Atypical pituitary hormone-target tissue axis

Xu, Chao; He, Zhao; Song, Yuelin; Shao, Shanshan; Yang, Guang; Zhao, Jiajun

doi:10.1007/s11684-022-0973-7

Cited by 1 publication

(3 citation statements)

References 134 publications

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“…In adipose tissue, ACTH stimulates lipolysis in mouse adipose tissue and adipocytes via MC2R-dependent cAMP/PKA activation. 21 The effects on hepatic lipid metabolism are more likely to be mediated through the HPA axis. Activation of the HPA axis pathway is closely related to insulin resistance (IR), glucose, and lipid metabolism disorders in type 2 diabetes mellitus (T2DM).…”

Section: Hpa Axis and Hepatic Lipid Homeostasismentioning

confidence: 99%

“…The concept of an “atypical pituitary hormone-target tissue axis” has been proposed because multiple types of pituitary hormone receptors are widely expressed in non-classical target organs, and each pituitary-derived hormone exhibits a wide range of biological effects in non-classical target organs. 21 Given the intricate metabolic pathways in the body, the role of endocrine hormones in different target organs deserves further exploration.…”

Section: Hpg Axis and Hepatic Lipid Homeostasismentioning

confidence: 99%

“…LHR gene expression levels in tissues are similar to those of FSHR. 21 The anterior pituitary gland releases the gonadotropins, FSH, and LH, to regulate gonadal function. The classical view is that the mechanism underlying dyslipidemia in menopausal women is estrogen deficiency.…”

Section: Fsh Lh and Hepatic Lipid Homeostasismentioning

confidence: 99%

See 2 more Smart Citations

Effects of the Pituitary-targeted Gland Axes on Hepatic Lipid Homeostasis in Endocrine-associated Fatty Liver Disease-A Concept Worth Revisiting

Li,

Zheng,

Limbara

et al. 2024

J Clin Transl Hepatol

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Hepatic lipid homeostasis is not only essential for maintaining normal cellular and systemic metabolic function but is also closely related to the steatosis of the liver. The controversy over the nomenclature of non-alcoholic fatty liver disease (NAFLD) in the past three years has once again sparked in-depth discussions on the pathogenesis of this disease and its impact on systemic metabolism. Pituitary-targeted gland axes (PTGA), an important hormone-regulating system, are indispensable in lipid homeostasis. This review focuses on the roles of thyroid hormones, adrenal hormones, sex hormones, and their receptors in hepatic lipid homeostasis, and summarizes recent research on pituitary target gland axes-related drugs regulating hepatic lipid metabolism. It also calls on researchers and clinicians to recognize the concept of endocrine-associated fatty liver disease (EAFLD) and to re-examine human lipid metabolism from the macroscopic perspective of homeostatic balance.

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Section: Hpa Axis and Hepatic Lipid Homeostasismentioning

confidence: 99%

Section: Hpg Axis and Hepatic Lipid Homeostasismentioning

confidence: 99%