Atypical neural synchronization to speech envelope modulations in dyslexia

Vos, Astrid De; Vanvooren, Sophie; Vanderauwera, Jolijn; Ghesquière, Pol; Wouters, Jan

doi:10.1016/j.bandl.2016.10.002

Cited by 50 publications

(54 citation statements)

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“…This higher neural synchronization to phoneme-rate modulations was correlated with poorer reading and phonological skills in that study. Similarly trending results were obtained for dyslexic adolescents (De Vos et al, 2017a). In that light, our findings support the 'oversampling' hypothesis brought forward by Lehongre and co-workers (2011).…”

Section: Isc Differences Between Dyslexics and Controlssupporting

confidence: 92%

“…According to this hypothesis, phoneme-rate information reflected in the beta band could be oversampled, resulting in working-memory overload and therefore slower or less accurate extraction of phonemic information from speech. Alternatively, enhanced synchronization in the beta band has been suggested to be a compensatory mechanism for the processing of phonemic-rate information (De Vos et al, 2017a). The maximal ISC difference in the largest cluster between the groups localized in the left middle temporal cortex.…”

Section: Isc Differences Between Dyslexics and Controlsmentioning

confidence: 99%

“…This question has previously been illuminated from different angles. For example, acoustic and rhythmic properties of the speech stimulus per se are reflected in oscillatory brain activity, which has been suggested to enhance speech perception and comprehension (Doelling et al, 2014;Luo and Poeppel, 2007;Obleser and Weisz, 2012;Peelle and Davis, 2012), differently so in dyslexics than typical readers (De Vos et al, 2017a;Power et al, 2016). The natural brain rhythms (i.e., oscillations) thereby seem to interplay with the speech stimulus that is being processed (for a review, see Meyer, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Atypical MEG inter-subject correlation during listening to continuous natural speech in dyslexia

Thiede

Glerean

Kujala

et al. 2019

Preprint

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AbstractListening to speech elicits brain activity time-locked to the speech sounds. This so-called neural entrainment to speech was found to be atypical in dyslexia, a reading impairment associated with neural speech processing deficits. We hypothesized that the brain responses of dyslexic vs. normal readers to real-life speech would be different, and thus the strength of inter-subject correlation (ISC) would differ from that of typical readers and be reflected in reading-related measures.We recorded magnetoencephalograms (MEG) of 23 dyslexic and 21 typically-reading adults during listening to ∼10 min of natural Finnish speech consisting of excerpts from radio news, a podcast, a self-recorded audiobook chapter and small talk. The amplitude envelopes of band-pass-filtered MEG source signals were correlated between subjects in a cortically-constrained source space in six frequency bands. The resulting ISCs of dyslexic and typical readers were compared with a permutation-based t-test. Neuropsychological measures of phonological processing, technical reading, and working memory were correlated with the ISCs utilizing the Mantel test.During listening to speech, ISCs were reduced in dyslexic compared to typical readers in delta (0.5–4 Hz), alpha (8–12 Hz), low gamma (25–45 Hz) and high gamma (55–90 Hz) frequency bands. In the beta (12–25 Hz) band, dyslexics had mainly enhanced ISC to speech compared to controls. Furthermore, we found that ISCs across both groups were associated with phonological processing, technical reading, and working memory.The atypical ISC to natural speech in dyslexics supports the temporal sampling deficit theory of dyslexia. It also suggests over-synchronization to phoneme-rate information in speech, which could indicate more effort-demanding sampling of phonemes from speech in dyslexia. These irregularities in parsing speech are likely some of the complex neural factors contributing to dyslexia. The associations between neural coupling and reading-related skills further support this notion.Research HighlightsMEG inter-subject correlation (ISC) of dyslexics was atypical while listening to speech.Depending on the frequency band, dyslexics had stronger or weaker ISC than controls.Reading-related measures correlated with the strength of ISC.

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Section: Isc Differences Between Dyslexics and Controlssupporting

confidence: 92%

Section: Isc Differences Between Dyslexics and Controlsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Atypical MEG inter-subject correlation during listening to continuous natural speech in dyslexia

Thiede

Glerean

Kujala

et al. 2019

Preprint

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“…All participants had normal hearing as their pure tone thresholds were better than 25 dB HL at all octave frequencies in both ears (125 Hz up to 8 kHz). During a short interview, the participant's medical history and education were questioned because it is known that serious concussions, medication for the treatment of insomnia (Van Lier et al, 2004) and learning disabilities such as dyslexia (Power et al, 2016;De Vos et al, 2017) can affect brain responses. The hand and ear preference of the participants were also determined using a Flemish, modified version of the laterality preference inventory of Coren (1993).…”

Section: Participantsmentioning

confidence: 99%

Top-down modulation of neural envelope tracking: the interplay with behavioral, self-report and neural measures of listening effort

Decruy

Lesenfants

Vanthornhout

et al. 2019

Preprint

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AbstractWhen listening to natural speech, our neural activity tracks the speech envelope. Moreover, recent research has demonstrated that this neural envelope tracking can be affected by top-down processes. The present study was designed to examine if neural envelope tracking is modulated by the effort that a person expends during listening. Five measures were included to quantify listening effort: two behavioral measures based on a novel dual-task paradigm, a self-report effort measure and two neural measures related to neural phase synchronization and alpha power. Electroencephalography responses to sentences, presented at a wide range of subject-specific signal-to-noise ratios, were recorded in thirteen young, normal-hearing adults. A comparison of the five measures revealed different effects of listening effort as a function of speech understanding. Reaction times on the primary task and self-reported effort decreased with increasing speech understanding. In contrast, reaction times on the secondary task and alpha power showed a peak-shaped behavior with highest effort at intermediate speech understanding levels. We found a positive association between envelope tracking and speech understanding. While a significant effect of listening effort was found on theta-band envelope tracking, the effect size was negligible. Therefore, our results suggest that listening effort is not a confound when using envelope tracking to objectively measure speech understanding in young, normal-hearing adults.

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“…Secondly, most functional neuroimaging studies of RD have employed fMRI or ERP techniques to investigate reading, auditory, or language processing at a relatively high level of analysis. As an important supplement, recent research has begun to improve our understanding of neural function at multiple, hierarchal timescales during language and sensory processing (Giraud & Poeppel, ), with evidence for anomalous neural oscillations and temporal processing at both slow (Cutini, Szucs, Mead, Huss, & Goswami, ; De Vos, Vanvooren, Vanderauwera, Ghesquiere, & Wouters, ; Goswami, ; Molinaro, Lizarazu, Lallier, Bourguignon, & Carreiras, ; Power, Colling, Mead, Barnes, & Goswami, ) and fast (Lehongre, Morillon, Giraud, & Ramus, ; Lehongre, Ramus, Villiermet, Schwartz, & Giraud, ) timescales in RD. Mechanistic models are available for linking these processes to neural coding (Hyafil, Fontolan, Kabdebon, Gutkin, & Giraud, ; Shamir, Ghitza, Epstein, & Kopell, ) and the role of excitatory‐inhibitory neural interactions in regulating these oscillations (Muthukumaraswamy, Edden, Jones, Swettenham, & Singh, ; Wang, ).…”

Section: Future Directionsmentioning

confidence: 99%

Neurobiological bases of reading disorder Part I: Etiological investigations

Xia

Hancock²,

Hoeft

2017

Language and Linguist. Compass

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While many studies have focused on identifying the neural and behavioral characteristics of decoding-based reading disorder (RD, aka developmental dyslexia), the etiology of RD remains largely unknown and understudied. Because the brain plays an intermediate role between genetic factors and behavioral outcomes, it is promising to address causality from a neural perspective. In the current, Part I of the two-part review, we discuss neuroimaging approaches to addressing the causality issue and review the results of studies that have employed these approaches. We assume that if a neural signature were associated with RD etiology, it would (a) manifest across comparisons in different languages, (b) be experience independent and appear in comparisons between RD and reading-matched controls, (c) be present both pre- and post-intervention, (d) be found in at-risk, pre-reading children and (e) be associated with genetic risk. We discuss each of these five characteristics in turn and summarize the studies that have examined each of them. The available literature provides evidence that anomalies in left temporo-parietal cortex, and possibly occipito-temporal cortex, may be closely related to the etiology of RD. Improved understanding of the etiology of RD can help improve the accuracy of early detection and enable targeted intervention of cognitive processes that are amenable to change, leading to improved outcomes in at-risk or affected populations.

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Atypical neural synchronization to speech envelope modulations in dyslexia

Cited by 50 publications

References 54 publications

Atypical MEG inter-subject correlation during listening to continuous natural speech in dyslexia

Atypical MEG inter-subject correlation during listening to continuous natural speech in dyslexia

Top-down modulation of neural envelope tracking: the interplay with behavioral, self-report and neural measures of listening effort

Neurobiological bases of reading disorder Part I: Etiological investigations

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