Atypical Pleomorphic Astrocytoma in the Pineal Gland: Case Report

Nitta, Junpei; Tada, Tsuyoshi; Kyoshima, Kazuhiko; Goto, Tetsuya; Hongo, Kazuhiro; Kobayashi, Shigeaki

doi:10.1097/00006123-200112000-00030

Cited by 27 publications

(34 citation statements)

References 8 publications

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“…3,9,10,14,15 In our case and in the case reported by Ohta et al, the tumor presented as a well-demarcated, low-intensity to isointense lesion in the pineal body and third ventricle wall with homogeneous contrast enhancement. 10 In these cases the CT and MRI characteristics were similar to the appearance of a large meningioma.…”

Section: 14supporting

confidence: 70%

“…The most frequent symptoms, including in our case, were dysfunctions of eye movements (Parinaud syndrome) and signs of rising intracranial tension caused by hydrocephalus (Table 1). Sudden-onset diplopia or visual loss, short-term history of confusion, headache, and vomiting have been described by Snipes et al 15 and Nitta et al 9 The duration of symptoms has ranged from sudden onset (5 days) to 4 years. Spontaneous intratumoral hemorrhage and intraventricular hemorrhage have also been reported in suprasellar region GCAs.…”

Section: Discussionmentioning

confidence: 94%

“…The pineal localization is extremely rare, with only 4 previously reported cases in the literature. 9,10,15 The histogenesis of a GCT is debated. For tumors that arise from the peripheral nervous system, Schwann cells appear to be the most likely cells of origin.…”

Section: Discussionmentioning

confidence: 99%

“…4,10,12,13 At the periphery of the tumor, gradual transition into classic astrocytoma is frequently found, although it can be subtle. [6][7][8][9]12 Tumors can be entirely composed of granular cells, but more often granular cells coexist with conventional infiltrating astrocytoma. Immunohistochemical studies show that most GCAs are positive for GFAP and S100.…”

Section: 14mentioning

confidence: 99%

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Diagnosis and management challenge of a granular cell astrocytoma of the pineal region: case report

Asri¹,

Baallal²,

Zoubeir

et al. 2015

PED

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Granular cell astrocytoma (GCA) is a rare type of infiltrative brain tumor with most reported cases occurring in the suprasellar region. A pineal localization is extremely rare, with only 4 previously reported cases in the literature. The authors describe the case of a 16-year-old boy who developed signs of increased intracranial pressure and Parinaud syndrome. Cranial CT and MRI revealed a well-demarcated and enhanced mass in the pineal region accompanied by obstructive hydrocephalus. Subtotal resection was performed via a subtemporal approach. A histological diagnosis of GCA was made. Three years after surgery, the patient was alive and well without adjuvant therapy, and serial MRI showed no signs of progression of a small residual tumor. After a thorough review of the different epidemiological, clinical, and imaging features; treatments; and prognoses of GCAs in other intracranial localizations, the authors analyzed features of this tumor in the pineal region.

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Section: 14supporting

confidence: 70%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: 14mentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis and management challenge of a granular cell astrocytoma of the pineal region: case report

Asri¹,

Baallal²,

Zoubeir

et al. 2015

PED

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“…Due to the lesion´s superficial location involving the cerebral cortex, seizures are the most common mode of presentation (3). Examples of this unusual neoplasm have also been reported in the cerebellum (11,12,14,23,31,35), pineal region (27), sella turcica (2), spinal cord (15,26), and even the retina (40). PXA often arises in adolescents and young adults and is amenable to surgical resection with good disease control (8), although it may harbor the potential for malignant transformation (1, 4, 5,6,9,25,28,30,32,38).…”

Section: Introductionmentioning

confidence: 99%

Intraventricular pleomorphic xanthoastrocytoma: a case report

Menéndez¹,

Fernández²,

MonTI³

et al. 2014

Turkish Neurosurgery

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Pleomorphic xanthoastrocytoma (PXA), an uncommon glial neoplasm, typically affects adolescents and young adults and accounts for less than 1% of all astrocytic neoplasms. The authors present a case of PXA located entirely in the third ventricle in a 24-year-old male patient. The patient presented with a 6-month history of headaches, progressive decline in cognitive function and profound behavioral disturbances. He was admitted to the hospital with signs of increased intracranial pressure. Magnetic resonance imaging showed a well-enhanced solid tumor, located entirely inside the third ventricle. The tumor was totally removed via a right fronto-pterional trans-lamina terminalis approach and neuropathology report confirmed PXA diagnosis. No further treatment was indicated. To the best of our knowledge, this is the first case report of a solid PXA confined to the third ventricle. KEywoRds: Pleomorphic xanthoastrocytoma, Intraventricular, Immuno-histochemical ÖZPleomorfik ksantoastrositom (PXA) nadir bir gliyal neoplazidir ve tipik olarak adolesanlar ve genç yetişkinlerde görülüp, tüm astrositik neoplazmların %1'inden azını oluşturur. Yazarlar 24 yaşında bir erkek hastada tamamen üçüncü ventrikülde bulunan PXA olgusu sunmaktadır. Hasta 6 aylık başağrısı, bilişsel işlevde giderek azalma ve belirgin davranış bozuklukları öyküsüyle geldi. Artmış intrakraniyal basınç bulgularıyla hastaneye yatırıldı. Manyetik rezonans görüntüleme tamamen üçüncü ventrikül içinde bulunan ve iyi kontrast tutan bir solid tümör gösterdi. Tümör sağ fronto-pterional trans-lamina terminalis yaklaşımı ile tamamen çıkarıldı ve nöropatoloji raporu PXA tanısını doğruladı. Başka bir tedavi gerekmedi. Bildiğimiz kadarıyla bu üçüncü ventrikülle sınırlı solid bir PXA için ilk olgu raporudur.

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Pleomorphic Xanthoastrocytoma

Farmer

Parolin

2010

Oncology of CNS Tumors

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Atypical Pleomorphic Astrocytoma in the Pineal Gland: Case Report

Cited by 27 publications

References 8 publications

Diagnosis and management challenge of a granular cell astrocytoma of the pineal region: case report

Diagnosis and management challenge of a granular cell astrocytoma of the pineal region: case report

Intraventricular pleomorphic xanthoastrocytoma: a case report

Pleomorphic Xanthoastrocytoma

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