oxy-hemoglobin (HbO 2 ) and deoxy-hemoglobin (Hb). Differentiating between ASD and TD based on a support vector machine (SVM) model including bilateral RSFC and the fluctuation power of HbO 2 and Hb as variables could achieve high accurate classification with sensitivity of 81.6% and specificity of 94.6%. This study demonstrates optical brain imaging has the potential for screening children with risk of ASD.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization of autism spectrum disorder with spontaneous hemodynamic activity

Qiu

et al. 2016

Biomed. Opt. Express

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“…Most studies using optical methods to measure the hemodynamics of autism have used functional near‐infrared spectroscopy ( f NIRS), which can detect changes in hemoglobin concentration within the human brain based upon absorption coefficient calculations . More recently, the use of diffuse optical tomography (DOT) in autism spectrum disorder (ASD) was also demonstrated .…”

Section: Introductionmentioning

confidence: 99%

Optically derived metabolic and hemodynamic parameters predict hippocampal neurogenesis in the BTBR mouse model of autism

Abookasis

Lerman

Roth

et al. 2017

Journal of Biophotonics

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In this study, we made use of dual-wavelength laser speckle imaging (DW-LSI) to assess cerebral blood flow (CBF) in the BTBR-genetic mouse model of autism spectrum disorder, as well as control (C57Bl/6J) mice. Since the deficits in social behavior demonstrated by BTBR mice are attributed to changes in neural tissue structure and function, we postulated that these changes can be detected optically using DW-LSI. BTBR mice demonstrated reductions in both CBF and cerebral oxygen metabolism (CMRO ), as suggested by studies using conventional neuroimaging technologies to reflect impaired neuronal activation and cognitive function. To validate the monitoring of CBF by DW-LSI, measurements with laser Doppler flowmetry (LDF) were also performed which confirmed the lowered CBF in the autistic-like group. Furthermore, we found in vivo cortical CBF measurements to predict the rate of hippocampal neurogenesis, measured ex vivo by the number of neurons expressing doublecortin or the cellular proliferation marker Ki-67 in the dentate gyrus, with a strong positive correlation between CBF and neurogenesis markers (Pearson, r = 0.78; 0.9, respectively). These novel findings identifying cortical CBF as a predictive parameter of hippocampal neurogenesis highlight the power and flexibility of the DW-LSI and LDF setups for studying neurogenesis trends under normal and pathological conditions.

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“…fNIRS has excellent time resolution and acceptable spatial resolution [4]. Due to its non-invasiveness, low cost and portability [5], fNIRS has been increasingly applied to various areas, such as the detection of deception.…”

Section: Introductionmentioning

confidence: 99%

Using functional near-infrared spectroscopy (fNIRS) to detect the prefrontal cortical responses to deception under different motivations

Zhu

Gao

et al. 2015

Biomed. Opt. Express

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Abstract:In this study, functional near-infrared spectroscopy (fNIRS) was adopted to investigate the prefrontal cortical responses to deception under different motivations. By using a feigned memory impairment paradigm, 19 healthy adults were asked to deceive under the two different motivations: to obtain rewards and to avoid punishments. Results indicated that when deceiving for obtaining rewards, there was greater neural activation in the right inferior frontal gyrus (IFG) than the control condition. When deceiving for avoiding punishments, there was greater activation in the right inferior frontal gyrus (IFG) and the left middle frontal gyrus (MFG) than the control condition. In addition, deceiving for avoiding punishments led to greater neural activation in the left MFG than when deceiving for obtaining rewards. Furthermore, the results showed a moderate hit rate in detecting deception under either motivation. These results demonstrated that deception with different motivations led to distinct responses in the prefrontal cortex. fNIRS could provide a useful technique for the detection of deception with strategy of feigning memory impairment under different motivations.

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Atypical prefrontal cortical responses to joint/non-joint attention in children with autism spectrum disorder (ASD): A functional near-infrared spectroscopy study

Cited by 31 publications

References 33 publications

Characterization of autism spectrum disorder with spontaneous hemodynamic activity

Characterization of autism spectrum disorder with spontaneous hemodynamic activity

Optically derived metabolic and hemodynamic parameters predict hippocampal neurogenesis in the BTBR mouse model of autism

Using functional near-infrared spectroscopy (fNIRS) to detect the prefrontal cortical responses to deception under different motivations

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