Atypical polypoid adenomyomas of the endometrium

Mazur, Michael T.

doi:10.1097/00000478-198107000-00006

Cited by 162 publications

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“…50,[60][61][62] Most patients are premenopausal or perimenopausal (average age 40 years) and present with abnormal uterine bleeding, usually menorrhagia. Rare examples have been described in patients with Turners syndrome who have been prescribed unopposed oestrogens.…”

Section: Adenomyomasmentioning

confidence: 99%

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

McCluggage

2016

Modern Pathology

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The current 2014 World Health Organization (WHO) Classification of mixed epithelial and mesenchymal tumours of the uterus includes categories of carcinosarcoma, adenosarcoma, adenofibroma, adenomyoma and atypical polypoid adenomyoma, the last two lesions being composed of an admixture of benign epithelial and mesenchymal elements with a prominent smooth muscle component. In this review, each of these categories of uterine neoplasm is covered with an emphasis on practical tips for the surgical pathologist and new developments. In particular, helpful clues in the distinction between carcinosarcoma and dedifferentiated endometrial carcinoma will be discussed. In addition, salient features to help distinguish between adenofibroma, adenosarcoma, embryonal rhabdomyosarcoma and other mesenchymal neoplasms in the differential diagnosis will be outlined. Finally, a discussion of adenomyoma and its main differential diagnostic considerations will be covered.

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Section: Adenomyomasmentioning

confidence: 99%

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

McCluggage

2016

Modern Pathology

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“…The lesion is composed of atypical endometrial glands with or without squamous metaplasia and a cellular smooth muscle mesenchyme that should be differentiated from infiltrating endometrioid adenocarcinoma and carcinosarcoma. 6 Although most APAs appear to be benign, coexistent endometrial adenocarcinoma and the subsequent development of endometrial adenocarcinoma have been reported in some cases of APA of the endometrium. 4,7,8,10,11 Therefore, local excision accompanied by close follow-up should be mandatory as a treatment program.…”

Section: Background: In 1981 Mazur Reported the Histologic Charactermentioning

confidence: 99%

Cytologic Features of Atypical Polypoid Adenomyoma of the Endometrium

Kimura¹,

Okamoto²,

Yamamoto³

et al. 2003

Acta Cytologica

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“…Atypical Polypoid Adenomyomas (APA) is a kind of uterine benign lesion which was first designated by Mazur [1] 2) METHODS: The formalin-fixed, paraffin-embedded tissues were sectioned at 5 um thickness for standard immunohistochemical staining. Slides were de-waxed for 15 min (2 times) in xylene, 5 min in absolute ethanol, 2 min in 95% ethanol, 2 min in 80% ethanol, and 5 min in distilled water, and then rehydrated into distilled H 2 O 2 through graded ethanol.…”

Section: Introductionmentioning

confidence: 99%

Atypical Polypoid Adenomyomas of Uterus: A Clinicopathologic Study of 2 Cases

Chongqing¹

2018

JBM

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Atypical polypoid Adenomyomas (APA) is a rare benign tumour in uterine. It is would distinguished from well-differentiated endometrial adenocarcinoma because of his histological features. We report 2 cases of 31-year-old and 33-year-old patient whose symptom were abnormal uterine bleeding. The mass was pedunculated with a narrow pedicle connecting to the pedunculated with a narrow pedicle connecting to the cervical; the other was in the uterine prolapse without pedicle. The surgical procedure was polypectomy only in all two patients with hysteroscopy. The histopathology showed the lesions were composed of a proliferation of irregular atypical endometrial glands separated by varying amounts of cellular smooth-muscle stroma. No mitotic activity was observed in the epithelial or mesenchymal elements in APA. The treatment of APA should depend on the age and reproductive desire of patient.

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Atypical polypoid adenomyomas of the endometrium

Cited by 162 publications

References 0 publications

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

Cytologic Features of Atypical Polypoid Adenomyoma of the Endometrium

Atypical Polypoid Adenomyomas of Uterus: A Clinicopathologic Study of 2 Cases

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