Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic

Yin, Qiaoqiao; Li, Yuecui; Pan, Heng; Hui, Tian-Chen; Yu, Zhaonan; Wu, Haiyan; Zhang, Dehe; Zheng, Wei; Wang, Shouhao; Zhou, Zhewen; Xu, Chengan; Wu, Wenhao; Tong, Yongxi; Wang, Haoyi; Pan, Hongying

doi:10.1016/j.ijid.2022.07.027

Cited by 9 publications

(12 citation statements)

References 41 publications

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“…Our results illustrated that the incidence of abnormal liver function and liver injury in patients with Chlamydia psittaci pneumonia who were admitted to our center was high, namely, 84.8% of patients with Chlamydia psittaci pneumonia had higher levels of ALT, AST, ALP, GGT, and TB at initial diagnosis, among which an elevated AST level was the most common. Similar to previous results, an elevated AST level was more common than an elevated ALT level ( Su et al., 2021 ; Li et al., 2022 ; Yin et al., 2022 ). A retrospective study including 52 patients with Chlamydia psittaci pneumonia conducted by Li et al.…”

Section: Discussionsupporting

confidence: 91%

Clinical features and risk factors of liver injury in patients with Chlamydia psittaci pneumonia- a retrospective analysis

Guo,

Zhu,

Chen

2024

Front. Cell. Infect. Microbiol.

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BackgroundResearch into the effects of Chlamydia psittaci pneumonia on the liver has emerged in the last few years. However, no studies have systematically described liver injury in patients with psittacosis. We present the first report on the clinical features and risk factors of liver injury in patients with Chlamydia psittaci pneumonia.MethodsWe retrospectively collected the clinical parameters for 46 patients with Chlamydia psittaci pneumonia admitted to Jinhua Central Hospital from January 2019 to February 2023. We analyzed the liver function parameters and summarized the clinical characteristics and risk factors of liver injury.ResultsAmong the 46 patients, 39 (84.8%) had abnormal liver function, and 23 (50.0%) had liver injury. The ratio of patients with a history of alcohol consumption (39.1% vs. 4.3%, P =0.004) or severe pneumonia (56.5% vs. 26.1%, P =0.036) was higher in the liver injury group compared with the non-liver injury group. Laboratory tests showed higher lactate dehydrogenase (LDH) levels in the liver injury group (P <0.001). The optimal cut-off LDH level associated with liver injury was 473 IU/L as determined by ROC curve analysis. Furthermore, multivariate logistic regression analysis demonstrated that a history of alcohol consumption (odds ratio [OR] = 11.251; 95% confidence interval [CI] = 1.022 ~ 123.897, P =0.048) and an LDH level of ≥ 473IU/L (OR = 11.635, 95% CI = 1.832 ~ 73.869, P =0.009) were independent risk factors for liver injury.ConclusionsA history of alcohol consumption and an LDH level of over 473 IU/L are independent risk factors for Chlamydia psittaci pneumonia-related liver injury. It is recommended that particular attention be given to monitoring and evaluating liver function parameters when treating patients with Chlamydia psittaci pneumonia who have a high LDH level and history of alcohol consumption.

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Section: Discussionsupporting

confidence: 91%

Clinical features and risk factors of liver injury in patients with Chlamydia psittaci pneumonia- a retrospective analysis

Guo,

Zhu,

Chen

2024

Front. Cell. Infect. Microbiol.

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“…Yin et al reported 32 cases of human infection with C. psittaci in Zhejiang Province during 2020-2021; in all of these cases, individuals had a history of exposure to poultry or pigeons [25]. The present study detected C. psittaci in a local LWPM in Changsha, suggesting the need to develop preventive and control measures for human C. psittaci infection in the context of the increasing number of human C. psittaci infection cases.…”

Section: Discussionmentioning

confidence: 49%

“…Chlamydia psittaci infections in humans are well-documented [6][7][8][9][10][11][12][13][14][15]. Most reported human C. psittaci infection cases are attributed to close contact with poultry [16][17][18][19][20][21][22][23][24][25]. To date, the largest psittacosis outbreak was reported in the United States in August 2018, with 82 poultry processing plant workers diagnosed with C. psittaci infection [26].…”

Section: Introductionmentioning

confidence: 99%

Chlamydia psittaci detected at a live poultry wholesale market in central China

Zhang,

Fu,

Luo

et al. 2024

Preprint

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Background We investigated the presence of Chlamydia psittaci in poultry and the environment in live poultry wholesale markets in Changsha during 2021–2022 and conducted phylogenetic analysis to understand its distribution in this market. Methods In total, 483 samples were analyzed using real-time polymerase chain reaction and 17 C. psittaci-positive samples using high-throughput sequencing, BLAST similarity, and phylogenetic analysis. Results Twenty two out of 483 poultry and environmental samples were positive for C. psittaci (overall positivity rate: 4.55%) with no difference in positivity rates over 12 months. Chlamydia psittaci was detected at 11 sampling points (overall positivity rate: 27.5%), including chicken, duck, and pigeon/chicken/duck/goose shops, with pigeon shops having the highest positivity rate (46.67%). The highest positivity rates were found in sewage (12.5%), poultry fecal (7.43%), cage swab (6.59%), avian pharyngeal/anorectal swab (3.33%), and air (2.29%) samples. The ompA sequences were identified in two strains of C. psittaci, which were determined to bear genotype B using phylogenetic analysis. Thus, C. psittaci genotype B was detected in the poultry and environmental samples from the poultry wholesale market in Changsha during monitoring. Conclusions Monitoring programs for C. psittaci in live markets need to be strengthened to address the possible zoonotic threat.

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“…The most typical illness manifestation is an upper respiratory infection. It is assumed that about 1-8% of CAP is caused by psittacosis [101,103]. The laboratory diagnosis of psittacosis is usually difficult.…”

Section: Treatment Of Infections Due To C Psittacimentioning

confidence: 99%

Treatment of Chlamydial Infections

Cam¹

2023

Infectious Diseases

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Sexually transmitted infections (STIs) are a major health problem with an estimated burden of disease transmission as high as one million new cases per day globally. Chlamydia trachomatis, a member of the genus Chlamydia, is one of the most common and curable causative agents of STIs. C. trochomatis infections usually affect sexually active young adults and adolescents; and are composed of a broad spectrum of diseases varying from asymptomatic infection to severe genito-urinary infection leading to infertility and acute or chronic ocular infection (trachoma), which may result in blindness and pneumonia. Among the members of the genus Chlamydia, there are also two pathogenic species, Chlamydia pneumoniae and Chlamydia psittaci which are responsible for acute respiratory tract infections and febrile illness in humans. The incidence, pathophysiology, and diagnostic methods are discussed in detail in the previous chapters. The purpose of this chapter is to elucidate the management of infections due to C. trachomatis, C. pneumoniae, and C. psittaci including antibiotic susceptibility and resistance mechanisms, treatment recommendations for ocular infections, genito-urinary and respiratory tract infections, and management of sex partners, pregnant women, neonates, and children according to the latest data.

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Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic

Cited by 9 publications

References 41 publications

Clinical features and risk factors of liver injury in patients with Chlamydia psittaci pneumonia- a retrospective analysis

Clinical features and risk factors of liver injury in patients with Chlamydia psittaci pneumonia- a retrospective analysis

Chlamydia psittaci detected at a live poultry wholesale market in central China

Treatment of Chlamydial Infections

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